26 taxname
"Homo sapiens" ,
40 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
41 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
52 desc
"alpha-1-B glycoprotein" ,
65 locus
-tag
"HGNC:5" } ,
68 "alpha 1B-glycoprotein" ,
69 "alpha-1B-glycoprotein" } } ,
70 summary
"The protein encoded by this gene is a plasma glycoprotein of
71 unknown function. The protein shows sequence similarity to the variable
72 regions of some immunoglobulin supergene family member proteins." ,
75 display-str
"19q13.4" ,
89 accession
"NC_000019" ,
101 heading
"Reference" ,
102 accession
"NM_130786" ,
160 heading
"Reference" ,
161 accession
"NP_570602" ,
215 gi
21071030 } } } } } } ,
218 heading
"Reference" ,
219 accession
"NT_011109" ,
231 heading
"Reference" ,
232 accession
"NM_130786" ,
290 heading
"Reference" ,
291 accession
"NP_570602" ,
345 gi
21071030 } } } } } } ,
348 heading
"Reference" ,
349 accession
"NT_086907" ,
361 heading
"Reference" ,
362 accession
"NM_130786" ,
420 heading
"Reference" ,
421 accession
"NP_570602" ,
475 gi
21071030 } } } } } } } ,
479 label
"Nomenclature" ,
483 anchor
"HUGO Gene Nomenclature Committee" } } ,
487 label
"Official Symbol" ,
492 label
"Official Full Name" ,
493 text
"alpha-1-B glycoprotein" ,
497 heading
"GeneOntology" ,
501 pre
-text
"Provided by" ,
503 url
"http://www.ebi.ac.uk/GOA/" } } ,
521 anchor
"molecular_function unknown" ,
522 post
-text
"evidence: ND" } } } } } ,
537 anchor
"biological_process unknown" ,
538 post
-text
"evidence: ND" } } } } } ,
555 anchor
"extracellular region" ,
556 post
-text
"evidence: IDA" } } } } } } } } ,
560 heading
"Mouse, Rat" ,
568 anchor
"Map Viewer" ,
569 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=19&
570 MAPS=genes-r-org/rat-chr/human%3A19,genes-r-org/mouse-chr/human%3A19,genes-r-o
571 rg/human-chr19&query=e%3A1[id]+AND+gene[obj_type]&QSTR=a1bg&cmd=focus&fill=10" } } } } ,
575 heading
"LocusTagLink" ,
585 heading
"RefSeq Status" ,
602 heading
"Markers (Sequence Tagged Sites/STS)" ,
614 anchor
"SHGC-67307" ,
615 post
-text
"(e-PCR)" } } ,
619 label
"Alternate name" ,
624 label
"Alternate name" ,
637 post
-text
"(e-PCR)" } } ,
641 label
"Alternate name" ,
654 post
-text
"(e-PCR)" } } ,
658 label
"Alternate name" ,
663 label
"Alternate name" ,
665 version
0 } } } } } ,
668 heading
"NCBI Reference Sequences (RefSeq)" ,
673 heading
"mRNA Sequence" ,
674 accession
"NM_130786" ,
682 anchor
"NM_130786" } } ,
690 accession
"NP_570602" ,
699 post
-text
"alpha 1B-glycoprotein" } } ,
706 heading
"Consensus CDS (CCDS)" ,
713 str
"CCDS12976.1" } ,
714 anchor
"CCDS12976.1" } } } ,
717 heading
"Conserved Domains" ,
726 anchor
"summary" } } ,
737 anchor
"smart00408: IGc2; Immunoglobulin C-2 Type" } } ,
741 text
"Location: 223 - 282 Blast Score: 103" ,
742 version
0 } } } } } } } } ,
746 heading
"Source Sequence" ,
753 str
"AF414429,AK055885,AK056201" } ,
754 anchor
"AF414429,AK055885,AK056201" } } ,
758 version
0 } } } } } } } ,
761 heading
"Related Sequences" ,
767 accession
"AC010642" ,
775 anchor
"AC010642" } } ,
791 accession
"AB073611" ,
799 anchor
"AB073611" } } ,
806 accession
"BAD38648" ,
814 anchor
"BAD38648" } } ,
817 gi
51555785 } } } } ,
821 accession
"AF414429" ,
829 anchor
"AF414429" } } ,
836 accession
"AAL07469" ,
844 anchor
"AAL07469" } } ,
847 gi
15778556 } } } } ,
851 accession
"AK055885" ,
859 anchor
"AK055885" } } ,
871 accession
"AK056201" ,
879 anchor
"AK056201" } } ,
891 accession
"BC035719" ,
899 anchor
"BC035719" } } ,
906 accession
"AAH35719" ,
914 anchor
"AAH35719" } } ,
917 gi
23273476 } } } } ,
921 accession
"BX537419" ,
929 anchor
"BX537419" } } ,
936 accession
"CAD97661" ,
944 anchor
"CAD97661" } } ,
947 gi
31873340 } } } } ,
963 anchor
"P04217" } } ,
966 gi
46577680 } } } } } } ,
969 heading
"Additional Links" ,
978 db
"Evidence Viewer" ,
981 anchor
"Evidence Viewer" ,
982 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
983 g=NT_011109.15&gene=A1BG&lid=1&from=31124734&to=31133047" } } } ,
993 anchor
"ModelMaker" ,
994 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
995 06&contig=NT_011109.15&gene=A1BG&lid=1" } } } ,
1003 value
"Hs.529161" } } ,
1010 anchor
"Hs.529161" ,
1011 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=52
1023 anchor
"138670" } } } ,
1033 anchor
"HomoloGene" ,
1034 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
1035 1[loc]&TAXID=9606" } } } ,
1046 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
1047 ocusid&org=9606&l=1" } } } ,
1056 str
"GDB:119638" } } } } ,
1066 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=AK055
1077 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
1089 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC035719" } } } } } ,
1092 text
"A1BG-cysteine-rich secretory protein 3 complex displays a similar
1093 function in protecting the circulation from a potentially harmful effect of
1099 str
"Nov 6 2004 10:01AM" ,
1101 str
"Nov 6 2004 3:27PM" } } ,
1133 type protein
-coding
,
1138 taxname
"Homo sapiens" ,
1151 species
"sapiens" } ,
1152 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
1153 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
1160 subtype chromosome
,
1164 desc
"alpha-2-macroglobulin" ,
1165 maploc
"12p13.3-p12.3" ,
1175 locus
-tag
"HGNC:7" } ,
1178 "alpha-2-macroglobulin" } } ,
1179 summary
"Alpha-2-macroglobulin is a protease inhibitor and cytokine
1180 transporter. It inhibits many proteases, including trypsin, thrombin and
1181 collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability
1182 to mediate the clearance and degradation of A-beta, the major component of
1183 beta-amyloid deposits." ,
1186 display-str
"12p13.3-p12.3" ,
1193 gene
-display FALSE
,
1194 locus
-display FALSE
,
1195 extra
-terms FALSE
} ,
1199 heading
"Reference" ,
1200 accession
"NC_000012" ,
1212 heading
"Reference" ,
1213 accession
"NM_000014" ,
1439 heading
"Reference" ,
1441 accession
"NP_000005" ,
1663 gi
4557225 } } } } } } ,
1666 heading
"Reference" ,
1667 accession
"NT_009714" ,
1679 heading
"Reference" ,
1680 accession
"NM_000014" ,
1906 heading
"Reference" ,
1908 accession
"NP_000005" ,
2130 gi
4557225 } } } } } } ,
2133 heading
"Reference" ,
2134 accession
"NT_086792" ,
2146 heading
"Reference" ,
2147 accession
"NM_000014" ,
2373 heading
"Reference" ,
2375 accession
"NP_000005" ,
2597 gi
4557225 } } } } } } } ,
2601 label
"Nomenclature" ,
2605 anchor
"HUGO Gene Nomenclature Committee" } } ,
2609 label
"Official Symbol" ,
2614 label
"Official Full Name" ,
2615 text
"alpha-2-macroglobulin" ,
2619 heading
"GeneOntology" ,
2623 pre
-text
"Provided by" ,
2625 url
"http://www.ebi.ac.uk/GOA/" } } ,
2643 anchor
"enzyme binding" ,
2644 post
-text
"evidence: IPI" } } } ,
2656 anchor
"interleukin-1 binding" ,
2657 post
-text
"evidence: IDA" } } } ,
2669 anchor
"interleukin-8 binding" ,
2670 post
-text
"evidence: IPI" } } } ,
2680 anchor
"protein carrier activity" ,
2681 post
-text
"evidence: NR" } } } ,
2691 anchor
"serine-type endopeptidase inhibitor activity" ,
2692 post
-text
"evidence: IEA" } } } ,
2704 anchor
"tumor necrosis factor binding" ,
2705 post
-text
"evidence: IDA" } } } ,
2715 anchor
"wide-spectrum protease inhibitor activity" ,
2716 post
-text
"evidence: IEA" } } } } } ,
2731 anchor
"intracellular protein transport" ,
2732 post
-text
"evidence: NR" } } } ,
2742 anchor
"protein homooligomerization" ,
2743 post
-text
"evidence: NAS" } } } } } ,
2760 anchor
"extracellular region" ,
2761 post
-text
"evidence: NAS" } } } } } } } } ,
2765 heading
"Mouse, Rat" ,
2773 anchor
"Map Viewer" ,
2774 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=12&
2775 MAPS=genes-r-org/rat-chr/human%3A12,genes-r-org/mouse-chr/human%3A12,genes-r-o
2776 rg/human-chr12&query=e%3A2[id]+AND+gene[obj_type]&QSTR=a2m&cmd=focus&fill=10" } } } } ,
2780 heading
"LocusTagLink" ,
2790 heading
"RefSeq Status" ,
2854 heading
"Phenotypes" ,
2859 text
"Alzheimer disease, susceptibility to" ,
2867 anchor
"MIM: 103950" } } } ,
2870 text
"Emphysema due to alpha-2-macroglobulin deficiency" ,
2878 anchor
"MIM: 103950" } } } } } ,
2881 heading
"Markers (Sequence Tagged Sites/STS)" ,
2894 post
-text
"(e-PCR)" } } ,
2898 label
"Alternate name" ,
2903 label
"Alternate name" ,
2916 post
-text
"(e-PCR)" } } ,
2920 label
"Alternate name" ,
2925 label
"Alternate name" ,
2930 label
"Alternate name" ,
2943 post
-text
"(e-PCR)" } } ,
2947 label
"Alternate name" ,
2952 label
"Alternate name" ,
2965 post
-text
"(e-PCR)" } } ,
2969 label
"Alternate name" ,
2970 text
"WIAF-1430-STS" ,
2982 post
-text
"(e-PCR)" } } } ,
2993 post
-text
"(e-PCR)" } } } } } ,
2996 heading
"NCBI Reference Sequences (RefSeq)" ,
3001 heading
"mRNA Sequence" ,
3002 accession
"NM_000014" ,
3010 anchor
"NM_000014" } } ,
3018 accession
"NP_000005" ,
3026 anchor
"NP_000005" ,
3027 post
-text
"alpha-2-macroglobulin precursor" } } ,
3034 heading
"Conserved Domains" ,
3043 anchor
"summary" } } ,
3054 anchor
"pfam00207: A2M; Alpha-2-macroglobulin family" } } ,
3058 text
"Location: 725 - 1463 Blast Score: 2322" ,
3069 anchor
"pfam01835: A2M_N; Alpha-2-macroglobulin
3070 family N-terminal region" } } ,
3074 text
"Location: 21 - 628 Blast Score: 1948" ,
3075 version
0 } } } } } } } } ,
3079 heading
"Source Sequence" ,
3087 anchor
"M11313" } } ,
3091 version
0 } } } } } } } ,
3094 heading
"Related Sequences" ,
3100 accession
"AF349032" ,
3108 anchor
"AF349032" } } ,
3115 accession
"AAK38109" ,
3123 anchor
"AAK38109" } } ,
3126 gi
13661814 } } } } ,
3130 accession
"AF349033" ,
3138 anchor
"AF349033" } } ,
3145 accession
"AAK38110" ,
3153 anchor
"AAK38110" } } ,
3156 gi
13661816 } } } } ,
3160 accession
"X68728" ,
3168 anchor
"X68728" } } ,
3175 accession
"CAA48670" ,
3183 anchor
"CAA48670" } } ,
3190 accession
"Z11711" ,
3198 anchor
"Z11711" } } ,
3205 accession
"CAA77774" ,
3213 anchor
"CAA77774" } } ,
3220 accession
"AB209614" ,
3228 anchor
"AB209614" } } ,
3235 accession
"BAD92851" ,
3243 anchor
"BAD92851" } } ,
3246 gi
62088808 } } } } ,
3250 accession
"AF109189" ,
3258 anchor
"AF109189" } } ,
3265 accession
"AAQ13498" ,
3273 anchor
"AAQ13498" } } ,
3276 gi
33337724 } } } } ,
3280 accession
"AY591530" ,
3288 anchor
"AY591530" } } ,
3295 accession
"AAT02228" ,
3303 anchor
"AAT02228" } } ,
3306 gi
46812315 } } } } ,
3310 accession
"BC026246" ,
3318 anchor
"BC026246" } } ,
3325 accession
"AAH26246" ,
3333 anchor
"AAH26246" } } ,
3336 gi
45708661 } } } } ,
3340 accession
"BC040071" ,
3348 anchor
"BC040071" } } ,
3355 accession
"AAH40071" ,
3363 anchor
"AAH40071" } } ,
3366 gi
25303946 } } } } ,
3370 accession
"BX647329" ,
3378 anchor
"BX647329" } } ,
3390 accession
"CR749334" ,
3398 anchor
"CR749334" } } ,
3405 accession
"CAH18188" ,
3413 anchor
"CAH18188" } } ,
3416 gi
51476396 } } } } ,
3420 accession
"M11313" ,
3428 anchor
"M11313" } } ,
3435 accession
"AAA51551" ,
3443 anchor
"AAA51551" } } ,
3450 accession
"M36501" ,
3458 anchor
"M36501" } } ,
3465 accession
"AAA51552" ,
3473 anchor
"AAA51552" } } ,
3484 accession
"P01023" ,
3492 anchor
"P01023" } } ,
3495 gi
112911 } } } } } } ,
3498 heading
"Additional Links" ,
3507 db
"Evidence Viewer" ,
3510 anchor
"Evidence Viewer" ,
3511 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
3512 g=NT_009714.16&gene=A2M&lid=2&from=1979284&to=2027463" } } } ,
3522 anchor
"ModelMaker" ,
3523 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
3524 06&contig=NT_009714.16&gene=A2M&lid=2" } } } ,
3532 value
"Hs.212838" } } ,
3539 anchor
"Hs.212838" ,
3540 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=21
3552 anchor
"103950" } } } ,
3562 anchor
"HomoloGene" ,
3563 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
3564 2[loc]&TAXID=9606" } } } ,
3575 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
3576 ocusid&org=9606&l=2" } } } ,
3585 str
"GDB:119639" } } } } ,
3595 url
"http://www.uwcm.ac.uk/uwcm/mg/search/119639.html" } } } ,
3605 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=CR749
3616 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
3627 url
"http://www.genome.ad.jp/dbget-bin/www_bget?hsa:2" } } } ,
3638 anchor
"PA24357" } } } ,
3649 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC040071" } } } } } ,
3652 heading
"Pathways" ,
3657 text
"KEGG pathway: Alzheimer's disease" ,
3666 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa05010+2" } } } ,
3669 text
"KEGG pathway: Coagulation cascade" ,
3678 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
3681 text
"KEGG pathway: Complement and coagulation cascades" ,
3690 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
3693 text
"Reactome: Hemostasis" ,
3698 url
"http://www.reactome.org/cgi-bin/link?SOURCE=UniProt&ID=P010
3702 text
"an important involvement of alpha2M in regulation of increased
3703 proteolytic activity occurring in multiple sclerosis disease" ,
3708 str
"Dec 18 2004 10:01AM" ,
3710 str
"Dec 18 2004 1:19PM" } ,
3713 text
"alpha2-macroglobulin inhibits human pepsin and gastricsin" ,
3718 str
"Oct 7 2003 12:00AM" ,
3720 str
"Jul 7 2004 1:36PM" } ,
3723 text
"There is a significant genetic association of the 5 bp deletion
3724 and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin
3725 precursor with AD" ,
3730 str
"Jun 27 2004 5:41PM" ,
3732 str
"Jun 27 2004 6:18PM" } ,
3735 text
"Alpha2-macroglobulin is a substrate and an endogenous inhibitor
3736 for ADAMTS-4 and ADAMTS-5" ,
3741 str
"Jun 14 2004 4:41PM" ,
3743 str
"Jun 14 2004 5:44PM" } ,
3746 text
"A2M-D allele played a weak Alzheimer disease protective role, and
3747 APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk
3748 for mainland Han Chinese." ,
3753 str
"Feb 17 2004 12:00AM" ,
3755 str
"Apr 13 2004 1:35PM" } ,
3758 text
"Plasma from patients homozygous for the intronic deletion (DD)
3759 showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory
3760 activity. Plasma alpha(2)M from two DD patients showed markedly increased
3761 TGF-beta1 binding." ,
3766 str
"Jan 20 2004 12:00AM" ,
3768 str
"Mar 7 2004 7:01AM" } ,
3771 text
"The presence of MPO-G/G and A2M-Val/Val genotypes synergistically
3772 increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75)." ,
3777 str
"Mar 25 2004 12:00AM" ,
3779 str
"Apr 18 2004 7:02AM" } ,
3782 text
"alpha2-M deletion polymorphism is probably not associated with
3783 functional deficiencies important in Alzheimer's disease pathology" ,
3788 str
"Dec 31 2003 12:00AM" ,
3790 str
"Jan 11 2004 7:02AM" } ,
3793 text
"FGF-2 and this protein interact at specific binding sites,
3794 involving different FGF-2 sequences." ,
3799 str
"Sep 7 2003 12:00AM" ,
3801 str
"Sep 28 2003 7:01AM" } ,
3804 text
"alpha(2)M-derived peptides target the receptor-binding sequence in
3810 str
"Jun 25 2003 12:00AM" ,
3812 str
"Jul 6 2003 7:01AM" } ,
3815 text
"These results suggest the possible involvement of cathepsin E in
3816 disruption of the structural and functional integrity of alpha
3817 2-macroglobulin in the endolysosome system." ,
3822 str
"May 8 2003 12:00AM" ,
3824 str
"May 11 2003 7:01AM" } ,
3827 text
"Alpha 2-macroglobulin enhances prothrombin activation and thrombin
3828 potential by inhibiting the anticoagulant protein C/protein S system in cord
3829 and adult plasma." ,
3834 str
"Feb 6 2003 12:00AM" ,
3836 str
"Aug 17 2003 7:01AM" } ,
3839 text
"relationship between serum VEGF levels, alpha(2)M levels and the
3840 development of OHSS in hyperstimulated subjects undergoing IVF" ,
3845 str
"Dec 16 2002 12:00AM" ,
3847 str
"Feb 2 2003 7:00AM" } ,
3850 text
"Genetic association of alpha2-macroglobulin polymorphisms with
3851 Alzheimer's disease" ,
3856 str
"Sep 27 2002 12:00AM" ,
3858 str
"Oct 7 2002 8:10AM" } ,
3861 text
"Genetic association of argyrophilic grain disease with
3862 polymorphisms in alpha-2 macroglobulin." ,
3867 str
"Sep 24 2002 12:00AM" ,
3869 str
"Oct 7 2002 8:10AM" } ,
3872 text
"The three-dimensional structure of the dimer reveals its
3873 structural organization in the tetrameric native and chymotrypsin alpha
3874 2-macroglobulin complexes." ,
3879 str
"Sep 5 2002 12:00AM" ,
3881 str
"Sep 23 2002 6:27AM" } ,
3884 text
"has an important role in the AD-specific neurodegenerative process
3885 but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with
3886 late-onset sporadic AD in the Hungarian population" ,
3891 str
"Aug 6 2002 12:00AM" ,
3893 str
"Aug 28 2002 6:15PM" } ,
3896 text
"REVIEW: binds and neutralizes alfimeprase, which has direct
3897 proteolytic activity against the fibrinogen Aalpha chain" ,
3902 str
"Jun 12 2002 12:00AM" ,
3904 str
"Sep 7 2003 7:01AM" } ,
3907 text
"distinct binding sites mediate interaction with beta-amyloid
3908 peptide and growth factors" ,
3913 str
"May 4 2002 12:00AM" ,
3915 str
"May 18 2002 6:08AM" } ,
3918 text
"Differential binding to ldl receptor related protein" ,
3923 str
"Feb 14 2002 12:00AM" ,
3925 str
"Mar 4 2002 7:46AM" } ,
3928 heading
"HIV-1 protein interactions" ,
3933 text
"Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake
3934 and degradation of physiological ligands for LRP, including
3935 alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid
3944 accession
"NP_057853" ,
3954 accession
"NP_000005" ,
3957 str
"May 11 2004 12:48PM" ,
3959 str
"May 11 2004 1:10PM" } } } } ,
3974 value
"phenotype" } } }
4000 taxname
"Homo sapiens" ,
4013 species
"sapiens" } ,
4014 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4015 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4022 subtype chromosome
,
4026 desc
"alpha-2-macroglobulin pseudogene" ,
4027 maploc
"12p13.3-p12.3" ,
4028 locus
-tag
"HGNC:8" } ,
4031 display-str
"12p13.3-p12.3" ,
4038 gene
-display FALSE
,
4039 locus
-display FALSE
,
4040 extra
-terms FALSE
} ,
4044 heading
"Reference" ,
4045 accession
"NC_000012" ,
4060 heading
"Reference" ,
4061 accession
"NT_009714" ,
4076 heading
"Reference" ,
4077 accession
"NT_086792" ,
4092 heading
"Reference" ,
4093 accession
"NG_001067" ,
4109 label
"Nomenclature" ,
4113 anchor
"HUGO Gene Nomenclature Committee" } } ,
4117 label
"Official Symbol" ,
4122 label
"Official Full Name" ,
4123 text
"alpha-2-macroglobulin pseudogene" ,
4128 heading
"LocusTagLink" ,
4138 heading
"RefSeq Status" ,
4139 label
"PROVISIONAL" ,
4148 heading
"NCBI Reference Sequences (RefSeq)" ,
4153 heading
"Reference" ,
4154 accession
"NG_001067" ,
4162 anchor
"NG_001067" } } ,
4169 gi
20270626 } } } } } ,
4172 heading
"Related Sequences" ,
4178 accession
"M24415" ,
4186 anchor
"M24415" } } ,
4198 version
0 } } } } } ,
4201 heading
"Additional Links" ,
4210 db
"Evidence Viewer" ,
4213 anchor
"Evidence Viewer" ,
4214 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
4215 g=NT_009714.16&gene=A2MP&lid=3&from=2143176&to=2145882" } } } ,
4225 anchor
"ModelMaker" ,
4226 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
4227 06&contig=NT_009714.16&gene=A2MP&lid=3" } } } ,
4238 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
4239 ocusid&org=9606&l=3" } } } ,
4248 str
"GDB:128103" } } } } } } } ,
4259 status discontinued
,
4276 type protein
-coding
,
4281 taxname
"Homo sapiens" ,
4294 species
"sapiens" } ,
4295 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4296 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4303 subtype chromosome
,
4306 desc
"adenovirus-12 chromosome modification site 1C" ,
4312 "adenovirus-12 chromosome modification site 1C" ,
4313 "Adenovirus-12 chromosome modification site-1q1" } } ,
4316 display-str
"1q42-q43" ,
4323 gene
-display FALSE
,
4324 locus
-display FALSE
,
4325 extra
-terms FALSE
} ,
4333 heading
"RefSeq Status" ,
4338 heading
"Additional Links" ,
4349 str
"GDB:118950" } } } } } } } ,
4360 status discontinued
,
4377 type protein
-coding
,
4382 taxname
"Homo sapiens" ,
4395 species
"sapiens" } ,
4396 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4397 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4404 subtype chromosome
,
4407 desc
"adenovirus-12 chromosome modification site 1A" ,
4413 "adenovirus-12 chromosome modification site 1A" ,
4414 "Adenovirus-12 chromosome modification site-1p" } } ,
4417 display-str
"1p36" ,
4424 gene
-display FALSE
,
4425 locus
-display FALSE
,
4426 extra
-terms FALSE
} ,
4434 heading
"RefSeq Status" ,
4439 heading
"Additional Links" ,
4450 str
"GDB:118951" } } } } } } } ,
4461 status discontinued
,
4478 type protein
-coding
,
4483 taxname
"Homo sapiens" ,
4496 species
"sapiens" } ,
4497 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4498 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4505 subtype chromosome
,
4508 desc
"adenovirus-12 chromosome modification site 1B" ,
4514 "adenovirus-12 chromosome modification site 1B" ,
4515 "Adenovirus-12 chromosome modification site-1q2" } } ,
4518 display-str
"1q21" ,
4525 gene
-display FALSE
,
4526 locus
-display FALSE
,
4527 extra
-terms FALSE
} ,
4535 heading
"RefSeq Status" ,
4540 heading
"Additional Links" ,
4551 str
"GDB:118952" } } } } } } } ,
4562 status discontinued
,
4579 type protein
-coding
,
4584 taxname
"Homo sapiens" ,
4597 species
"sapiens" } ,
4598 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4599 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4606 subtype chromosome
,
4609 desc
"adenovirus-12 chromosome modification site 17" ,
4610 maploc
"17q21-q22" ,
4615 "adenovirus-12 chromosome modification site 17" } } ,
4618 display-str
"17q21-q22" ,
4625 gene
-display FALSE
,
4626 locus
-display FALSE
,
4627 extra
-terms FALSE
} ,
4635 heading
"RefSeq Status" ,
4640 heading
"Additional Links" ,
4651 str
"GDB:118953" } } } } } } } ,
4684 taxname
"Homo sapiens" ,
4697 species
"sapiens" } ,
4698 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
4699 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
4706 subtype chromosome
,
4710 desc
"atrophia areata, peripapillary chorioretinal degeneration" ,
4717 locus
-tag
"HGNC:11" } ,
4720 display-str
"11p15" ,
4727 gene
-display FALSE
,
4728 locus
-display FALSE
,
4729 extra
-terms FALSE
} ,
4737 label
"Nomenclature" ,
4741 anchor
"HUGO Gene Nomenclature Committee" } } ,
4745 label
"Official Symbol" ,
4750 label
"Official Full Name" ,
4751 text
"atrophia areata, peripapillary chorioretinal degeneration" ,
4756 text
"phenotype only" ,
4761 heading
"LocusTagLink" ,
4776 heading
"Phenotypes" ,
4781 text
"Atrophia areata" ,
4789 anchor
"MIM: 108985" } } } ,
4793 text
"atrophia areata, peripapillary chorioretinal degeneration" ,
4801 anchor
"HGNC:11" } } } } } ,
4804 heading
"Markers (Sequence Tagged Sites/STS)" ,
4817 post
-text
"(e-PCR)" } } ,
4821 label
"Alternate name" ,
4826 label
"Alternate name" ,
4831 label
"Alternate name" ,
4836 label
"Alternate name" ,
4841 label
"Alternate name" ,
4846 label
"Alternate name" ,
4851 label
"Alternate name" ,
4863 anchor
"D11S902 (flanking)" } } ,
4867 label
"Alternate name" ,
4872 label
"Alternate name" ,
4877 label
"Alternate name" ,
4882 label
"Alternate name" ,
4887 label
"Alternate name" ,
4892 label
"Alternate name" ,
4897 label
"Alternate name" ,
4910 post
-text
"(e-PCR)" } } ,
4914 label
"Alternate name" ,
4919 label
"Alternate name" ,
4924 label
"Alternate name" ,
4929 label
"Alternate name" ,
4941 anchor
"D11S1323 (flanking)" } } ,
4945 label
"Alternate name" ,
4950 label
"Alternate name" ,
4955 label
"Alternate name" ,
4960 label
"Alternate name" ,
4962 version
0 } } } } } ,
4965 heading
"Additional Links" ,
4978 anchor
"108985" } } } ,
4987 str
"GDB:568984" } } } } } } } ,
5002 value
"phenotype" } ,
5005 value
"phenotype only" } } }
5026 type protein
-coding
,
5031 taxname
"Homo sapiens" ,
5044 species
"sapiens" } ,
5045 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
5046 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
5053 subtype chromosome
,
5057 desc
"N-acetyltransferase 1 (arylamine N-acetyltransferase)" ,
5058 maploc
"8p23.1-p21.3" ,
5066 locus
-tag
"HGNC:7645" } ,
5069 "N-acetyltransferase 1" ,
5070 "arylamine N-acetyltransferase 1" ,
5071 "arylamide acetylase 1 (N-acetyltransferase 1)" } } ,
5074 display-str
"8p23.1-p21.3" ,
5081 gene
-display FALSE
,
5082 locus
-display FALSE
,
5083 extra
-terms FALSE
} ,
5087 heading
"Reference" ,
5088 accession
"NC_000008" ,
5100 heading
"Reference" ,
5101 accession
"NM_000662" ,
5129 heading
"Reference" ,
5130 accession
"NP_000653" ,
5151 value
"2.3.1.5" } } } } } } } } } ,
5154 heading
"Reference" ,
5155 accession
"NT_030737" ,
5167 heading
"Reference" ,
5168 accession
"NM_000662" ,
5196 heading
"Reference" ,
5197 accession
"NP_000653" ,
5218 value
"2.3.1.5" } } } } } } } } } ,
5221 heading
"Reference" ,
5222 accession
"NT_086740" ,
5234 heading
"Reference" ,
5235 accession
"NM_000662" ,
5263 heading
"Reference" ,
5264 accession
"NP_000653" ,
5285 value
"2.3.1.5" } } } } } } } } } } ,
5289 label
"Nomenclature" ,
5293 anchor
"HUGO Gene Nomenclature Committee" } } ,
5297 label
"Official Symbol" ,
5302 label
"Official Full Name" ,
5303 text
"N-acetyltransferase 1 (arylamine N-acetyltransferase)" ,
5307 heading
"GeneOntology" ,
5311 pre
-text
"Provided by" ,
5313 url
"http://www.ebi.ac.uk/GOA/" } } ,
5329 anchor
"acetyltransferase activity" ,
5330 post
-text
"evidence: IEA" } } } ,
5342 anchor
"arylamine N-acetyltransferase activity" ,
5343 post
-text
"evidence: TAS" } } } ,
5353 anchor
"transferase activity" ,
5354 post
-text
"evidence: IEA" } } } } } ,
5369 anchor
"metabolism" ,
5370 post
-text
"evidence: IEA" } } } } } } } } ,
5374 heading
"Mouse, Rat" ,
5382 anchor
"Map Viewer" ,
5383 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=8&M
5384 APS=genes-r-org/rat-chr/human%3A8,genes-r-org/mouse-chr/human%3A8,genes-r-org/
5385 human-chr8&query=e%3A9[id]+AND+gene[obj_type]&QSTR=nat1&cmd=focus&fill=10" } } } } ,
5389 heading
"LocusTagLink" ,
5399 heading
"RefSeq Status" ,
5440 heading
"Markers (Sequence Tagged Sites/STS)" ,
5452 anchor
"STS-R79401" ,
5453 post
-text
"(e-PCR)" } } ,
5457 label
"Alternate name" ,
5462 label
"Alternate name" ,
5474 anchor
"STS-D90041" ,
5475 post
-text
"(e-PCR)" } } ,
5479 label
"Alternate name" ,
5484 label
"Alternate name" ,
5497 post
-text
"(e-PCR)" } } ,
5501 label
"Alternate name" ,
5513 anchor
"PMC165273P2" ,
5514 post
-text
"(e-PCR)" } } } } } ,
5517 heading
"NCBI Reference Sequences (RefSeq)" ,
5522 heading
"mRNA Sequence" ,
5523 accession
"NM_000662" ,
5531 anchor
"NM_000662" } } ,
5539 accession
"NP_000653" ,
5547 anchor
"NP_000653" ,
5548 post
-text
"N-acetyltransferase 1" } } ,
5555 heading
"Consensus CDS (CCDS)" ,
5562 str
"CCDS6007.1" } ,
5563 anchor
"CCDS6007.1" } } } ,
5566 heading
"Conserved Domains" ,
5575 anchor
"summary" } } ,
5586 anchor
"pfam00797: Acetyltransf_2;
5587 N-acetyltransferase" } } ,
5591 text
"Location: 20 - 280 Blast Score: 1195" ,
5592 version
0 } } } } } } } } ,
5596 heading
"Source Sequence" ,
5603 str
"AV754344,BC047666,BQ024509" } ,
5604 anchor
"AV754344,BC047666,BQ024509" } } ,
5608 version
0 } } } } } } } ,
5611 heading
"Related Sequences" ,
5617 accession
"AF008204" ,
5625 anchor
"AF008204" } } ,
5632 accession
"AAB84384" ,
5640 anchor
"AAB84384" } } ,
5643 gi
2258431 } } } } ,
5647 accession
"AF032677" ,
5655 anchor
"AF032677" } } ,
5662 accession
"AAB86878" ,
5670 anchor
"AAB86878" } } ,
5673 gi
2641553 } } } } ,
5677 accession
"AF032678" ,
5685 anchor
"AF032678" } } ,
5692 accession
"AAB86879" ,
5700 anchor
"AAB86879" } } ,
5703 gi
2641555 } } } } ,
5707 accession
"AF067408" ,
5715 anchor
"AF067408" } } ,
5722 accession
"AAC24707" ,
5730 anchor
"AAC24707" } } ,
5733 gi
3265062 } } } } ,
5737 accession
"AF071552" ,
5745 anchor
"AF071552" } } ,
5752 accession
"AAC24712" ,
5760 anchor
"AAC24712" } } ,
5763 gi
3265152 } } } } ,
5767 accession
"AF082903" ,
5775 anchor
"AF082903" } } ,
5782 accession
"AAD13343" ,
5790 anchor
"AAD13343" } } ,
5793 gi
3435298 } } } } ,
5797 accession
"AF082904" ,
5805 anchor
"AF082904" } } ,
5812 accession
"AAC32388" ,
5820 anchor
"AAC32388" } } ,
5823 gi
3435300 } } } } ,
5827 accession
"AF308866" ,
5835 anchor
"AF308866" } } ,
5842 accession
"AAG23842" ,
5850 anchor
"AAG23842" } } ,
5853 gi
10834833 } } } } ,
5857 accession
"AJ278017" ,
5865 anchor
"AJ278017" } } ,
5872 accession
"CAC01128" ,
5880 anchor
"CAC01128" } } ,
5883 gi
9663145 } } } } ,
5887 accession
"AJ307007" ,
5895 anchor
"AJ307007" } } ,
5902 accession
"CAC38345" ,
5910 anchor
"CAC38345" } } ,
5913 gi
14018356 } } } } ,
5917 accession
"AY338489" ,
5925 anchor
"AY338489" } } ,
5932 accession
"AAP88036" ,
5940 anchor
"AAP88036" } } ,
5943 gi
32815076 } } } } ,
5947 accession
"AY376850" ,
5955 anchor
"AY376850" } } ,
5962 accession
"AAQ74989" ,
5970 anchor
"AAQ74989" } } ,
5973 gi
34555773 } } } } ,
5977 accession
"U80835" ,
5985 anchor
"U80835" } } ,
5992 accession
"AAB62398" ,
6000 anchor
"AAB62398" } } ,
6003 gi
2245376 } } } } ,
6007 accession
"X17059" ,
6015 anchor
"X17059" } } ,
6022 accession
"CAA34905" ,
6030 anchor
"CAA34905" } } ,
6037 accession
"AV754344" ,
6045 anchor
"AV754344" } } ,
6057 accession
"BC013732" ,
6065 anchor
"BC013732" } } ,
6077 accession
"BC047666" ,
6085 anchor
"BC047666" } } ,
6092 accession
"AAH47666" ,
6100 anchor
"AAH47666" } } ,
6103 gi
28838336 } } } } ,
6107 accession
"BQ024509" ,
6115 anchor
"BQ024509" } } ,
6127 accession
"BX647521" ,
6135 anchor
"BX647521" } } ,
6147 accession
"D90041" ,
6155 anchor
"D90041" } } ,
6162 accession
"BAA14095" ,
6170 anchor
"BAA14095" } } ,
6181 accession
"P18440" ,
6189 anchor
"P18440" } } ,
6192 gi
114234 } } } } } } ,
6195 heading
"Additional Links" ,
6204 db
"Evidence Viewer" ,
6207 anchor
"Evidence Viewer" ,
6208 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
6209 g=NT_030737.9&gene=NAT1&lid=9&from=5912543&to=5925748" } } } ,
6219 anchor
"ModelMaker" ,
6220 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
6221 06&contig=NT_030737.9&gene=NAT1&lid=9" } } } ,
6229 value
"Hs.155956" } } ,
6236 anchor
"Hs.155956" ,
6237 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=15
6249 anchor
"108345" } } } ,
6259 anchor
"HomoloGene" ,
6260 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
6261 9[loc]&TAXID=9606" } } } ,
6272 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
6273 ocusid&org=9606&l=9" } } } ,
6282 str
"GDB:125364" } } } } ,
6292 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=BC013
6303 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
6315 anchor
"PA17" } } } ,
6318 text
"Arylamine N-Acetyltransferase Nomenclature" ,
6323 db
"Arylamine N-Acetyltransferase Nomenclature" ,
6325 str
"Arylamine N-Acetyltransferase Nomenclature" } ,
6326 anchor
"Arylamine N-Acetyltransferase Nomenclature" ,
6327 url
"http://www.louisville.edu/medschool/pharmacology/NAT.html" } } } ,
6338 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC047666" } } } } } ,
6341 text
"In breast, NAT1 mRNA is transcribed from a strong promoter located
6342 11.8 kb upstream of the translated exon, and the mature spliced mRNA includes
6343 at least one additional non-coding exon." ,
6348 str
"Mar 26 2005 10:01AM" ,
6350 str
"Mar 26 2005 1:53PM" } ,
6353 text
"Polymorphism at the NAT1 locus has been associated with the
6354 existence of at least 26 allelic variants, generating phenotypic variations
6355 in terms NAT-1 catalytic activity. This genetic variation affects the
6356 acetylator status of individuals." ,
6361 str
"Dec 18 2004 10:01AM" ,
6363 str
"Mar 17 2005 6:52AM" } ,
6366 text
"NAT1 exists in the cell in either a stable acetylated state or an
6367 unstable non-acetylated state and mutations in the NAT1 gene that prevent
6368 protein acetylation produce a slow acetylator phenotype" ,
6373 str
"Jul 6 2004 11:50AM" ,
6375 str
"Jul 6 2004 12:11PM" } ,
6378 text
"Analysis of the effect of active NAT-1 overexpression in a normal
6379 luminal epithelial-derived cell line demonstrated enhanced growth properties
6380 and etoposide resistance relative to control cells." ,
6385 str
"Jun 23 2004 4:43PM" ,
6387 str
"Jun 23 2004 5:16PM" } ,
6390 text
"cellular generation of peroxynitrite may contribute to
6391 carcinogenesis and tumor progression by weakening key cellular defense
6392 enzymes such as arylamine N-acetyltransferase 1 (NAT1)" ,
6397 str
"Mar 24 2004 12:00AM" ,
6399 str
"May 9 2004 7:01AM" } ,
6402 text
"although there is little overall association between NAT genotypes
6403 and risk of developing systemic lupus erythematosus, the interaction between
6404 NAT1 and NAT2 and specific exposures such as hair dyes may be important." ,
6409 str
"Apr 16 2004 12:00AM" ,
6411 str
"May 2 2004 7:01AM" } ,
6414 text
"A putative RUNX1 binding site variant of NAT9 is associated with
6415 susceptibility to psoriasis" ,
6420 str
"Dec 18 2003 12:00AM" ,
6422 str
"Jan 11 2004 7:03AM" } ,
6425 text
"Identification of minimal promoter sequences for transcription
6426 factor binding sites in the human N-acetyltransferase Type I gene. that binds" ,
6431 str
"Nov 24 2003 12:00AM" ,
6433 str
"Dec 7 2003 7:02AM" } ,
6436 text
"Oxidative stress and cellular redox status may regulate NAT1
6437 activity and have important consequences with regard to drug
6438 biotransformation and cancer risk." ,
6443 str
"Oct 7 2003 12:00AM" ,
6445 str
"Nov 16 2003 7:02AM" } ,
6448 text
"Variation in capacity for acetylation of 4ABP and PABA resulting
6449 from human NAT1 transgene is insufficient to affect 4ABP genotoxicity in
6455 str
"Sep 6 2003 12:00AM" ,
6457 str
"Sep 14 2003 7:01AM" } ,
6460 text
"It is unlikely that the NAT1*10 or NAT2 rapid/intermediate
6461 genotypes are related to stomach cancer risk." ,
6466 str
"Sep 4 2003 12:00AM" ,
6468 str
"Sep 28 2003 7:01AM" } ,
6471 text
"genetic polymorphisms of NAT1 and NAT2 have no independent effect
6472 on breast cancer risk, but they modulate breast cancer risk in the presence
6473 of GSTM1 and GSTT1 null genotypes." ,
6478 str
"Aug 18 2003 12:00AM" ,
6480 str
"Aug 24 2003 7:01AM" } ,
6483 text
"NAT1 * 10 has increased risk of sporadic colorectal adenocarcinoma
6484 and significantly related to the later stage tumors, is not significantly
6485 related to the tumor location" ,
6490 str
"Jun 25 2003 12:00AM" ,
6492 str
"Jul 13 2003 7:01AM" } ,
6495 text
"Single nucleotide polymorphisms of NAT1 and NAT2, and acetylation
6496 haplotype were not associated with increased risk for Parkinson disease" ,
6501 str
"Apr 11 2003 12:00AM" ,
6503 str
"Apr 27 2003 7:01AM" } ,
6506 text
"NAT1 polymorphism (NAT1*10) indicates increased susceptibility to
6512 str
"Oct 31 2002 12:00AM" ,
6514 str
"Feb 2 2003 7:01AM" } ,
6517 text
"susceptibility gene for multifactorial adverse effects and
6518 xenobiotic-related diseases (review)" ,
6523 str
"Sep 12 2002 12:00AM" ,
6525 str
"Sep 16 2002 5:48AM" } ,
6528 text
"NAT1 genotype acts as a modifier of diisothionate
6529 exposure-associated asthma risk" ,
6534 str
"Aug 30 2002 12:00AM" ,
6536 str
"Sep 16 2002 5:48AM" } ,
6539 text
"NAT1 polymorphisms may be correlated with an increased risk of
6545 str
"Aug 19 2002 12:00AM" ,
6547 str
"Aug 28 2002 6:15PM" } ,
6550 text
"paclitaxel affected human leukemia HL-60 cells arylamine
6551 N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adduct formation." ,
6556 str
"Jun 19 2002 12:00AM" ,
6558 str
"Jun 24 2002 6:31AM" } ,
6561 text
"paclitaxel is an uncompetitive inhibitor to arylamine
6562 N-acetyltransferase (NAT) enzyme" ,
6567 str
"Jun 19 2002 12:00AM" ,
6569 str
"Jun 24 2002 6:31AM" } } ,
6601 type protein
-coding
,
6606 taxname
"Homo sapiens" ,
6619 species
"sapiens" } ,
6620 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
6621 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
6628 subtype chromosome
,
6632 desc
"N-acetyltransferase 2 (arylamine N-acetyltransferase)" ,
6641 locus
-tag
"HGNC:7646" } ,
6644 "arylamide acetylase 2" ,
6645 "Arylamine N-acetyltransferase-2" ,
6646 "arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation)" } } ,
6647 summary
"The intronless NAT2 gene encodes N-acetyltransferase 2 (arylamine
6648 N-acetyltransferase 2). This enzyme functions to both activate and deactivate
6649 arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are
6650 reponsible for the N-acetylation polymorphism in which human populations
6651 segregate into rapid,intermediate, and slow acetylator phenotypes.
6652 Polymorphisms in NAT2 are also associated with higher incidences of cancer
6653 and drug toxicity.A second arylamine N-acetyltransferase gene (NAT1) is
6654 located near NAT2." ,
6657 display-str
"8p22" ,
6664 gene
-display FALSE
,
6665 locus
-display FALSE
,
6666 extra
-terms FALSE
} ,
6670 heading
"Reference" ,
6671 accession
"NC_000008" ,
6683 heading
"Reference" ,
6684 accession
"NM_000015" ,
6706 heading
"Reference" ,
6707 accession
"NP_000006" ,
6728 value
"2.3.1.5" } } } } } } } } } ,
6731 heading
"Reference" ,
6732 accession
"NT_030737" ,
6744 heading
"Reference" ,
6745 accession
"NM_000015" ,
6767 heading
"Reference" ,
6768 accession
"NP_000006" ,
6789 value
"2.3.1.5" } } } } } } } } } ,
6792 heading
"Reference" ,
6793 accession
"NT_086740" ,
6805 heading
"Reference" ,
6806 accession
"NM_000015" ,
6828 heading
"Reference" ,
6829 accession
"NP_000006" ,
6850 value
"2.3.1.5" } } } } } } } } } } ,
6854 label
"Nomenclature" ,
6858 anchor
"HUGO Gene Nomenclature Committee" } } ,
6862 label
"Official Symbol" ,
6867 label
"Official Full Name" ,
6868 text
"N-acetyltransferase 2 (arylamine N-acetyltransferase)" ,
6872 heading
"GeneOntology" ,
6876 pre
-text
"Provided by" ,
6878 url
"http://www.ebi.ac.uk/GOA/" } } ,
6894 anchor
"acetyltransferase activity" ,
6895 post
-text
"evidence: IEA" } } } ,
6907 anchor
"arylamine N-acetyltransferase activity" ,
6908 post
-text
"evidence: TAS" } } } ,
6918 anchor
"transferase activity" ,
6919 post
-text
"evidence: IEA" } } } } } ,
6934 anchor
"metabolism" ,
6935 post
-text
"evidence: IEA" } } } } } } } } ,
6939 heading
"Mouse, Rat" ,
6947 anchor
"Map Viewer" ,
6948 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=8&M
6949 APS=genes-r-org/rat-chr/human%3A8,genes-r-org/mouse-chr/human%3A8,genes-r-org/
6950 human-chr8&query=e%3A10[id]+AND+gene[obj_type]&QSTR=nat2&cmd=focus&fill=10" } } } } ,
6954 heading
"LocusTagLink" ,
6964 heading
"RefSeq Status" ,
7031 heading
"Markers (Sequence Tagged Sites/STS)" ,
7044 post
-text
"(e-PCR)" } } ,
7048 label
"Alternate name" ,
7060 anchor
"WIAF-2120" ,
7061 post
-text
"(e-PCR)" } } ,
7065 label
"Alternate name" ,
7070 label
"Alternate name" ,
7075 label
"Alternate name" ,
7076 text
"WIAF-2120-STS" ,
7080 label
"Alternate name" ,
7081 text
"gdb:4559542" ,
7085 label
"Alternate name" ,
7098 post
-text
"(e-PCR)" } } ,
7102 label
"Alternate name" ,
7103 text
"SHGC-130680" ,
7114 anchor
"GDB:187676" ,
7115 post
-text
"(e-PCR)" } } } ,
7125 anchor
"GDB:310612" ,
7126 post
-text
"(e-PCR)" } } } ,
7136 anchor
"GDB:310613" ,
7137 post
-text
"(e-PCR)" } } } ,
7147 anchor
"GDB:386004" ,
7148 post
-text
"(e-PCR)" } } } ,
7158 anchor
"PMC310725P3" ,
7159 post
-text
"(e-PCR)" } } } } } ,
7162 heading
"NCBI Reference Sequences (RefSeq)" ,
7167 heading
"mRNA Sequence" ,
7168 accession
"NM_000015" ,
7176 anchor
"NM_000015" } } ,
7184 accession
"NP_000006" ,
7192 anchor
"NP_000006" ,
7193 post
-text
"arylamide acetylase 2" } } ,
7200 heading
"Consensus CDS (CCDS)" ,
7207 str
"CCDS6008.1" } ,
7208 anchor
"CCDS6008.1" } } } ,
7211 heading
"Conserved Domains" ,
7220 anchor
"summary" } } ,
7231 anchor
"pfam00797: Acetyltransf_2;
7232 N-acetyltransferase" } } ,
7236 text
"Location: 20 - 280 Blast Score: 1005" ,
7237 version
0 } } } } } } } } ,
7241 heading
"Source Sequence" ,
7249 anchor
"D90042" } } ,
7253 version
0 } } } } } } } ,
7256 heading
"Related Sequences" ,
7262 accession
"AF042740" ,
7270 anchor
"AF042740" } } ,
7277 accession
"AAC03773" ,
7285 anchor
"AAC03773" } } ,
7288 gi
2801807 } } } } ,
7292 accession
"AF055874" ,
7300 anchor
"AF055874" } } ,
7307 accession
"AAC14117" ,
7315 anchor
"AAC14117" } } ,
7318 gi
3063614 } } } } ,
7322 accession
"AF055875" ,
7330 anchor
"AF055875" } } ,
7337 accession
"AAC14118" ,
7345 anchor
"AAC14118" } } ,
7348 gi
3063616 } } } } ,
7352 accession
"AF320309" ,
7360 anchor
"AF320309" } } ,
7367 accession
"AAG34181" ,
7375 anchor
"AAG34181" } } ,
7378 gi
11321495 } } } } ,
7382 accession
"AF348074" ,
7390 anchor
"AF348074" } } ,
7397 accession
"AAK51710" ,
7405 anchor
"AAK51710" } } ,
7408 gi
14009676 } } } } ,
7412 accession
"AF348075" ,
7420 anchor
"AF348075" } } ,
7427 accession
"AAK51711" ,
7435 anchor
"AAK51711" } } ,
7438 gi
14009678 } } } } ,
7442 accession
"AY230251" ,
7450 anchor
"AY230251" } } ,
7457 accession
"AAO73561" ,
7465 anchor
"AAO73561" } } ,
7468 gi
29423786 } } } } ,
7472 accession
"AY230252" ,
7480 anchor
"AY230252" } } ,
7487 accession
"AAO73562" ,
7495 anchor
"AAO73562" } } ,
7498 gi
29423790 } } } } ,
7502 accession
"AY331807" ,
7510 anchor
"AY331807" } } ,
7517 accession
"AAP81164" ,
7525 anchor
"AAP81164" } } ,
7528 gi
32402491 } } } } ,
7532 accession
"D10870" ,
7540 anchor
"D10870" } } ,
7547 accession
"BAA01640" ,
7555 anchor
"BAA01640" } } ,
7562 accession
"D10871" ,
7570 anchor
"D10871" } } ,
7577 accession
"BAA01641" ,
7585 anchor
"BAA01641" } } ,
7592 accession
"D10872" ,
7600 anchor
"D10872" } } ,
7607 accession
"BAA01642" ,
7615 anchor
"BAA01642" } } ,
7622 accession
"M75163" ,
7630 anchor
"M75163" } } ,
7637 accession
"AAA59906" ,
7645 anchor
"AAA59906" } } ,
7652 accession
"M75164" ,
7660 anchor
"M75164" } } ,
7667 accession
"AAA59905" ,
7675 anchor
"AAA59905" } } ,
7682 accession
"U23052" ,
7690 anchor
"U23052" } } ,
7697 accession
"AAA64584" ,
7705 anchor
"AAA64584" } } ,
7712 accession
"U23434" ,
7720 anchor
"U23434" } } ,
7727 accession
"AAA64585" ,
7735 anchor
"AAA64585" } } ,
7742 accession
"U53473" ,
7750 anchor
"U53473" } } ,
7757 accession
"AAA98976" ,
7765 anchor
"AAA98976" } } ,
7768 gi
1297332 } } } } ,
7772 accession
"X14672" ,
7780 anchor
"X14672" } } ,
7787 accession
"CAA32802" ,
7795 anchor
"CAA32802" } } ,
7802 accession
"BC015878" ,
7810 anchor
"BC015878" } } ,
7817 accession
"AAH15878" ,
7825 anchor
"AAH15878" } } ,
7828 gi
16198420 } } } } ,
7832 accession
"BC067218" ,
7840 anchor
"BC067218" } } ,
7847 accession
"AAH67218" ,
7855 anchor
"AAH67218" } } ,
7858 gi
45501307 } } } } ,
7862 accession
"CR407631" ,
7870 anchor
"CR407631" } } ,
7877 accession
"CAG28559" ,
7885 anchor
"CAG28559" } } ,
7888 gi
47115199 } } } } ,
7892 accession
"D90040" ,
7900 anchor
"D90040" } } ,
7907 accession
"BAA14094" ,
7915 anchor
"BAA14094" } } ,
7922 accession
"D90042" ,
7930 anchor
"D90042" } } ,
7937 accession
"BAA14096" ,
7945 anchor
"BAA14096" } } ,
7956 accession
"P11245" ,
7964 anchor
"P11245" } } ,
7967 gi
114238 } } } } } } ,
7970 heading
"Additional Links" ,
7979 db
"Evidence Viewer" ,
7982 anchor
"Evidence Viewer" ,
7983 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
7984 g=NT_030737.9&gene=NAT2&lid=10&from=6093683&to=6103610" } } } ,
7994 anchor
"ModelMaker" ,
7995 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
7996 06&contig=NT_030737.9&gene=NAT2&lid=10" } } } ,
8012 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2" } } } ,
8023 anchor
"243400" } } } ,
8034 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
8035 ocusid&org=9606&l=10" } } } ,
8044 str
"GDB:125365" } } } } ,
8054 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=BC067
8065 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
8077 anchor
"PA18" } } } ,
8080 text
"Arylamine N-Acetyltransferase Nomenclature" ,
8085 db
"Arylamine N-Acetyltransferase Nomenclature" ,
8087 str
"Arylamine N-Acetyltransferase Nomenclature" } ,
8088 anchor
"Arylamine N-Acetyltransferase Nomenclature" ,
8089 url
"http://www.louisville.edu/medschool/pharmacology/NAT.html" } } } ,
8098 str
"BC015878,BC067218" } ,
8100 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC015878
8101 ,BC067218" } } } } } ,
8104 text
"there is no association between endometriosis and NAT2 in South
8110 str
"Mar 19 2005 10:01AM" ,
8112 str
"Mar 19 2005 11:47AM" } ,
8115 text
"Risks for colorectal cancer are significantly associated with the
8116 genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and
8117 genotye and NAT2-rapid acetylator phenotype." ,
8122 str
"Mar 7 2005 7:07PM" ,
8124 str
"Mar 8 2005 12:10AM" } ,
8127 text
"Cigarette smoking is associated with increased risk of breast
8128 cancer in women with the NAT2 slow acetylator genotype." ,
8133 str
"Nov 13 2004 10:01AM" ,
8135 str
"Nov 13 2004 10:50AM" } ,
8138 text
"N-acetyltransferase 2 polymorphism does not play an important role
8139 in breast cancer risk of Turkish women by altering the capacity in
8140 deactivation of environmental carcinogens" ,
8145 str
"Oct 4 2004 10:33AM" ,
8147 str
"Oct 4 2004 11:19AM" } ,
8150 text
"NAT2 slow acetylator genotypes might modulate the effect of
8151 carcinogenic arylamines contained in tobacco smoke." ,
8156 str
"Sep 27 2004 4:34PM" ,
8158 str
"Sep 27 2004 5:11PM" } ,
8161 text
"Arylamine N-acetyltransferase 2 is a genetically polymorphic phase
8162 II enzyme with a role in the metabolism of many xenobiotics." ,
8167 str
"Aug 2 2004 1:09PM" ,
8169 str
"Aug 2 2004 1:38PM" } ,
8172 text
"although there is little overall association between NAT genotypes
8173 and risk of developing systemic lupus erythematosus, the interaction between
8174 NAT1 and NAT2 and specific exposures such as hair dyes may be important" ,
8179 str
"Apr 16 2004 12:00AM" ,
8181 str
"May 2 2004 7:01AM" } ,
8184 text
"The NAT2 acetylator genotype may modify esophageal cancer risk in
8185 humans from exposure to barbecued/grilled meat." ,
8190 str
"Feb 13 2004 12:00AM" ,
8192 str
"Feb 22 2004 7:01AM" } ,
8195 text
"N-acetyltransferase 2 polymorphism does not differ between
8196 patients suffering from atopic dermatitis and healthy subjects" ,
8201 str
"Feb 5 2004 12:00AM" ,
8203 str
"Feb 15 2004 6:33PM" } ,
8206 text
"Genetic NAT2 polymorphism may play a role in lifestyle
8207 factors-related hepato- carcinogenesis, particulary critical in smoking
8208 related hepatocarcinogenesis." ,
8213 str
"Feb 4 2004 12:00AM" ,
8215 str
"Feb 15 2004 6:32PM" } ,
8218 text
"Slow acetylation activity is associated with age-related cataract
8224 str
"Jan 6 2004 12:00AM" ,
8226 str
"Feb 22 2004 7:01AM" } ,
8229 text
"A significant association between Parkinson disease & the slow
8230 acetylator genotype for N-acetyltransferase 2 in Hong Kong Chinesed provides
8231 evidence for a possible functional relationship between NAT2 slow acetylator
8232 genotype & PD in both racial groups." ,
8237 str
"Dec 23 2003 12:00AM" ,
8239 str
"Jan 18 2004 7:01AM" } ,
8242 text
"RFLP of the gene coding for N-acetyltransferase 2 (NAT2) was typed
8243 in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes,
8244 Udmurts, and Russians) and in patients with chronic obstructive pulmonary
8245 disease (COPD) and in healthy individuals" ,
8250 str
"Dec 18 2003 12:00AM" ,
8252 str
"Jan 25 2004 7:01AM" } ,
8255 text
"We conclude that smoking increases risk of colorectal adenomas and
8256 that SULT1A1 and NAT2 only modestly modify this association." ,
8261 str
"Dec 11 2003 12:00AM" ,
8263 str
"Dec 21 2003 7:01AM" } ,
8266 text
"In human, NAT2 polymorphism may be a genetic risk factor for joint
8272 str
"May 7 2004 12:00AM" ,
8274 str
"May 16 2004 7:01AM" } ,
8277 text
"It is unlikely that the NAT1*10 or NAT2 rapid/intermediate
8278 genotypes are related to stomach cancer risk." ,
8283 str
"Sep 4 2003 12:00AM" ,
8285 str
"Sep 28 2003 7:01AM" } ,
8288 text
"genetic polymorphisms of NAT1 and NAT2 have no independent effect
8289 on breast cancer risk, but they modulate breast cancer risk in the presence
8290 of GSTM1 and GSTT1 null genotypes." ,
8295 str
"Aug 18 2003 12:00AM" ,
8297 str
"Aug 24 2003 7:01AM" } ,
8300 text
"NAT2 slow acetylator genotype plays an important role in
8301 determining the risk of developing prostate cancer in Japanese men and is
8302 also associated with more clinically advanced and pathologically aggressive
8308 str
"Aug 9 2003 12:00AM" ,
8310 str
"Aug 24 2003 7:01AM" } ,
8313 text
"Polymorphism of Nat2 encoding phase 2 xenobiotic detoxication
8314 enzyme was studied." ,
8319 str
"Jun 26 2003 12:00AM" ,
8321 str
"Aug 10 2003 7:01AM" } ,
8324 text
"This enzyme is polymorphic in various ethnic populations of South
8330 str
"May 24 2003 12:00AM" ,
8332 str
"Jul 27 2003 7:01AM" } ,
8335 text
"Maternal NAT2 acetylator status seems not to be an important
8336 factor in the etiology of orofacial clefts." ,
8341 str
"May 7 2003 12:00AM" ,
8343 str
"Jun 1 2003 7:01AM" } ,
8346 text
"Genotyping the NAT2 gene and estimating diplotype configuration
8347 before administration of SSZ may reduce the frequency of adverse effects in
8348 Japanese patients with RA." ,
8353 str
"May 2 2003 12:00AM" ,
8355 str
"May 11 2003 7:01AM" } ,
8358 text
"Single nucleotide polymorphisms of NAT1 and NAT2, and acetylation
8359 haplotype were not associated with increased risk for Parkinson disease" ,
8364 str
"Apr 11 2003 12:00AM" ,
8366 str
"Apr 27 2003 7:01AM" } ,
8369 text
"lack of association between polymorphism of this gene and systemic
8370 lupus erythematosus" ,
8375 str
"Apr 9 2003 12:00AM" ,
8377 str
"Apr 27 2003 7:01AM" } ,
8380 text
"Polymorphic N-acetyltransferase (NAT2) is involved in the
8381 metabolism of several compounds relevant in pharmacology or toxicology, with
8382 diverse clinical consequences--review" ,
8387 str
"Mar 24 2003 12:00AM" ,
8389 str
"Mar 31 2003 6:30AM" } ,
8392 text
"N-acetyltransferase 2*19 possessing the C190T (R64W) single
8393 nucleotide polymorphisms encodes a slow acetylator phenotype for both N- and
8394 O-acetylation, due to a reduction in the amount and stability of the NAT2 19
8400 str
"Mar 10 2003 12:00AM" ,
8402 str
"Apr 13 2003 7:01AM" } ,
8405 text
"NAT2 slow acetylation and GSTM1 null genotypes may increase
8406 postmenopausal breast cancer risk in long-term smoking women." ,
8411 str
"Mar 7 2004 12:00AM" ,
8413 str
"Apr 18 2004 7:02AM" } ,
8416 text
"A slow acetylator genotype of this enzyme is associated with an
8417 increased risk of advanced cervical cancer." ,
8422 str
"Feb 27 2003 12:00AM" ,
8424 str
"Apr 13 2003 7:01AM" } ,
8427 text
"Women with the GSTT1 null genotype were found to have a
8428 significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8),
8429 while GSTM1 and NAT2 genotypes were not associated with breast cancer risk." ,
8434 str
"Nov 25 2002 12:00AM" ,
8436 str
"Feb 2 2003 7:01AM" } ,
8439 text
"NAT2 slow genotype with NAT1 polymorphism indicates increased
8440 susceptibility to prostate cancer" ,
8445 str
"Oct 31 2002 12:00AM" ,
8447 str
"Feb 2 2003 7:01AM" } ,
8450 text
"NAT2 slow acetylation genotype may be a risk factor of individual
8451 susceptibility to rheumatoid arthritis." ,
8456 str
"Oct 7 2002 12:00AM" ,
8458 str
"Feb 2 2003 7:01AM" } ,
8461 text
"NAT2 acetylator status can influence susceptibility to breast
8462 cancer after exposure to tobacco smoke carcinogens; effect appears to be
8463 differential for active and passive smoke exposure" ,
8468 str
"Sep 7 2002 12:00AM" ,
8470 str
"Sep 16 2002 5:48AM" } ,
8473 text
"NAT2 polymorphisms may be correlated with an increased risk of
8479 str
"Aug 19 2002 12:00AM" ,
8481 str
"Aug 28 2002 6:15PM" } ,
8484 text
"The combined effect of N-acetyltransferase 2 (NAT2) slow genotype
8485 and exposure to smoking is observed during the development of laryngeal
8491 str
"Aug 9 2002 12:00AM" ,
8493 str
"Sep 16 2002 5:48AM" } ,
8496 text
"urinary excretion of
8497 N(2)-(beta-1-glucos-iduronyl)-2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]p
8498 yridine relationship to activity levels of NAT2" ,
8503 str
"Jun 12 2002 12:00AM" ,
8505 str
"Jun 24 2002 6:31AM" } ,
8508 text
"Polymorphism of the N-acetyltransferase 2 gene as a susceptibility
8509 risk factor for antituberculosis drug-induced hepatitis." ,
8514 str
"Apr 15 2002 12:00AM" ,
8516 str
"Apr 28 2002 6:17PM" } ,
8519 text
"Association between bone loss in periodontal disease and
8520 polymorphism of N-acetyltransferase (NAT2)" ,
8525 str
"Apr 9 2002 12:00AM" ,
8527 str
"May 14 2002 5:48AM" } ,
8530 text
"we investigated the relationship between the levels of aromatic
8531 DNA adducts in breast tissues and polymorphisms of the drug-metabolizing
8532 genes CYP1A1, NAT2, and GSTM1 in 166 women having breast cancer" ,
8537 str
"Apr 2 2002 12:00AM" ,
8539 str
"Apr 8 2002 3:24PM" } } ,
8576 taxname
"Homo sapiens" ,
8589 species
"sapiens" } ,
8590 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
8591 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
8598 subtype chromosome
,
8602 desc
"arylamide acetylase pseudogene" ,
8606 locus
-tag
"HGNC:15" } ,
8609 display-str
"8p22" ,
8616 gene
-display FALSE
,
8617 locus
-display FALSE
,
8618 extra
-terms FALSE
} ,
8626 label
"Nomenclature" ,
8630 anchor
"HUGO Gene Nomenclature Committee" } } ,
8634 label
"Official Symbol" ,
8639 label
"Official Full Name" ,
8640 text
"arylamide acetylase pseudogene" ,
8645 heading
"LocusTagLink" ,
8660 heading
"Related Sequences" ,
8666 accession
"X17060" ,
8674 anchor
"X17060" } } ,
8682 version
0 } } } } } ,
8685 heading
"Additional Links" ,
8696 str
"GDB:132838" } } } } } } } ,
8724 type protein
-coding
,
8729 taxname
"Homo sapiens" ,
8742 species
"sapiens" } ,
8743 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
8744 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
8751 subtype chromosome
,
8755 desc
"serine (or cysteine) proteinase inhibitor, clade A (alpha-1
8756 antiproteinase, antitrypsin), member 3" ,
8767 locus
-tag
"HGNC:16" } ,
8770 "serine (or cysteine) proteinase inhibitor, clade A, member 3" ,
8771 "antichymotrypsin" ,
8772 "alpha-1-antichymotrypsin" ,
8773 "serine (or cysteine) proteinase inhibitor, clade A, member 3" } } ,
8774 summary
"The protein encoded by this gene is a plasma protease inhibitor and
8775 member of the serine protease inhibitor class. Polymorphisms in this protein
8776 appear to be tissue specific and influence protease targeting. Variation in
8777 this protein's sequence have been implicated in Alzheimer's disease, and
8778 deficiency of this protein has been associated with liver disease. Mutations
8779 have been identified in patients with Parkinson disease and chronic
8780 obstructive pulmonary disease." ,
8783 display-str
"14q32.1" ,
8790 gene
-display FALSE
,
8791 locus
-display FALSE
,
8792 extra
-terms FALSE
} ,
8796 heading
"Reference" ,
8797 accession
"NC_000014" ,
8809 heading
"Reference" ,
8810 accession
"NM_001085" ,
8844 heading
"Reference" ,
8846 accession
"NP_001076" ,
8876 gi
4501843 } } } } } } ,
8879 heading
"Reference" ,
8880 accession
"NT_026437" ,
8892 heading
"Reference" ,
8893 accession
"NM_001085" ,
8927 heading
"Reference" ,
8929 accession
"NP_001076" ,
8959 gi
4501843 } } } } } } ,
8962 heading
"Reference" ,
8963 accession
"NT_086807" ,
8975 heading
"Reference" ,
8976 accession
"NM_001085" ,
9010 heading
"Reference" ,
9012 accession
"NP_001076" ,
9042 gi
4501843 } } } } } } } ,
9046 label
"Nomenclature" ,
9050 anchor
"HUGO Gene Nomenclature Committee" } } ,
9054 label
"Official Symbol" ,
9059 label
"Official Full Name" ,
9060 text
"serine (or cysteine) proteinase inhibitor, clade A (alpha-1
9061 antiproteinase, antitrypsin), member 3" ,
9065 heading
"GeneOntology" ,
9069 pre
-text
"Provided by" ,
9071 url
"http://www.ebi.ac.uk/GOA/" } } ,
9089 anchor
"DNA binding" ,
9090 post
-text
"evidence: IC" } } } ,
9102 anchor
"chymotrypsin inhibitor activity" ,
9103 post
-text
"evidence: NAS" } } } ,
9115 anchor
"protein binding" ,
9116 post
-text
"evidence: IPI" } } } ,
9126 anchor
"serine-type endopeptidase inhibitor activity" ,
9127 post
-text
"evidence: IEA" } } } } } ,
9142 anchor
"acute-phase response" ,
9143 post
-text
"evidence: IEA" } } } ,
9155 anchor
"inflammatory response" ,
9156 post
-text
"evidence: NAS" } } } ,
9168 anchor
"regulation of lipid metabolism" ,
9169 post
-text
"evidence: NAS" } } } ,
9179 anchor
"transport" ,
9180 post
-text
"evidence: IEA" } } } } } ,
9198 anchor
"extracellular region" ,
9199 post
-text
"evidence: NAS" } } } ,
9211 anchor
"intracellular" ,
9212 post
-text
"evidence: NAS" } } } ,
9223 post
-text
"evidence: IEA" } } } } } } } } ,
9227 heading
"Mouse, Rat" ,
9235 anchor
"Map Viewer" ,
9236 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=14&
9237 MAPS=genes-r-org/rat-chr/human%3A14,genes-r-org/mouse-chr/human%3A14,genes-r-o
9238 rg/human-chr14&query=e%3A12[id]+AND+gene[obj_type]&QSTR=serpina3&cmd=focus&fil
9243 heading
"LocusTagLink" ,
9253 heading
"RefSeq Status" ,
9338 heading
"Phenotypes" ,
9343 text
"Alpha-1-antichymotrypsin deficiency" ,
9351 anchor
"MIM: 107280" } } } ,
9354 text
"Cerebrovascular disease, occlusive" ,
9362 anchor
"MIM: 107280" } } } } } ,
9365 heading
"Markers (Sequence Tagged Sites/STS)" ,
9378 post
-text
"(e-PCR)" } } ,
9382 label
"Alternate name" ,
9387 label
"Alternate name" ,
9399 anchor
"SHGC-32982" ,
9400 post
-text
"(e-PCR)" } } ,
9404 label
"Alternate name" ,
9409 label
"Alternate name" ,
9414 label
"Alternate name" ,
9419 label
"Alternate name" ,
9432 post
-text
"(e-PCR)" } } ,
9436 label
"Alternate name" ,
9441 label
"Alternate name" ,
9446 label
"Alternate name" ,
9451 label
"Alternate name" ,
9464 post
-text
"(e-PCR)" } } ,
9468 label
"Alternate name" ,
9481 post
-text
"(e-PCR)" } } ,
9485 label
"Alternate name" ,
9498 post
-text
"(e-PCR)" } } ,
9502 label
"Alternate name" ,
9514 anchor
"PMC27764P1" ,
9515 post
-text
"(e-PCR)" } } } } } ,
9518 heading
"NCBI Reference Sequences (RefSeq)" ,
9523 heading
"mRNA Sequence" ,
9524 accession
"NM_001085" ,
9532 anchor
"NM_001085" } } ,
9540 accession
"NP_001076" ,
9548 anchor
"NP_001076" ,
9549 post
-text
"serine (or cysteine) proteinase inhibitor, clade
9550 A, member 3 precursor" } } ,
9557 heading
"Conserved Domains" ,
9566 anchor
"summary" } } ,
9577 anchor
"cd02056: alpha-1-antitrypsin_like;
9578 alpha-1-antitrypsin_like" } } ,
9582 text
"Location: 52 - 417 Blast Score: 1367" ,
9583 version
0 } } } } } } } } ,
9587 heading
"Source Sequence" ,
9594 str
"BC003559,BG565041" } ,
9595 anchor
"BC003559,BG565041" } } ,
9599 version
0 } } } } } } } ,
9602 heading
"Related Sequences" ,
9608 accession
"X00947" ,
9616 anchor
"X00947" } } ,
9623 accession
"CAA25459" ,
9631 anchor
"CAA25459" } } ,
9638 accession
"X68733" ,
9646 anchor
"X68733" } } ,
9653 accession
"CAA48671" ,
9661 anchor
"CAA48671" } } ,
9664 gi
1340142 } } } } ,
9668 accession
"AB209060" ,
9676 anchor
"AB209060" } } ,
9683 accession
"BAD92297" ,
9691 anchor
"BAD92297" } } ,
9694 gi
62087700 } } } } ,
9698 accession
"AF089747" ,
9706 anchor
"AF089747" } } ,
9713 accession
"AAD08810" ,
9721 anchor
"AAD08810" } } ,
9724 gi
4165890 } } } } ,
9728 accession
"AK093049" ,
9736 anchor
"AK093049" } } ,
9748 accession
"AK096120" ,
9756 anchor
"AK096120" } } ,
9768 accession
"AK123091" ,
9776 anchor
"AK123091" } } ,
9788 accession
"BC003559" ,
9796 anchor
"BC003559" } } ,
9803 accession
"AAH03559" ,
9811 anchor
"AAH03559" } } ,
9814 gi
13097705 } } } } ,
9818 accession
"BC010530" ,
9826 anchor
"BC010530" } } ,
9833 accession
"AAH10530" ,
9841 anchor
"AAH10530" } } ,
9844 gi
14714766 } } } } ,
9848 accession
"BC013189" ,
9856 anchor
"BC013189" } } ,
9863 accession
"AAH13189" ,
9871 anchor
"AAH13189" } } ,
9874 gi
15341985 } } } } ,
9878 accession
"BC034554" ,
9886 anchor
"BC034554" } } ,
9893 accession
"AAH34554" ,
9901 anchor
"AAH34554" } } ,
9904 gi
21961493 } } } } ,
9908 accession
"BC070265" ,
9916 anchor
"BC070265" } } ,
9923 accession
"AAH70265" ,
9931 anchor
"AAH70265" } } ,
9934 gi
47124538 } } } } ,
9938 accession
"BG565041" ,
9946 anchor
"BG565041" } } ,
9958 accession
"J05176" ,
9966 anchor
"J05176" } } ,
9973 accession
"AAA51560" ,
9981 anchor
"AAA51560" } } ,
9988 accession
"K01500" ,
9996 anchor
"K01500" } } ,
10003 accession
"AAA51543" ,
10011 anchor
"AAA51543" } } ,
10014 gi
177809 } } } } ,
10018 accession
"M18906" ,
10026 anchor
"M18906" } } ,
10033 accession
"AAA51559" ,
10041 anchor
"AAA51559" } } ,
10044 gi
177931 } } } } ,
10052 accession
"P01011" ,
10060 anchor
"P01011" } } ,
10063 gi
112874 } } } } } } ,
10066 heading
"Additional Links" ,
10075 db
"Evidence Viewer" ,
10078 anchor
"Evidence Viewer" ,
10079 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
10080 g=NT_026437.11&gene=SERPINA3&lid=12&from=76080524&to=76090144" } } } ,
10090 anchor
"ModelMaker" ,
10091 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
10092 06&contig=NT_026437.11&gene=SERPINA3&lid=12" } } } ,
10100 value
"Hs.534293" } } ,
10106 str
"Hs.534293" } ,
10107 anchor
"Hs.534293" ,
10108 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=53
10120 anchor
"107280" } } } ,
10130 anchor
"HomoloGene" ,
10131 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
10132 12[loc]&TAXID=9606" } } } ,
10143 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
10144 ocusid&org=9606&l=12" } } } ,
10153 str
"GDB:118955" } } } } ,
10163 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=AK093
10174 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
10185 url
"http://www.genome.ad.jp/dbget-bin/www_bget?hsa:12" } } } ,
10194 str
"BC003559,BC010530,BC034554" } ,
10196 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC003559
10197 ,BC010530,BC034554" } } } } } ,
10200 heading
"Pathways" ,
10205 text
"KEGG pathway: Alzheimer's disease" ,
10214 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa05010+12" } } } } } ,
10217 text
"overexpression of ACT by astrocytes could thus contribute to
10218 increased beta-amyloid fibril formation in Alzheimer's disease" ,
10223 str
"Jan 29 2005 10:01AM" ,
10225 str
"Jan 29 2005 1:54PM" } ,
10228 text
"Multivariate analysis showed that ACT mRNA level, but not STC2
10229 mRNA level, in HR-positive patients, was a significant prognostic factor (P =
10230 0.042), which was independent of tumor size and lymph node metastases." ,
10235 str
"Jan 15 2005 10:01AM" ,
10237 str
"Jan 15 2005 4:35PM" } ,
10240 text
"Alpha1-antichymotrypsin-AA may confer a modest protection against
10241 developing early-onset Parkinson disease in women" ,
10246 str
"Jan 15 2005 10:01AM" ,
10248 str
"Jan 15 2005 1:01PM" } ,
10251 text
"Polymeric AACT specifically seeds the polymerization of native
10252 protein by a serpin-dependent process that occurs under physiological
10253 conditions and may be important in the deposition of AACT in plaques in
10254 patients with Alzheimer's disease." ,
10259 str
"May 26 2003 12:00AM" ,
10261 str
"Jun 1 2003 7:01AM" } ,
10264 text
"alpha(1)-antichymotrypsin polymorphism: a risk factor for
10265 hemorrhagic stroke in normotensive subjects." ,
10270 str
"Mar 5 2003 12:00AM" ,
10272 str
"Mar 23 2003 7:01AM" } ,
10275 text
"alpha(1)-antitrypsin and antichymotrypsin are produced by the
10276 mammary gland and are present in milk in relatively high amounts in early
10282 str
"Oct 11 2002 12:00AM" ,
10284 str
"Feb 2 2003 7:01AM" } ,
10287 text
"Gene regulation of the serine proteinase inhibitors
10288 alpha1-antitrypsin and alpha1-antichymotrypsin." ,
10293 str
"Oct 9 2002 12:00AM" ,
10295 str
"Feb 2 2003 7:01AM" } ,
10298 text
"data suggested that the ApoE epsilon2/epsilon4 genotype might be a
10299 susceptibility variant of moderate effect for sporadic idiopathic Parkinson
10300 disease in our samples, whereas the ACT gene signal peptide polymorphism
10306 str
"Sep 26 2002 12:00AM" ,
10308 str
"Oct 7 2002 8:10AM" } ,
10311 text
"no association seen between alpha 1-antichymotrypsin and time to
10312 psychosis in Alzheimer's disease" ,
10317 str
"Aug 28 2002 12:00AM" ,
10319 str
"Sep 16 2002 5:48AM" } ,
10322 text
"significantly higher in plasma of Alzheimer patients compared to
10328 str
"Jul 22 2002 12:00AM" ,
10330 str
"Jul 29 2002 6:27PM" } ,
10333 text
"A25G and G39A substitutions in the AACT gene are probably one of
10334 the risk factors to Alzheimer's disease (AD) in Han Chinese." ,
10339 str
"Apr 7 2002 12:00AM" ,
10341 str
"Apr 13 2002 5:25PM" } ,
10344 heading
"Interactions" ,
10349 text
"Alpha-1 ACT interacts with and inhibits cathepsin G." ,
10359 anchor
"BIND" } } ,
10364 accession
"NP_001076" ,
10369 accession
"NP_001902" ,
10376 id
1511 } } } } } ,
10378 str
"2005-01-21 20:10 EDT" ,
10380 str
"2005-01-21 20:19 EDT" } ,
10383 text
"LRP interacts with alpha-1-ACT." ,
10393 anchor
"BIND" } } ,
10398 accession
"NP_001076" ,
10403 accession
"NP_002323" ,
10410 id
4035 } } } } } ,
10412 str
"2005-01-21 20:10 EDT" ,
10414 str
"2005-01-21 20:19 EDT" } } } } ,
10429 value
"phenotype" } } }
10450 type protein
-coding
,
10455 taxname
"Homo sapiens" ,
10468 species
"sapiens" } ,
10469 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
10470 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
10477 subtype chromosome
,
10481 desc
"arylacetamide deacetylase (esterase)" ,
10482 maploc
"3q21.3-q25.2" ,
10490 locus
-tag
"HGNC:17" } ,
10493 "arylacetamide deacetylase" } } ,
10494 summary
"Microsomal arylacetamide deacetylase competes against the activity
10495 of cytosolic arylamine N-acetyltransferase, which catalyzes one of the
10496 initial biotransformation pathways for arylamine and heterocyclic amine
10500 display-str
"3q21.3-q25.2" ,
10502 map
-type cyto
} } ,
10507 gene
-display FALSE
,
10508 locus
-display FALSE
,
10509 extra
-terms FALSE
} ,
10513 heading
"Reference" ,
10514 accession
"NC_000003" ,
10526 heading
"Reference" ,
10527 accession
"NM_001086" ,
10560 gi
51511463 } } } ,
10567 heading
"Reference" ,
10568 accession
"NP_001077" ,
10601 gi
51511463 } } } ,
10614 value
"3.1.1.-" } } } } } } } } } ,
10617 heading
"Reference" ,
10618 accession
"NT_005612" ,
10630 heading
"Reference" ,
10631 accession
"NM_001086" ,
10664 gi
37550867 } } } ,
10671 heading
"Reference" ,
10672 accession
"NP_001077" ,
10705 gi
37550867 } } } ,
10718 value
"3.1.1.-" } } } } } } } } } ,
10721 heading
"Reference" ,
10722 accession
"NT_086641" ,
10734 heading
"Reference" ,
10735 accession
"NM_001086" ,
10768 gi
51464125 } } } ,
10775 heading
"Reference" ,
10776 accession
"NP_001077" ,
10809 gi
51464125 } } } ,
10822 value
"3.1.1.-" } } } } } } } } } } ,
10826 label
"Nomenclature" ,
10830 anchor
"HUGO Gene Nomenclature Committee" } } ,
10834 label
"Official Symbol" ,
10839 label
"Official Full Name" ,
10840 text
"arylacetamide deacetylase (esterase)" ,
10844 heading
"GeneOntology" ,
10848 pre
-text
"Provided by" ,
10850 url
"http://www.ebi.ac.uk/GOA/" } } ,
10868 anchor
"deacetylase activity" ,
10869 post
-text
"evidence: IDA" } } } } } ,
10884 anchor
"metabolism" ,
10885 post
-text
"evidence: IEA" } } } } } ,
10888 label
"Component" ,
10903 anchor
"endoplasmic reticulum membrane" ,
10904 post
-text
"evidence: IDA" } } } ,
10914 anchor
"integral to membrane" ,
10915 post
-text
"evidence: IEA" } } } ,
10927 anchor
"microsome" ,
10928 post
-text
"evidence: TAS" } } } } } } } } ,
10932 heading
"Mouse, Rat" ,
10940 anchor
"Map Viewer" ,
10941 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=3&M
10942 APS=genes-r-org/rat-chr/human%3A3,genes-r-org/mouse-chr/human%3A3,genes-r-org/
10943 human-chr3&query=e%3A13[id]+AND+gene[obj_type]&QSTR=aadac&cmd=focus&fill=10" } } } } ,
10947 heading
"LocusTagLink" ,
10957 heading
"RefSeq Status" ,
10973 heading
"Markers (Sequence Tagged Sites/STS)" ,
10985 anchor
"STS-L32179" ,
10986 post
-text
"(e-PCR)" } } ,
10990 label
"Alternate name" ,
10995 label
"Alternate name" ,
10996 text
"sts-L32179" ,
11008 post
-text
"(e-PCR)" } } ,
11012 label
"Alternate name" ,
11025 post
-text
"(e-PCR)" } } ,
11029 label
"Alternate name" ,
11041 anchor
"RH124029" ,
11042 post
-text
"(e-PCR)" } } ,
11046 label
"Alternate name" ,
11047 text
"SHGC-105511" ,
11048 version
0 } } } } } ,
11051 heading
"NCBI Reference Sequences (RefSeq)" ,
11056 heading
"mRNA Sequence" ,
11057 accession
"NM_001086" ,
11065 anchor
"NM_001086" } } ,
11072 heading
"Product" ,
11073 accession
"NP_001077" ,
11081 anchor
"NP_001077" ,
11082 post
-text
"arylacetamide deacetylase" } } ,
11089 heading
"Conserved Domains" ,
11098 anchor
"summary" } } ,
11109 anchor
"COG0657: Aes; Esterase/lipase [Lipid
11114 text
"Location: 33 - 399 Blast Score: 380" ,
11125 anchor
"cd00312: Esterase_lipase; Esterases and
11126 lipases (includes fungal lipases, cholinesterases, etc" } } ,
11130 text
"Location: 91 - 203 Blast Score: 144" ,
11131 version
0 } } } } } } } } ,
11135 heading
"Source Sequence" ,
11143 anchor
"L32179" } } ,
11147 version
0 } } } } } } } ,
11150 heading
"Related Sequences" ,
11156 accession
"BC020706" ,
11164 anchor
"BC020706" } } ,
11176 accession
"BC032309" ,
11184 anchor
"BC032309" } } ,
11191 accession
"AAH32309" ,
11199 anchor
"AAH32309" } } ,
11202 gi
21595551 } } } } ,
11206 accession
"L32179" ,
11214 anchor
"L32179" } } ,
11221 accession
"AAA35551" ,
11229 anchor
"AAA35551" } } ,
11232 gi
537514 } } } } ,
11240 accession
"P22760" ,
11248 anchor
"P22760" } } ,
11251 gi
57015294 } } } } } } ,
11254 heading
"Additional Links" ,
11263 db
"Evidence Viewer" ,
11266 anchor
"Evidence Viewer" ,
11267 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
11268 g=NT_005612.14&gene=AADAC&lid=13&from=58027020&to=58041428" } } } ,
11278 anchor
"ModelMaker" ,
11279 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
11280 06&contig=NT_005612.14&gene=AADAC&lid=13" } } } ,
11288 value
"Hs.506908" } } ,
11294 str
"Hs.506908" } ,
11295 anchor
"Hs.506908" ,
11296 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=50
11308 anchor
"600338" } } } ,
11318 anchor
"HomoloGene" ,
11319 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11320 13[loc]&TAXID=9606" } } } ,
11331 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
11332 ocusid&org=9606&l=13" } } } ,
11341 str
"GDB:392587" } } } } ,
11351 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=BC032
11362 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
11373 url
"http://www.genome.ad.jp/dbget-bin/www_bget?hsa:13" } } } ,
11384 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC032309" } } } } } ,
11387 heading
"Pathways" ,
11392 text
"KEGG pathway: Butanoate metabolism" ,
11401 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00650+13" } } } ,
11404 text
"KEGG pathway: Alkaloid biosynthesis II" ,
11413 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00960+13" } } } ,
11416 text
"KEGG pathway: 2,4-Dichlorobenzoate degradation" ,
11425 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00623+13" } } } ,
11428 text
"KEGG pathway: Pentose and glucuronate interconversions" ,
11437 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00040+13" } } } ,
11440 text
"KEGG pathway: Glycosylphosphatidylinositol(GPI)-anchor
11450 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00563+13" } } } } } } ,
11482 type protein
-coding
,
11487 taxname
"Homo sapiens" ,
11500 species
"sapiens" } ,
11501 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
11502 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
11509 subtype chromosome
,
11513 desc
"angio-associated, migratory cell protein" ,
11520 locus
-tag
"HGNC:18" } ,
11523 "angio-associated, migratory cell protein" } } ,
11524 summary
"The gene product is an immunoglobulin-type protein. It is found to
11525 be expressed strongly in endothelial cells, cytotrophoblasts, and poorly
11526 differentiated colon adenocarcinoma cells found in lymphatics. The protein
11527 contains a heparin-binding domain and mediates heparin-sensitive cell
11531 display-str
"2q35" ,
11533 map
-type cyto
} } ,
11538 gene
-display FALSE
,
11539 locus
-display FALSE
,
11540 extra
-terms FALSE
} ,
11544 heading
"Reference" ,
11545 accession
"NC_000002" ,
11557 heading
"Reference" ,
11558 accession
"NM_001087" ,
11627 gi
51511462 } } } ,
11634 heading
"Reference" ,
11635 accession
"NP_001078" ,
11704 gi
51511462 } } } ,
11707 gi
4557229 } } } } } } ,
11710 heading
"Reference" ,
11711 accession
"NT_005403" ,
11723 heading
"Reference" ,
11724 accession
"NM_001087" ,
11793 gi
51461028 } } } ,
11800 heading
"Reference" ,
11801 accession
"NP_001078" ,
11870 gi
51461028 } } } ,
11873 gi
4557229 } } } } } } ,
11876 heading
"Reference" ,
11877 accession
"NT_086634" ,
11889 heading
"Reference" ,
11890 accession
"NM_001087" ,
11959 gi
51463854 } } } ,
11966 heading
"Reference" ,
11967 accession
"NP_001078" ,
12036 gi
51463854 } } } ,
12039 gi
4557229 } } } } } } } ,
12043 label
"Nomenclature" ,
12047 anchor
"HUGO Gene Nomenclature Committee" } } ,
12051 label
"Official Symbol" ,
12056 label
"Official Full Name" ,
12057 text
"angio-associated, migratory cell protein" ,
12061 heading
"GeneOntology" ,
12065 pre
-text
"Provided by" ,
12067 url
"http://www.ebi.ac.uk/GOA/" } } ,
12085 anchor
"heparin binding" ,
12086 post
-text
"evidence: TAS" } } } } } ,
12101 anchor
"cell motility" ,
12102 post
-text
"evidence: NR" } } } } } } } } ,
12106 heading
"Mouse, Rat" ,
12114 anchor
"Map Viewer" ,
12115 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=2&M
12116 APS=genes-r-org/rat-chr/human%3A2,genes-r-org/mouse-chr/human%3A2,genes-r-org/
12117 human-chr2&query=e%3A14[id]+AND+gene[obj_type]&QSTR=aamp&cmd=focus&fill=10" } } } } ,
12121 heading
"LocusTagLink" ,
12131 heading
"RefSeq Status" ,
12145 heading
"Markers (Sequence Tagged Sites/STS)" ,
12157 anchor
"SGC31591" ,
12158 post
-text
"(e-PCR)" } } ,
12162 label
"Alternate name" ,
12167 label
"Alternate name" ,
12172 label
"Alternate name" ,
12177 label
"Alternate name" ,
12179 version
0 } } } } } ,
12182 heading
"NCBI Reference Sequences (RefSeq)" ,
12187 heading
"mRNA Sequence" ,
12188 accession
"NM_001087" ,
12196 anchor
"NM_001087" } } ,
12203 heading
"Product" ,
12204 accession
"NP_001078" ,
12212 anchor
"NP_001078" ,
12213 post
-text
"angio-associated, migratory cell protein" } } ,
12220 heading
"Conserved Domains" ,
12229 anchor
"summary" } } ,
12240 anchor
"cd00200: WD40; WD40 domain, found in a
12241 number of eukaryotic proteins that cover a wide variety of functions
12242 including adaptor/regulatory modules in signal transduction, pre-mRNA
12243 processing and cytoskeleton assembly" } } ,
12247 text
"Location: 86 - 386 Blast Score: 457" ,
12251 text
"Location: 325 - 430 Blast Score: 176" ,
12252 version
0 } } } } } } } } ,
12256 heading
"Source Sequence" ,
12263 str
"BG534787,CN277005,M95627" } ,
12264 anchor
"BG534787,CN277005,M95627" } } ,
12268 version
0 } } } } } } } ,
12271 heading
"Related Sequences" ,
12277 accession
"AB209790" ,
12285 anchor
"AB209790" } } ,
12292 accession
"BAD93027" ,
12300 anchor
"BAD93027" } } ,
12303 gi
62089166 } } } } ,
12307 accession
"AK131047" ,
12315 anchor
"AK131047" } } ,
12327 accession
"BC008809" ,
12335 anchor
"BC008809" } } ,
12342 accession
"AAH08809" ,
12350 anchor
"AAH08809" } } ,
12353 gi
39644832 } } } } ,
12357 accession
"BC014122" ,
12365 anchor
"BC014122" } } ,
12372 accession
"AAH14122" ,
12380 anchor
"AAH14122" } } ,
12383 gi
33874730 } } } } ,
12387 accession
"BC020244" ,
12395 anchor
"BC020244" } } ,
12402 accession
"AAH20244" ,
12410 anchor
"AAH20244" } } ,
12413 gi
18044384 } } } } ,
12417 accession
"BC039866" ,
12425 anchor
"BC039866" } } ,
12432 accession
"AAH39866" ,
12440 anchor
"AAH39866" } } ,
12443 gi
56200511 } } } } ,
12447 accession
"CR456755" ,
12455 anchor
"CR456755" } } ,
12462 accession
"CAG33036" ,
12470 anchor
"CAG33036" } } ,
12473 gi
48145627 } } } } ,
12477 accession
"M95627" ,
12485 anchor
"M95627" } } ,
12492 accession
"AAA68889" ,
12500 anchor
"AAA68889" } } ,
12503 gi
870803 } } } } ,
12511 accession
"Q13685" ,
12519 anchor
"Q13685" } } ,
12522 gi
3121739 } } } } } } ,
12525 heading
"Additional Links" ,
12534 db
"Evidence Viewer" ,
12537 anchor
"Evidence Viewer" ,
12538 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
12539 g=NT_005403.15&gene=AAMP&lid=14&from=69338268&to=69344275" } } } ,
12549 anchor
"ModelMaker" ,
12550 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
12551 06&contig=NT_005403.15&gene=AAMP&lid=14" } } } ,
12559 value
"Hs.83347" } } ,
12566 anchor
"Hs.83347" ,
12567 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=83
12579 anchor
"603488" } } } ,
12589 anchor
"HomoloGene" ,
12590 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
12591 14[loc]&TAXID=9606" } } } ,
12602 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
12603 ocusid&org=9606&l=14" } } } ,
12612 str
"GDB:4573993" } } } } ,
12622 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=AB209
12633 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
12645 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC014122" } } } } } } ,
12677 type protein
-coding
,
12682 taxname
"Homo sapiens" ,
12695 species
"sapiens" } ,
12696 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
12697 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
12704 subtype chromosome
,
12708 desc
"arylalkylamine N-acetyltransferase" ,
12718 locus
-tag
"HGNC:19" } ,
12721 "arylalkylamine N-acetyltransferase" ,
12722 "serotonin N-acetyltransferase" } } ,
12723 summary
"Arylalkylamine N-acetyltransferase belongs to the superfamily of
12724 acetyltransferases. It is the penultimate enzyme in melatonin synthesis and
12725 controls the night/day rhythm in melatonin production in the vertebrate
12726 pineal gland. Melatonin is essential for seasonal reproduction, modulates the
12727 function of the circadian clock in the suprachiasmatic nucleus, and
12728 influences activity and sleep. This enzyme is rapidly inactivated when
12729 animals are exposed to light at night. This protein is 80% identical to sheep
12730 and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a
12731 multifactorial genetic diseases such as altered behavior in sleep/wake cycle." ,
12734 display-str
"17q25" ,
12736 map
-type cyto
} } ,
12741 gene
-display FALSE
,
12742 locus
-display FALSE
,
12743 extra
-terms FALSE
} ,
12747 heading
"Reference" ,
12748 accession
"NC_000017" ,
12760 heading
"Reference" ,
12761 accession
"NM_001088" ,
12788 gi
51511734 } } } ,
12795 heading
"Reference" ,
12796 accession
"NP_001079" ,
12817 gi
51511734 } } } ,
12830 value
"2.3.1.87" } } } } } } } } } ,
12833 heading
"Reference" ,
12834 accession
"NT_010641" ,
12846 heading
"Reference" ,
12847 accession
"NM_001088" ,
12874 gi
51474120 } } } ,
12881 heading
"Reference" ,
12882 accession
"NP_001079" ,
12903 gi
51474120 } } } ,
12916 value
"2.3.1.87" } } } } } } } } } ,
12919 heading
"Reference" ,
12920 accession
"NT_086886" ,
12932 heading
"Reference" ,
12933 accession
"NM_001088" ,
12960 gi
51474508 } } } ,
12967 heading
"Reference" ,
12968 accession
"NP_001079" ,
12989 gi
51474508 } } } ,
13002 value
"2.3.1.87" } } } } } } } } } } ,
13006 label
"Nomenclature" ,
13010 anchor
"HUGO Gene Nomenclature Committee" } } ,
13014 label
"Official Symbol" ,
13019 label
"Official Full Name" ,
13020 text
"arylalkylamine N-acetyltransferase" ,
13024 heading
"GeneOntology" ,
13028 pre
-text
"Provided by" ,
13030 url
"http://www.ebi.ac.uk/GOA/" } } ,
13046 anchor
"acyltransferase activity" ,
13047 post
-text
"evidence: IEA" } } } ,
13059 anchor
"aralkylamine N-acetyltransferase activity" ,
13060 post
-text
"evidence: TAS" } } } ,
13070 anchor
"transferase activity" ,
13071 post
-text
"evidence: IEA" } } } } } ,
13088 anchor
"circadian rhythm" ,
13089 post
-text
"evidence: TAS" } } } } } } } } ,
13093 heading
"Mouse, Rat" ,
13101 anchor
"Map Viewer" ,
13102 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=17&
13103 MAPS=genes-r-org/rat-chr/human%3A17,genes-r-org/mouse-chr/human%3A17,genes-r-o
13104 rg/human-chr17&query=e%3A15[id]+AND+gene[obj_type]&QSTR=aanat&cmd=focus&fill=1
13109 heading
"LocusTagLink" ,
13119 heading
"RefSeq Status" ,
13141 heading
"NCBI Reference Sequences (RefSeq)" ,
13146 heading
"mRNA Sequence" ,
13147 accession
"NM_001088" ,
13155 anchor
"NM_001088" } } ,
13162 heading
"Product" ,
13163 accession
"NP_001079" ,
13171 anchor
"NP_001079" ,
13172 post
-text
"arylalkylamine N-acetyltransferase" } } ,
13179 heading
"Consensus CDS (CCDS)" ,
13186 str
"CCDS11745.1" } ,
13187 anchor
"CCDS11745.1" } } } ,
13190 heading
"Conserved Domains" ,
13199 anchor
"summary" } } ,
13210 anchor
"pfam00583: Acetyltransf_1; Acetyltransferase
13211 (GNAT) family" } } ,
13215 text
"Location: 82 - 174 Blast Score: 94" ,
13216 version
0 } } } } } } } } ,
13220 heading
"Source Sequence" ,
13228 anchor
"U40347" } } ,
13232 version
0 } } } } } } } ,
13235 heading
"Related Sequences" ,
13240 heading
"Genomic" ,
13241 accession
"AB023793" ,
13249 anchor
"AB023793" } } ,
13256 accession
"BAB20312" ,
13264 anchor
"BAB20312" } } ,
13267 gi
12248881 } } } } ,
13270 heading
"Genomic" ,
13271 accession
"AB023794" ,
13279 anchor
"AB023794" } } ,
13286 accession
"BAB20313" ,
13294 anchor
"BAB20313" } } ,
13297 gi
12248883 } } } } ,
13300 heading
"Genomic" ,
13301 accession
"AB023795" ,
13309 anchor
"AB023795" } } ,
13316 accession
"BAB20314" ,
13324 anchor
"BAB20314" } } ,
13327 gi
12248885 } } } } ,
13330 heading
"Genomic" ,
13331 accession
"AB023796" ,
13339 anchor
"AB023796" } } ,
13346 accession
"BAB20315" ,
13354 anchor
"BAB20315" } } ,
13357 gi
12248887 } } } } ,
13360 heading
"Genomic" ,
13361 accession
"AB023797" ,
13369 anchor
"AB023797" } } ,
13376 accession
"BAB20316" ,
13384 anchor
"BAB20316" } } ,
13387 gi
12248889 } } } } ,
13390 heading
"Genomic" ,
13391 accession
"AF360979" ,
13399 anchor
"AF360979" } } ,
13406 accession
"AAK49981" ,
13414 anchor
"AAK49981" } } ,
13417 gi
13936891 } } } } ,
13420 heading
"Genomic" ,
13421 accession
"U40391" ,
13429 anchor
"U40391" } } ,
13436 accession
"AAC50555" ,
13444 anchor
"AAC50555" } } ,
13447 gi
1389594 } } } } ,
13451 accession
"BC069434" ,
13459 anchor
"BC069434" } } ,
13466 accession
"AAH69434" ,
13474 anchor
"AAH69434" } } ,
13477 gi
46854804 } } } } ,
13481 accession
"U40347" ,
13489 anchor
"U40347" } } ,
13496 accession
"AAC50554" ,
13504 anchor
"AAC50554" } } ,
13507 gi
1389592 } } } } ,
13515 accession
"Q16613" ,
13523 anchor
"Q16613" } } ,
13526 gi
11387096 } } } } } } ,
13529 heading
"Additional Links" ,
13538 db
"Evidence Viewer" ,
13541 anchor
"Evidence Viewer" ,
13542 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
13543 g=NT_010641.15&gene=AANAT&lid=15&from=8389923&to=8392471" } } } ,
13553 anchor
"ModelMaker" ,
13554 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
13555 06&contig=NT_010641.15&gene=AANAT&lid=15" } } } ,
13563 value
"Hs.431417" } } ,
13569 str
"Hs.431417" } ,
13570 anchor
"Hs.431417" ,
13571 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=43
13583 anchor
"600950" } } } ,
13593 anchor
"HomoloGene" ,
13594 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
13595 15[loc]&TAXID=9606" } } } ,
13606 url
"http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
13607 ocusid&org=9606&l=15" } } } ,
13616 str
"GDB:700076" } } } } ,
13626 url
"http://www.ensembl.org/Homo_sapiens/contigview?geneid=U4034
13637 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
13648 url
"http://www.genome.ad.jp/dbget-bin/www_bget?hsa:15" } } } ,
13659 anchor
"PA24366" } } } ,
13670 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC069434" } } } } } ,
13673 heading
"Pathways" ,
13678 text
"KEGG pathway: Tryptophan metabolism" ,
13687 url
"http://www.genome.jp/dbget-bin/show_pathway?hsa00380+15" } } } } } ,
13690 text
"Data suggest that the -263G/C single nucleotide polymorphism of
13691 arylalkylamine-N-acetyl-transferase (AA-NAT) may be an important determinant
13692 of the late/short sleep pattern." ,
13697 str
"Sep 27 2004 4:34PM" ,
13699 str
"Sep 27 2004 7:00PM" } ,
13702 text
"There is a significant increase in AANAT allele positivity at the
13703 single nucleotide polymorphism (alanine 129--> threonine) at between patients
13704 with DSPS & controls. AA-NAT could be a susceptibility gene for DSPS." ,
13709 str
"Jul 10 2003 12:00AM" ,
13711 str
"May 30 2004 7:11AM" } } ,
13752 type protein
-coding
,
13757 taxname
"Mus musculus" ,
13758 common
"house mouse" ,
13770 species
"musculus" } ,
13771 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
13772 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
13773 Sciurognathi; Muridae; Murinae; Mus" ,
13783 gene
-display FALSE
,
13784 locus
-display FALSE
,
13785 extra
-terms FALSE
} ,
13831 taxname
"Mus musculus" ,
13832 common
"house mouse" ,
13844 species
"musculus" } ,
13845 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
13846 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
13847 Sciurognathi; Muridae; Murinae; Mus" ,
13857 gene
-display FALSE
,
13858 locus
-display FALSE
,
13859 extra
-terms FALSE
} ,
13868 text
"phenotype only" ,
13880 value
"phenotype only" } } }
13901 type protein
-coding
,
13906 taxname
"Mus musculus" ,
13907 common
"house mouse" ,
13919 species
"musculus" } ,
13920 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
13921 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
13922 Sciurognathi; Muridae; Murinae; Mus" ,
13928 subtype chromosome
,
13932 desc
"pregnancy zone protein" ,
13933 maploc
"6 62.0 cM" ,
13938 locus
-tag
"MGI:87854" } ,
13941 "pregnancy zone protein" ,
13942 "alpha 1 macroglobulin" } } ,
13945 display-str
"6 F1-G3" ,
13949 display-str
"6 62.0 cM" ,
13956 gene
-display FALSE
,
13957 locus
-display FALSE
,
13958 extra
-terms FALSE
} ,
13962 heading
"Reference" ,
13963 accession
"NC_000072" ,
13975 heading
"Reference" ,
13976 accession
"NM_007376" ,
14195 gi
51863714 } } } ,
14202 heading
"Reference" ,
14203 accession
"NP_031402" ,
14422 gi
51863714 } } } ,
14425 gi
6680608 } } } } } } ,
14428 heading
"Reference" ,
14429 accession
"NT_039356" ,
14441 heading
"Reference" ,
14442 accession
"NM_007376" ,
14661 gi
51712708 } } } ,
14668 heading
"Reference" ,
14669 accession
"NP_031402" ,
14888 gi
51712708 } } } ,
14891 gi
6680608 } } } } } } } ,
14895 label
"Nomenclature" ,
14899 anchor
"Mouse Genome Informatics" } } ,
14903 label
"Official Symbol" ,
14908 label
"Official Full Name" ,
14909 text
"pregnancy zone protein" ,
14913 heading
"GeneOntology" ,
14917 pre
-text
"Provided by" ,
14919 url
"http://www.informatics.jax.org/" } } ,
14937 anchor
"endopeptidase inhibitor activity" ,
14938 post
-text
"evidence: IDA" } } } ,
14948 anchor
"serine-type endopeptidase inhibitor activity" ,
14949 post
-text
"evidence: IEA" } } } ,
14959 anchor
"wide-spectrum protease inhibitor activity" ,
14960 post
-text
"evidence: IEA" } } } } } ,
14963 label
"Component" ,
14977 anchor
"extracellular region" ,
14978 post
-text
"evidence: TAS" } } } ,
14990 anchor
"extracellular space" ,
14991 post
-text
"evidence: TAS" } } } } } } } } ,
15003 anchor
"Map Viewer" ,
15004 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=6&
15005 MAPS=genes-r-org/rat-chr/mouse%3A6,genes-r-org/mouse-chr6&query=e%3A11287[id]+
15006 AND+gene[obj_type]&QSTR=pzp&cmd=focus&fill=10" } } } } ,
15010 heading
"LocusTagLink" ,
15020 heading
"RefSeq Status" ,
15021 label
"PROVISIONAL" ,
15034 heading
"Markers (Sequence Tagged Sites/STS)" ,
15047 post
-text
"(e-PCR)" } } ,
15051 label
"Alternate name" ,
15056 label
"Alternate name" ,
15057 text
"MGI:893149" ,
15061 label
"Alternate name" ,
15073 anchor
"AI838740" ,
15074 post
-text
"(e-PCR)" } } ,
15078 label
"Alternate name" ,
15090 anchor
"AI893533" ,
15091 post
-text
"(e-PCR)" } } ,
15095 label
"Alternate name" ,
15097 version
0 } } } } } ,
15100 heading
"NCBI Reference Sequences (RefSeq)" ,
15105 heading
"mRNA Sequence" ,
15106 accession
"NM_007376" ,
15114 anchor
"NM_007376" } } ,
15121 heading
"Product" ,
15122 accession
"NP_031402" ,
15130 anchor
"NP_031402" ,
15131 post
-text
"pregnancy zone protein" } } ,
15138 heading
"Conserved Domains" ,
15147 anchor
"summary" } } ,
15158 anchor
"pfam00207: A2M; Alpha-2-macroglobulin family" } } ,
15162 text
"Location: 738 - 1482 Blast Score: 1820" ,
15173 anchor
"pfam01835: A2M_N; Alpha-2-macroglobulin
15174 family N-terminal region" } } ,
15178 text
"Location: 22 - 622 Blast Score: 1231" ,
15179 version
0 } } } } } } } } ,
15183 heading
"Source Sequence" ,
15191 anchor
"M93264" } } ,
15195 version
0 } } } } } } } ,
15198 heading
"Related Sequences" ,
15203 heading
"Genomic" ,
15204 accession
"U06977" ,
15212 anchor
"U06977" } } ,
15219 accession
"AAA87890" ,
15227 anchor
"AAA87890" } } ,
15230 gi
463884 } } } } ,
15234 accession
"BC057983" ,
15242 anchor
"BC057983" } } ,
15249 accession
"AAH57983" ,
15257 anchor
"AAH57983" } } ,
15260 gi
34785996 } } } ,
15270 accession
"M93264" ,
15278 anchor
"M93264" } } ,
15285 accession
"AAA39508" ,
15293 anchor
"AAA39508" } } ,
15296 gi
199086 } } } } ,
15304 accession
"Q61838" ,
15312 anchor
"Q61838" } } ,
15315 gi
2492496 } } } } } } ,
15318 heading
"Additional Links" ,
15327 db
"Evidence Viewer" ,
15330 anchor
"Evidence Viewer" ,
15331 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
15332 ig=NT_039356.3&gene=Pzp&lid=11287&from=3999238&to=4042377" } } } ,
15342 anchor
"ModelMaker" ,
15343 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
15344 090&contig=NT_039356.3&gene=Pzp&lid=11287" } } } ,
15352 value
"Mm.260144" } } ,
15358 str
"Mm.260144" } ,
15359 anchor
"Mm.260144" ,
15360 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=26
15371 anchor
"HomoloGene" ,
15372 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
15373 11287[loc]&TAXID=10090" } } } ,
15384 url
"http://www.informatics.jax.org/searches/accession_report.cg
15385 i?id=MGI:87854" } } } ,
15395 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=BC057
15406 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
15410 text
"Gene Expression Database (GXD) at MGI" ,
15415 db
"Gene Expression Database (GXD) at MGI" ,
15417 str
"MGI:87854" } ,
15418 anchor
"MGI:87854" ,
15419 url
"http://www.informatics.jax.org/searches/expression_report.c
15420 gi?id=MGI:87854" } } } ,
15431 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Mm&LIST=BC057983" } } } } } ,
15434 heading
"Alleles" ,
15439 text
"The following allele types are documented at Mouse Genome
15445 url
"http://www.informatics.jax.org/searches/allele_report.cgi?m
15446 arkerID=MGI:87854" } } } ,
15449 heading
"Targeted (knock-out) (1)" ,
15452 pmid
7544347 } } } } } ,
15498 taxname
"Mus musculus" ,
15499 common
"house mouse" ,
15511 species
"musculus" } ,
15512 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15513 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15514 Sciurognathi; Muridae; Murinae; Mus" ,
15524 gene
-display FALSE
,
15525 locus
-display FALSE
,
15526 extra
-terms FALSE
} ,
15535 text
"phenotype only" ,
15547 value
"phenotype only" } } }
15577 type protein
-coding
,
15582 taxname
"Mus musculus" ,
15583 common
"house mouse" ,
15595 species
"musculus" } ,
15596 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15597 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15598 Sciurognathi; Muridae; Murinae; Mus" ,
15608 gene
-display FALSE
,
15609 locus
-display FALSE
,
15610 extra
-terms FALSE
} ,
15656 taxname
"Mus musculus" ,
15657 common
"house mouse" ,
15669 species
"musculus" } ,
15670 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15671 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15672 Sciurognathi; Muridae; Murinae; Mus" ,
15682 gene
-display FALSE
,
15683 locus
-display FALSE
,
15684 extra
-terms FALSE
} ,
15693 text
"phenotype only" ,
15705 value
"phenotype only" } } }
15740 taxname
"Mus musculus" ,
15741 common
"house mouse" ,
15753 species
"musculus" } ,
15754 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15755 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15756 Sciurognathi; Muridae; Murinae; Mus" ,
15766 gene
-display FALSE
,
15767 locus
-display FALSE
,
15768 extra
-terms FALSE
} ,
15777 text
"phenotype only" ,
15789 value
"phenotype only" } } }
15824 taxname
"Mus musculus" ,
15825 common
"house mouse" ,
15837 species
"musculus" } ,
15838 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15839 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15840 Sciurognathi; Muridae; Murinae; Mus" ,
15850 gene
-display FALSE
,
15851 locus
-display FALSE
,
15852 extra
-terms FALSE
} ,
15861 text
"phenotype only" ,
15873 value
"phenotype only" } } }
15903 type protein
-coding
,
15908 taxname
"Mus musculus" ,
15909 common
"house mouse" ,
15921 species
"musculus" } ,
15922 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15923 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15924 Sciurognathi; Muridae; Murinae; Mus" ,
15934 gene
-display FALSE
,
15935 locus
-display FALSE
,
15936 extra
-terms FALSE
} ,
15977 type protein
-coding
,
15982 taxname
"Mus musculus" ,
15983 common
"house mouse" ,
15995 species
"musculus" } ,
15996 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
15997 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
15998 Sciurognathi; Muridae; Murinae; Mus" ,
16008 gene
-display FALSE
,
16009 locus
-display FALSE
,
16010 extra
-terms FALSE
} ,
16042 type protein
-coding
,
16047 taxname
"Mus musculus" ,
16048 common
"house mouse" ,
16060 species
"musculus" } ,
16061 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
16062 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
16063 Sciurognathi; Muridae; Murinae; Mus" ,
16069 subtype chromosome
,
16073 desc
"arylalkylamine N-acetyltransferase" ,
16074 maploc
"11 70.0 cM" ,
16079 locus
-tag
"MGI:1328365" } ,
16082 "arylalkylamine N-acetyltransferase" } } ,
16085 display-str
"11 E2" ,
16089 display-str
"11 70.0 cM" ,
16096 gene
-display FALSE
,
16097 locus
-display FALSE
,
16098 extra
-terms FALSE
} ,
16102 heading
"Reference" ,
16103 accession
"NC_000077" ,
16115 heading
"Reference" ,
16116 accession
"NM_009591" ,
16143 gi
51868608 } } } ,
16150 heading
"Reference" ,
16151 accession
"NP_033721" ,
16172 gi
51868608 } } } ,
16175 gi
6752938 } } } } } } ,
16178 heading
"Reference" ,
16179 accession
"NT_039521" ,
16191 heading
"Reference" ,
16192 accession
"NM_009591" ,
16219 gi
51766637 } } } ,
16226 heading
"Reference" ,
16227 accession
"NP_033721" ,
16248 gi
51766637 } } } ,
16251 gi
6752938 } } } } } } } ,
16255 label
"Nomenclature" ,
16259 anchor
"Mouse Genome Informatics" } } ,
16263 label
"Official Symbol" ,
16268 label
"Official Full Name" ,
16269 text
"arylalkylamine N-acetyltransferase" ,
16273 heading
"GeneOntology" ,
16277 pre
-text
"Provided by" ,
16279 url
"http://www.informatics.jax.org/" } } ,
16295 anchor
"N-acetyltransferase activity" ,
16296 post
-text
"evidence: IEA" } } } ,
16306 anchor
"acyltransferase activity" ,
16307 post
-text
"evidence: IEA" } } } ,
16317 anchor
"arylamine N-acetyltransferase activity" ,
16318 post
-text
"evidence: IEA" } } } ,
16328 anchor
"transferase activity" ,
16329 post
-text
"evidence: IEA" } } } } } } } } ,
16333 heading
"Human, Rat" ,
16341 anchor
"Map Viewer" ,
16342 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=11
16343 &MAPS=genes-r-org/human-chr/mouse%3A11,genes-r-org/rat-chr/mouse%3A11,genes-r-
16344 org/mouse-chr11&query=e%3A11298[id]+AND+gene[obj_type]&QSTR=aanat&cmd=focus&fi
16349 heading
"LocusTagLink" ,
16356 id
1328365 } } } } ,
16359 heading
"RefSeq Status" ,
16360 label
"PROVISIONAL" ,
16371 heading
"Markers (Sequence Tagged Sites/STS)" ,
16383 anchor
"D11Mit102" ,
16384 post
-text
"(e-PCR)" } } ,
16388 label
"Alternate name" ,
16389 text
"MGI:707739" ,
16393 label
"Alternate name" ,
16395 version
0 } } } } } ,
16398 heading
"NCBI Reference Sequences (RefSeq)" ,
16403 heading
"mRNA Sequence" ,
16404 accession
"NM_009591" ,
16412 anchor
"NM_009591" } } ,
16419 heading
"Product" ,
16420 accession
"NP_033721" ,
16428 anchor
"NP_033721" ,
16429 post
-text
"arylalkylamine N-acetyltransferase" } } ,
16436 heading
"Conserved Domains" ,
16445 anchor
"summary" } } ,
16456 anchor
"pfam00583: Acetyltransf_1; Acetyltransferase
16457 (GNAT) family" } } ,
16461 text
"Location: 80 - 172 Blast Score: 118" ,
16462 version
0 } } } } } } } } ,
16466 heading
"Source Sequence" ,
16474 anchor
"AF004108" } } ,
16478 version
0 } } } } } } } ,
16481 heading
"Related Sequences" ,
16486 heading
"Genomic" ,
16487 accession
"U83462" ,
16495 anchor
"U83462" } } ,
16502 accession
"AAD08637" ,
16510 anchor
"AAD08637" } } ,
16523 accession
"AB013358" ,
16531 anchor
"AB013358" } } ,
16538 accession
"BAA31526" ,
16546 anchor
"BAA31526" } } ,
16559 accession
"AF004108" ,
16567 anchor
"AF004108" } } ,
16574 accession
"AAD09408" ,
16582 anchor
"AAD09408" } } ,
16595 accession
"AF004109" ,
16603 anchor
"AF004109" } } ,
16610 accession
"AAD09409" ,
16618 anchor
"AAD09409" } } ,
16631 accession
"AF004110" ,
16639 anchor
"AF004110" } } ,
16646 accession
"AAD09410" ,
16654 anchor
"AAD09410" } } ,
16667 accession
"AF004111" ,
16675 anchor
"AF004111" } } ,
16682 accession
"AAD09411" ,
16690 anchor
"AAD09411" } } ,
16707 accession
"O88816" ,
16715 anchor
"O88816" } } ,
16718 gi
11387071 } } } } } } ,
16721 heading
"Additional Links" ,
16730 db
"Evidence Viewer" ,
16733 anchor
"Evidence Viewer" ,
16734 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
16735 ig=NT_039521.3&gene=Aanat&lid=11298&from=27994170&to=27998027" } } } ,
16745 anchor
"ModelMaker" ,
16746 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
16747 090&contig=NT_039521.3&gene=Aanat&lid=11298" } } } ,
16755 value
"Mm.42233" } } ,
16762 anchor
"Mm.42233" ,
16763 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=42
16774 anchor
"HomoloGene" ,
16775 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
16776 11298[loc]&TAXID=10090" } } } ,
16787 url
"http://www.informatics.jax.org/searches/accession_report.cg
16788 i?id=MGI:1328365" } } } ,
16798 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=AF004
16809 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
16810 AF004110" } } } } } ,
16813 text
"AANAT expression and synthesis of N-acetylserotonin/melatonin
16814 could play a role in addictive properties of cocaine" ,
16819 str
"Aug 19 2002 12:00AM" ,
16821 str
"Aug 28 2002 6:19PM" } } ,
16867 taxname
"Mus musculus" ,
16868 common
"house mouse" ,
16880 species
"musculus" } ,
16881 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
16882 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
16883 Sciurognathi; Muridae; Murinae; Mus" ,
16893 gene
-display FALSE
,
16894 locus
-display FALSE
,
16895 extra
-terms FALSE
} ,
16904 text
"phenotype only" ,
16916 value
"phenotype only" } } }
16951 taxname
"Mus musculus" ,
16952 common
"house mouse" ,
16964 species
"musculus" } ,
16965 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
16966 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
16967 Sciurognathi; Muridae; Murinae; Mus" ,
16977 gene
-display FALSE
,
16978 locus
-display FALSE
,
16979 extra
-terms FALSE
} ,
16988 text
"phenotype only" ,
17000 value
"phenotype only" } } }
17030 type protein
-coding
,
17035 taxname
"Mus musculus" ,
17036 common
"house mouse" ,
17048 species
"musculus" } ,
17049 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
17050 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
17051 Sciurognathi; Muridae; Murinae; Mus" ,
17061 gene
-display FALSE
,
17062 locus
-display FALSE
,
17063 extra
-terms FALSE
} ,
17095 type protein
-coding
,
17100 taxname
"Mus musculus" ,
17101 common
"house mouse" ,
17113 species
"musculus" } ,
17114 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
17115 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
17116 Sciurognathi; Muridae; Murinae; Mus" ,
17122 subtype chromosome
,
17126 desc
"apoptosis-associated tyrosine kinase" ,
17131 locus
-tag
"MGI:1197518" } ,
17134 "apoptosis-associated tyrosine kinase" } } ,
17137 display-str
"11 E2" ,
17139 map
-type cyto
} } ,
17144 gene
-display FALSE
,
17145 locus
-display FALSE
,
17146 extra
-terms FALSE
} ,
17150 heading
"Reference" ,
17151 accession
"NC_000077" ,
17163 heading
"Reference" ,
17164 accession
"NM_007377" ,
17245 gi
51868608 } } } ,
17252 heading
"Reference" ,
17253 accession
"NP_031403" ,
17334 gi
51868608 } } } ,
17337 gi
6680610 } } } } } } ,
17340 heading
"Reference" ,
17341 accession
"NT_039521" ,
17353 heading
"Reference" ,
17354 accession
"NM_007377" ,
17435 gi
51766637 } } } ,
17442 heading
"Reference" ,
17443 accession
"NP_031403" ,
17524 gi
51766637 } } } ,
17527 gi
6680610 } } } } } } } ,
17531 label
"Nomenclature" ,
17535 anchor
"Mouse Genome Informatics" } } ,
17539 label
"Official Symbol" ,
17544 label
"Official Full Name" ,
17545 text
"apoptosis-associated tyrosine kinase" ,
17549 heading
"GeneOntology" ,
17553 pre
-text
"Provided by" ,
17555 url
"http://www.informatics.jax.org/" } } ,
17571 anchor
"ATP binding" ,
17572 post
-text
"evidence: IEA" } } } ,
17582 anchor
"kinase activity" ,
17583 post
-text
"evidence: IEA" } } } ,
17595 anchor
"protein kinase activity" ,
17596 post
-text
"evidence: ISS" } } } ,
17608 anchor
"protein serine/threonine kinase activity" ,
17609 post
-text
"evidence: ISS" } } } ,
17621 anchor
"protein-tyrosine kinase activity" ,
17622 post
-text
"evidence: ISS" } } } ,
17632 anchor
"transferase activity" ,
17633 post
-text
"evidence: IEA" } } } } } ,
17650 anchor
"apoptosis" ,
17651 post
-text
"evidence: IDA" } } } ,
17663 anchor
"protein amino acid phosphorylation" ,
17664 post
-text
"evidence: ISS" } } } } } } } } ,
17676 anchor
"Map Viewer" ,
17677 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=11
17678 &MAPS=genes-r-org/rat-chr/mouse%3A11,genes-r-org/mouse-chr11&query=e%3A11302[i
17679 d]+AND+gene[obj_type]&QSTR=aatk&cmd=focus&fill=10" } } } } ,
17683 heading
"LocusTagLink" ,
17690 id
1197518 } } } } ,
17693 heading
"RefSeq Status" ,
17694 label
"PROVISIONAL" ,
17711 heading
"NCBI Reference Sequences (RefSeq)" ,
17716 heading
"mRNA Sequence" ,
17717 accession
"NM_007377" ,
17725 anchor
"NM_007377" } } ,
17732 heading
"Product" ,
17733 accession
"NP_031403" ,
17741 anchor
"NP_031403" ,
17742 post
-text
"apoptosis-associated tyrosine kinase" } } ,
17749 heading
"Conserved Domains" ,
17758 anchor
"summary" } } ,
17769 anchor
"cd00192: TyrKc; Tyrosine kinase, catalytic
17774 text
"Location: 75 - 348 Blast Score: 588" ,
17775 version
0 } } } } } } } } ,
17779 heading
"Source Sequence" ,
17787 anchor
"BC080846" } } ,
17791 version
0 } } } } } } } ,
17794 heading
"Related Sequences" ,
17800 accession
"AB093253" ,
17808 anchor
"AB093253" } } ,
17815 accession
"BAC41437" ,
17823 anchor
"BAC41437" } } ,
17826 gi
39104555 } } } } ,
17830 accession
"AF011908" ,
17838 anchor
"AF011908" } } ,
17845 accession
"AAB71837" ,
17853 anchor
"AAB71837" } } ,
17856 gi
2459993 } } } } ,
17860 accession
"AK036705" ,
17868 anchor
"AK036705" } } ,
17875 accession
"BAC29541" ,
17883 anchor
"BAC29541" } } ,
17886 gi
26331622 } } } ,
17896 accession
"AK076214" ,
17904 anchor
"AK076214" } } ,
17922 accession
"AY236858" ,
17930 anchor
"AY236858" } } ,
17937 accession
"AAO92350" ,
17945 anchor
"AAO92350" } } ,
17948 gi
29824956 } } } } ,
17952 accession
"AY236859" ,
17960 anchor
"AY236859" } } ,
17967 accession
"AAO92351" ,
17975 anchor
"AAO92351" } } ,
17978 gi
29824958 } } } ,
17988 accession
"BC042837" ,
17996 anchor
"BC042837" } } ,
18008 accession
"BC052323" ,
18016 anchor
"BC052323" } } ,
18028 accession
"BC080846" ,
18036 anchor
"BC080846" } } ,
18043 accession
"AAH80846" ,
18051 anchor
"AAH80846" } } ,
18054 gi
51593714 } } } ,
18060 version
0 } } } } } ,
18063 heading
"Additional Links" ,
18072 db
"Evidence Viewer" ,
18075 anchor
"Evidence Viewer" ,
18076 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
18077 ig=NT_039521.3&gene=Aatk&lid=11302&from=31407804&to=31422032" } } } ,
18087 anchor
"ModelMaker" ,
18088 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
18089 090&contig=NT_039521.3&gene=Aatk&lid=11302" } } } ,
18097 value
"Mm.6826" } } ,
18105 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=68
18116 anchor
"HomoloGene" ,
18117 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
18118 11302[loc]&TAXID=10090" } } } ,
18129 url
"http://www.informatics.jax.org/searches/accession_report.cg
18130 i?id=MGI:1197518" } } } ,
18140 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=BC052
18151 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
18163 url
"http://mgc.nci.nih.gov/Genes/CloneList?ORG=Mm&LIST=BC080846" } } } } } ,
18166 text
"Expression of AATYK mRNA and protein increased during postnatal
18167 brain development. In immature granule cells, overexpression of AATYK
18168 promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly
18174 str
"Jun 17 2003 12:00AM" ,
18176 str
"Aug 3 2003 7:06AM" } } ,
18208 type protein
-coding
,
18213 taxname
"Mus musculus" ,
18214 common
"house mouse" ,
18226 species
"musculus" } ,
18227 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
18228 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
18229 Sciurognathi; Muridae; Murinae; Mus" ,
18235 subtype chromosome
,
18239 desc
"ATP-binding cassette, sub-family A (ABC1), member 1" ,
18240 maploc
"4 23.1 cM" ,
18243 locus
-tag
"MGI:99607" } ,
18246 "ATP-binding cassette 1, sub-family A, member 1" ,
18247 "ATP-binding cassette 1" } } ,
18248 summary
"The membrane-associated protein encoded by this gene is a member of
18249 the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins
18250 transport various molecules across extra- and intracellular membranes. ABC
18251 genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD,
18252 OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members
18253 of the ABC1 subfamily comprise the only major ABC subfamily found exclusively
18254 in multicellular eukaryotes. In humans, this protein functions as a
18255 cholesterol efflux pump in the cellular lipid removal pathway. Mutations in
18256 the human gene have been associated with Tangier's disease and familial
18257 high-density lipoprotein deficiency." ,
18260 display-str
"4 A5-B3" ,
18264 display-str
"4 23.1 cM" ,
18271 gene
-display FALSE
,
18272 locus
-display FALSE
,
18273 extra
-terms FALSE
} ,
18277 heading
"Reference" ,
18278 accession
"NC_000070" ,
18290 heading
"Reference" ,
18291 accession
"NM_013454" ,
18594 gi
51860768 } } } ,
18601 heading
"Reference" ,
18602 accession
"NP_038482" ,
18899 gi
51860768 } } } ,
18902 gi
34577069 } } } } } } ,
18905 heading
"Reference" ,
18906 accession
"NT_039260" ,
18918 heading
"Reference" ,
18919 accession
"NM_013454" ,
19222 gi
51709342 } } } ,
19229 heading
"Reference" ,
19230 accession
"NP_038482" ,
19527 gi
51709342 } } } ,
19530 gi
34577069 } } } } } } } ,
19534 label
"Nomenclature" ,
19538 anchor
"Mouse Genome Informatics" } } ,
19542 label
"Official Symbol" ,
19547 label
"Official Full Name" ,
19548 text
"ATP-binding cassette, sub-family A (ABC1), member 1" ,
19552 heading
"GeneOntology" ,
19556 pre
-text
"Provided by" ,
19558 url
"http://www.informatics.jax.org/" } } ,
19574 anchor
"ATP binding" ,
19575 post
-text
"evidence: IEA" } } } ,
19585 anchor
"ATPase activity" ,
19586 post
-text
"evidence: IEA" } } } } } ,
19603 anchor
"cholesterol metabolism" ,
19604 post
-text
"evidence: IDA" } } } ,
19616 anchor
"cholesterol transport" ,
19617 post
-text
"evidence: IDA" } } } ,
19629 anchor
"lipoprotein biosynthesis" ,
19630 post
-text
"evidence: IMP" } } } ,
19642 anchor
"phagocytosis, engulfment" ,
19643 post
-text
"evidence: IMP" } } } ,
19655 anchor
"phospholipid translocation" ,
19656 post
-text
"evidence: IMP" } } } ,
19666 anchor
"transport" ,
19667 post
-text
"evidence: IEA" } } } } } ,
19670 label
"Component" ,
19684 anchor
"Golgi apparatus" ,
19685 post
-text
"evidence: IDA" } } } ,
19697 anchor
"integral to membrane" ,
19698 post
-text
"evidence: TAS" } } } ,
19710 anchor
"integral to plasma membrane" ,
19711 post
-text
"evidence: IDA" } } } ,
19723 anchor
"intracellular membrane-bound organelle" ,
19724 post
-text
"evidence: IDA" } } } } } } } } ,
19728 heading
"Human, Rat" ,
19736 anchor
"Map Viewer" ,
19737 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=4&
19738 MAPS=genes-r-org/human-chr/mouse%3A4,genes-r-org/rat-chr/mouse%3A4,genes-r-org
19739 /mouse-chr4&query=e%3A11303[id]+AND+gene[obj_type]&QSTR=abca1&cmd=focus&fill=1
19744 heading
"LocusTagLink" ,
19754 heading
"RefSeq Status" ,
19817 heading
"Markers (Sequence Tagged Sites/STS)" ,
19830 post
-text
"(e-PCR)" } } ,
19834 label
"Alternate name" ,
19839 label
"Alternate name" ,
19851 anchor
"PMC16657P1" ,
19852 post
-text
"(e-PCR)" } } } ,
19862 anchor
"PMC207565P1" ,
19863 post
-text
"(e-PCR)" } } } } } ,
19866 heading
"NCBI Reference Sequences (RefSeq)" ,
19871 heading
"mRNA Sequence" ,
19872 accession
"NM_013454" ,
19880 anchor
"NM_013454" } } ,
19887 heading
"Product" ,
19888 accession
"NP_038482" ,
19896 anchor
"NP_038482" ,
19897 post
-text
"ATP-binding cassette 1, sub-family A, member 1" } } ,
19904 heading
"Conserved Domains" ,
19913 anchor
"summary" } } ,
19924 anchor
"cd00267: ABC_ATPase; ABC (ATP-binding
19925 cassette) transporter nucleotide-binding domain" } } ,
19929 text
"Location: 899 - 1114 Blast Score: 462" ,
19933 text
"Location: 1912 - 2121 Blast Score: 356" ,
19944 anchor
"COG4152: COG4152; ABC-type uncharacterized
19945 transport system, ATPase component [General function prediction only]" } } ,
19949 text
"Location: 1912 - 2218 Blast Score: 360" ,
19950 version
0 } } } } } } } } ,
19954 heading
"Source Sequence" ,
19961 str
"AK045442,BB657864,CA885568,X75926" } ,
19962 anchor
"AK045442,BB657864,CA885568,X75926" } } ,
19966 version
0 } } } } } } } ,
19969 heading
"Related Sequences" ,
19974 heading
"Genomic" ,
19975 accession
"AF287263" ,
19983 anchor
"AF287263" } } ,
19990 accession
"AAG39073" ,
19998 anchor
"AAG39073" } } ,
20001 gi
11611825 } } } ,
20011 accession
"AK019548" ,
20019 anchor
"AK019548" } } ,
20037 accession
"AK045442" ,
20045 anchor
"AK045442" } } ,
20063 accession
"AK051920" ,
20071 anchor
"AK051920" } } ,
20078 accession
"BAC34811" ,
20086 anchor
"BAC34811" } } ,
20089 gi
26342298 } } } ,
20099 accession
"BB657864" ,
20107 anchor
"BB657864" } } ,
20119 accession
"CA885568" ,
20127 anchor
"CA885568" } } ,
20145 accession
"X75926" ,
20153 anchor
"X75926" } } ,
20160 accession
"CAA53530" ,
20168 anchor
"CAA53530" } } ,
20185 accession
"P41233" ,
20193 anchor
"P41233" } } ,
20196 gi
51338775 } } } } } } ,
20199 heading
"Additional Links" ,
20208 db
"Evidence Viewer" ,
20211 anchor
"Evidence Viewer" ,
20212 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
20213 ig=NT_039260.3&gene=Abca1&lid=11303&from=26554541&to=26683645" } } } ,
20223 anchor
"ModelMaker" ,
20224 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
20225 090&contig=NT_039260.3&gene=Abca1&lid=11303" } } } ,
20233 value
"Mm.277376" } } ,
20239 str
"Mm.277376" } ,
20240 anchor
"Mm.277376" ,
20241 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=27
20252 anchor
"HomoloGene" ,
20253 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
20254 11303[loc]&TAXID=10090" } } } ,
20265 url
"http://www.informatics.jax.org/searches/accession_report.cg
20266 i?id=MGI:99607" } } } ,
20276 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=X7592
20287 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
20291 text
"Gene Expression Database (GXD) at MGI" ,
20296 db
"Gene Expression Database (GXD) at MGI" ,
20298 str
"MGI:99607" } ,
20299 anchor
"MGI:99607" ,
20300 url
"http://www.informatics.jax.org/searches/expression_report.c
20301 gi?id=MGI:99607" } } } ,
20304 text
"Human ABC-Transporter Proteins" ,
20309 db
"Human ABC-Transporter Proteins" ,
20311 str
"Human ABC-Transporter Proteins" } ,
20312 anchor
"Human ABC-Transporter Proteins" ,
20313 url
"http://nutrigene.4t.com/humanabc.htm" } } } } } ,
20316 text
"Gene deletion protects aginst cerebral malaria from Plasmodium
20322 str
"Mar 7 2005 7:07PM" ,
20324 str
"Mar 8 2005 3:26AM" } ,
20327 text
"ABCA1-dependent cholesterol mobilization to apoA-I increased new
20328 cholesterol synthesis, indicating depletion of the regulatory pool of
20329 hepatocyte cholesterol during HDL formation" ,
20334 str
"Mar 7 2005 7:07PM" ,
20336 str
"Mar 8 2005 12:40AM" } ,
20339 text
"a 21% decrease (P = 0.01) in fertility was observed between
20340 ABCA1(-/-) males compared with WT controls across their reproductive
20346 str
"Mar 7 2005 7:07PM" ,
20348 str
"Mar 7 2005 9:28PM" } ,
20351 text
"Verapamil increases ABCA1 expression through LXR-independent
20352 mechanism and thereby increases apoA-I-mediated cellular lipid release and
20353 production of HDL." ,
20358 str
"Jan 8 2005 10:01AM" ,
20360 str
"Jan 8 2005 2:49PM" } ,
20363 text
"In murine macrophage cell line RAW264 cells, cAMP induced
20364 expression of ABCA1, release of cellular phospholipid and cholesterol by
20365 apoA-I, and reversible binding of apoA-I to the cell." ,
20370 str
"Dec 4 2004 10:01AM" ,
20372 str
"Dec 4 2004 2:26PM" } ,
20375 text
"The time course and temperature dependence of ABCA1-mediated lipid
20376 efflux to apoA-I support a role for endocytosis in this process" ,
20381 str
"Dec 4 2004 10:01AM" ,
20383 str
"Dec 4 2004 11:09AM" } ,
20386 text
"conclude that intact ATP binding cassette transporter A1 (ABCA1)
20387 function is necessary for proper maturation of dense bodies in platelets" ,
20392 str
"Oct 30 2004 10:01AM" ,
20394 str
"Oct 30 2004 10:58AM" } ,
20397 text
"glial ABCA1 has a key role in apoE metabolism in the brain" ,
20402 str
"Oct 30 2004 10:01AM" ,
20404 str
"Oct 30 2004 10:43AM" } ,
20407 text
"ABCA1 plays a critical role in central nervous system apoE
20413 str
"Oct 30 2004 10:01AM" ,
20415 str
"Oct 30 2004 10:43AM" } ,
20418 text
"PPAR alpha influences cholesterol absorption through modulating
20419 the ATP binding cassette transporter A1 activity in the intestine by a
20420 mechanism involving liver X receptor alpha" ,
20425 str
"Aug 9 2004 1:01PM" ,
20427 str
"Aug 9 2004 1:41PM" } ,
20430 text
"When endotoxin or cytokines (tumor necrosis factor and
20431 interleukin-1) were incubated with J774 murine macrophages, the mRNA levels
20432 of ABCA1 were decreased." ,
20437 str
"Jul 12 2004 11:39AM" ,
20439 str
"Jul 12 2004 12:16PM" } ,
20442 text
"ABCA1 is stabilized by a specific structural element possessing a
20443 linear array of acidic residues spanning two apoA-I amphipathic alpha-helices" ,
20448 str
"Jul 12 2004 11:39AM" ,
20450 str
"Jul 12 2004 11:52AM" } ,
20453 text
"despite large induction of ABCA1 mRNA during differentiation,
20454 cholesterol efflux through the ABCA1 pathway remains limited in adipocytes
20455 and requires prolonged lipolysis" ,
20460 str
"Jun 23 2004 4:43PM" ,
20462 str
"Jun 23 2004 5:25PM" } ,
20465 text
"ABCA1 turnover is modulated by alpha1-syntrophin" ,
20470 str
"Jun 14 2004 4:41PM" ,
20472 str
"Jun 14 2004 5:46PM" } ,
20475 text
"Review. ABCA1-deficient mice are used to demonstrate the relation
20476 between ABCA1 expression, cellular lipid efflux, & HDL metabolism. The
20477 ABCA1-deficient mouse phenotype parallels that of human Tangier disease." ,
20482 str
"Jan 25 2004 12:00AM" ,
20484 str
"Feb 29 2004 7:03AM" } ,
20487 text
"cellular ATP-binding cassette transporter A1 has a role in
20488 transporting cholesterol and phospholipids from cells to lipoprotein
20489 particles by a process involving PLTP interactions" ,
20494 str
"Jan 20 2004 12:00AM" ,
20496 str
"Feb 15 2004 6:35PM" } ,
20499 text
"Results demonstrate that ABCA1 plays a key role in hepatic
20500 cholesterol efflux, inducing pathways that modulate cholesterol homeostasis
20501 in the liver, and establish the liver as a major source of plasma HDL-C." ,
20506 str
"Jan 5 2004 12:00AM" ,
20508 str
"Feb 29 2004 7:03AM" } ,
20511 text
"ABCA1-mediated vesicle release involves lipid raft plasma membrane
20517 str
"Nov 30 2003 12:00AM" ,
20519 str
"Jan 4 2004 7:03AM" } ,
20522 text
"These studies indicate a direct role of retinoic acid receptor
20523 gamma/retinoid x receptor in induction of macrophage ABCA1." ,
20528 str
"Nov 17 2003 12:00AM" ,
20530 str
"Dec 7 2003 7:05AM" } ,
20533 text
"As observed in knockout mice, ABCA1 is necessary for the adequate
20534 lipidation of apoAI, which enables the interaction with LCAT and subsequent
20540 str
"Sep 30 2003 12:00AM" ,
20542 str
"Oct 12 2003 7:03AM" } ,
20545 text
"ABCA1 and SREBP1 are regulated by liver X receptor/corepressor
20551 str
"Aug 25 2003 12:00AM" ,
20553 str
"Aug 31 2003 7:04AM" } ,
20556 text
"Estrogen's antiatherogenic effects may occur via ABCA1-mediated
20557 pathway, and circulating HDL levels may influence expression of ABCA1" ,
20562 str
"Jun 3 2003 12:00AM" ,
20564 str
"Jun 8 2003 7:28AM" } ,
20567 text
"Hepatocyte expression of ABCA1 is central to the lipidation of
20568 newly synthesized apoA-I but also contributes to the lipidation of exogenous
20574 str
"Apr 2 2003 12:00AM" ,
20576 str
"May 11 2003 7:05AM" } ,
20579 text
"Golgi is involved in ABCA1-mediated cholesterol efflux." ,
20584 str
"Apr 1 2003 12:00AM" ,
20586 str
"May 11 2003 7:05AM" } ,
20589 text
"ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux
20590 is promoted by central helices of ApoA-I; amino acid residues 220-231 of the
20591 wild-type ApoA-I are required for lipid efflux and high density lipoprotein
20597 str
"Mar 20 2003 12:00AM" ,
20599 str
"Apr 13 2003 7:04AM" } ,
20602 text
"annexin I is externalized from pituitary folliculo-stellate cells
20603 by an ABC transporter and the ATP binding cassette transporter A1 is a likely
20609 str
"Mar 19 2003 12:00AM" ,
20611 str
"Mar 31 2003 6:34AM" } ,
20614 text
"ATP-binding-cassette transporter A1 gene expression in macrophages
20615 is downregulated by statins" ,
20620 str
"Apr 26 2004 12:00AM" ,
20622 str
"May 23 2004 7:05AM" } ,
20625 text
"ABCA1 is regulated by PEST sequence-mediated calpain proteolysis
20626 that appears to be reversed by apolipoprotein-mediated phospholipid efflux" ,
20631 str
"Feb 7 2003 12:00AM" ,
20633 str
"Mar 9 2003 7:04AM" } ,
20636 text
"REVIEW: ATP-binding cassette transporter A1 and cholesterol
20642 str
"Jan 24 2003 12:00AM" ,
20644 str
"Feb 2 2003 7:50AM" } ,
20647 text
"mediates cholesterol efflux and is defective in free
20648 cholesterol-loaded macrophages; mechanism involves enhanced degradation and
20649 full npc1 activity." ,
20654 str
"Jan 16 2003 12:00AM" ,
20656 str
"Feb 9 2003 7:14AM" } ,
20659 text
"induction as a result of liver X receptor agonism increases
20660 secreted Abeta levels" ,
20665 str
"Jan 9 2003 12:00AM" ,
20667 str
"Feb 2 2003 7:50AM" } ,
20670 text
"Increased hepatobiliary and fecal cholesterol excretion upon
20671 activation of the liver X receptor is independent of ABCA1." ,
20676 str
"Nov 20 2002 12:00AM" ,
20678 str
"Feb 2 2003 7:50AM" } ,
20681 text
"A novel serine (Ser-2054) on the ABCA1 protein crucial for PKA
20682 phosphorylation and for regulation of ABCA1 transporter activity." ,
20687 str
"Nov 16 2002 12:00AM" ,
20689 str
"Feb 2 2003 7:50AM" } ,
20692 text
"studies establish a novel binding site for apoA-I on the
20693 macrophage extracellular matrix that may function together with ABCA1 in
20694 promoting cholesterol efflux" ,
20699 str
"Sep 27 2002 12:00AM" ,
20701 str
"Feb 2 2003 7:49AM" } ,
20704 text
"Role as a phosphatidylserine translocase" ,
20709 str
"Jul 8 2002 12:00AM" ,
20711 str
"Jul 22 2002 5:59AM" } ,
20714 text
"Leukocyte ABCA1 controls susceptibility to atherosclerosis and
20715 macrophage recruitment into tissues" ,
20720 str
"May 31 2002 12:00AM" ,
20722 str
"Jun 15 2002 8:10AM" } ,
20725 text
"Conditional disruption of the peroxisome proliferator-activated
20726 receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1,
20727 and apoE in macrophages and reduced cholesterol efflux." ,
20732 str
"Apr 16 2002 12:00AM" ,
20734 str
"Apr 28 2002 6:21PM" } ,
20737 text
"in the presence of apoE, overexpression of ABCA1 modulates HDL as
20738 well as apoB-containing lipoprotein metabolism and reduces atherosclerosis in
20744 str
"Apr 2 2002 12:00AM" ,
20746 str
"Apr 28 2002 6:21PM" } ,
20749 text
"ABCA1 is expressed in a pattern consistent with its role in HDL-C
20755 str
"Mar 27 2002 12:00AM" ,
20757 str
"Apr 8 2002 3:24PM" } ,
20760 text
"unsaturated fatty acids reduce the macrophage ABCA1 content by
20761 enhancing its degradation rate" ,
20766 str
"Mar 5 2002 12:00AM" ,
20768 str
"Apr 1 2002 5:34AM" } ,
20771 heading
"Alleles" ,
20776 text
"The following allele types are documented at Mouse Genome
20782 url
"http://www.informatics.jax.org/searches/allele_report.cgi?m
20783 arkerID=MGI:99607" } } } ,
20786 heading
"Targeted (knock-out) (2)" ,
20790 pmid
10980140 } } } } } ,
20822 type protein
-coding
,
20827 taxname
"Mus musculus" ,
20828 common
"house mouse" ,
20840 species
"musculus" } ,
20841 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
20842 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
20843 Sciurognathi; Muridae; Murinae; Mus" ,
20849 subtype chromosome
,
20853 desc
"ATP-binding cassette, sub-family A (ABC1), member 4" ,
20854 maploc
"3 61.8 cM" ,
20859 "D430003I15Rik" } ,
20860 locus
-tag
"MGI:109424" } ,
20863 "ATP-binding cassette, sub-family A, member 4" ,
20865 "ATP-binding cassette 10" } } ,
20866 summary
"The membrane-associated protein encoded by this gene is a member of
20867 the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins
20868 transport various molecules across extra- and intracellular membranes. ABC
20869 genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD,
20870 OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members
20871 of the ABC1 subfamily comprise the only major ABC subfamily found exclusively
20872 in multicellular eukaryotes. This protein was the first of the ABC
20873 transporters to be observed in photoreceptors and may play a role in the
20874 photoresponse. Mutations in the human gene are found in patients diagnosed
20875 with Stargardt disease and are associated with retinitis pigmentosa-19 and
20876 macular degeneration age-related 2." ,
20879 display-str
"3 G1" ,
20883 display-str
"3 61.8 cM" ,
20890 gene
-display FALSE
,
20891 locus
-display FALSE
,
20892 extra
-terms FALSE
} ,
20896 heading
"Reference" ,
20897 accession
"NC_000069" ,
20909 heading
"Reference" ,
20910 accession
"NM_007378" ,
21213 gi
51860767 } } } ,
21220 heading
"Reference" ,
21221 accession
"NP_031404" ,
21524 gi
51860767 } } } ,
21527 gi
6671495 } } } } } } ,
21530 heading
"Reference" ,
21531 accession
"NT_039240" ,
21543 heading
"Reference" ,
21544 accession
"NM_007378" ,
21847 gi
51708444 } } } ,
21854 heading
"Reference" ,
21855 accession
"NP_031404" ,
22158 gi
51708444 } } } ,
22161 gi
6671495 } } } } } } } ,
22165 label
"Nomenclature" ,
22169 anchor
"Mouse Genome Informatics" } } ,
22173 label
"Official Symbol" ,
22178 label
"Official Full Name" ,
22179 text
"ATP-binding cassette, sub-family A (ABC1), member 4" ,
22183 heading
"GeneOntology" ,
22187 pre
-text
"Provided by" ,
22189 url
"http://www.informatics.jax.org/" } } ,
22205 anchor
"ATP binding" ,
22206 post
-text
"evidence: IEA" } } } ,
22216 anchor
"ATPase activity" ,
22217 post
-text
"evidence: IEA" } } } ,
22229 anchor
"ATPase activity, coupled to transmembrane movement
22231 post
-text
"evidence: TAS" } } } ,
22243 anchor
"phospholipid transporter activity" ,
22244 post
-text
"evidence: IMP" } } } ,
22256 anchor
"phospholipid-translocating ATPase activity" ,
22257 post
-text
"evidence: IMP" } } } } } ,
22274 anchor
"phospholipid transfer to membrane" ,
22275 post
-text
"evidence: IMP" } } } ,
22287 anchor
"photoreceptor maintenance" ,
22288 post
-text
"evidence: IMP" } } } ,
22298 anchor
"sensory perception" ,
22299 post
-text
"evidence: IEA" } } } ,
22309 anchor
"transport" ,
22310 post
-text
"evidence: IEA" } } } ,
22322 anchor
"visual perception" ,
22323 post
-text
"evidence: IMP" } } } } } ,
22326 label
"Component" ,
22338 anchor
"integral to membrane" ,
22339 post
-text
"evidence: IEA" } } } ,
22351 anchor
"integral to plasma membrane" ,
22352 post
-text
"evidence: TAS" } } } } } } } } ,
22356 heading
"Human, Rat" ,
22364 anchor
"Map Viewer" ,
22365 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=3&
22366 MAPS=genes-r-org/human-chr/mouse%3A3,genes-r-org/rat-chr/mouse%3A3,genes-r-org
22367 /mouse-chr3&query=e%3A11304[id]+AND+gene[obj_type]&QSTR=abca4&cmd=focus&fill=1
22372 heading
"LocusTagLink" ,
22379 id
109424 } } } } ,
22382 heading
"RefSeq Status" ,
22402 heading
"Markers (Sequence Tagged Sites/STS)" ,
22415 post
-text
"(e-PCR)" } } ,
22419 label
"Alternate name" ,
22431 anchor
"AF000149" ,
22432 post
-text
"(e-PCR)" } } ,
22436 label
"Alternate name" ,
22441 label
"Alternate name" ,
22446 label
"Alternate name" ,
22448 version
0 } } } } } ,
22451 heading
"NCBI Reference Sequences (RefSeq)" ,
22456 heading
"mRNA Sequence" ,
22457 accession
"NM_007378" ,
22465 anchor
"NM_007378" } } ,
22472 heading
"Product" ,
22473 accession
"NP_031404" ,
22481 anchor
"NP_031404" ,
22482 post
-text
"ATP-binding cassette, sub-family A, member 4" } } ,
22489 heading
"Conserved Domains" ,
22498 anchor
"summary" } } ,
22509 anchor
"cd00267: ABC_ATPase; ABC (ATP-binding
22510 cassette) transporter nucleotide-binding domain" } } ,
22514 text
"Location: 931 - 1144 Blast Score: 454" ,
22518 text
"Location: 1937 - 2152 Blast Score: 353" ,
22529 anchor
"COG4152: COG4152; ABC-type uncharacterized
22530 transport system, ATPase component [General function prediction only]" } } ,
22534 text
"Location: 1937 - 2253 Blast Score: 387" ,
22535 version
0 } } } } } } } } ,
22539 heading
"Source Sequence" ,
22547 anchor
"AF000149" } } ,
22551 version
0 } } } } } } } ,
22554 heading
"Related Sequences" ,
22560 accession
"AF000149" ,
22568 anchor
"AF000149" } } ,
22575 accession
"AAC23916" ,
22583 anchor
"AAC23916" } } ,
22596 accession
"AK053043" ,
22604 anchor
"AK053043" } } ,
22622 accession
"AK084860" ,
22630 anchor
"AK084860" } } ,
22648 accession
"BC043937" ,
22656 anchor
"BC043937" } } ,
22663 accession
"AAH43937" ,
22671 anchor
"AAH43937" } } ,
22674 gi
27882180 } } } } ,
22678 accession
"BC057853" ,
22686 anchor
"BC057853" } } ,
22693 accession
"AAH57853" ,
22701 anchor
"AAH57853" } } ,
22704 gi
34783942 } } } } } } ,
22707 heading
"Additional Links" ,
22716 db
"Evidence Viewer" ,
22719 anchor
"Evidence Viewer" ,
22720 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
22721 ig=NT_039240.3&gene=Abca4&lid=11304&from=8569037&to=8704334" } } } ,
22731 anchor
"ModelMaker" ,
22732 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
22733 090&contig=NT_039240.3&gene=Abca4&lid=11304" } } } ,
22741 value
"Mm.3918" } } ,
22749 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=39
22760 anchor
"HomoloGene" ,
22761 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
22762 11304[loc]&TAXID=10090" } } } ,
22773 url
"http://www.informatics.jax.org/searches/accession_report.cg
22774 i?id=MGI:109424" } } } ,
22784 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=BC057
22795 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
22799 text
"Human ABC-Transporter Proteins" ,
22804 db
"Human ABC-Transporter Proteins" ,
22806 str
"Human ABC-Transporter Proteins" } ,
22807 anchor
"Human ABC-Transporter Proteins" ,
22808 url
"http://nutrigene.4t.com/humanabc.htm" } } } } } ,
22811 heading
"Alleles" ,
22816 text
"The following allele types are documented at Mouse Genome
22822 url
"http://www.informatics.jax.org/searches/allele_report.cgi?m
22823 arkerID=MGI:109424" } } } ,
22826 heading
"Targeted (knock-out) (1)" ,
22829 pmid
10412977 } } } } } ,
22861 type protein
-coding
,
22866 taxname
"Mus musculus" ,
22867 common
"house mouse" ,
22879 species
"musculus" } ,
22880 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
22881 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
22882 Sciurognathi; Muridae; Murinae; Mus" ,
22888 subtype chromosome
,
22892 desc
"ATP-binding cassette, sub-family A (ABC1), member 2" ,
22893 maploc
"2 12.6 cM" ,
22898 locus
-tag
"MGI:99606" } ,
22901 "ATP-binding cassette, sub-family A (ABC1), member 2" ,
22902 "ATP-binding cassette 2" } } ,
22905 display-str
"2 A2-B" ,
22909 display-str
"2 12.6 cM" ,
22916 gene
-display FALSE
,
22917 locus
-display FALSE
,
22918 extra
-terms FALSE
} ,
22922 heading
"Reference" ,
22923 accession
"NC_000068" ,
22935 heading
"Reference" ,
22936 accession
"NM_007379" ,
23227 gi
51860766 } } } ,
23234 heading
"Reference" ,
23235 accession
"NP_031405" ,
23526 gi
51860766 } } } ,
23529 gi
11993939 } } } } } } ,
23532 heading
"Reference" ,
23533 accession
"NT_039206" ,
23545 heading
"Reference" ,
23546 accession
"NM_007379" ,
23837 gi
51706164 } } } ,
23844 heading
"Reference" ,
23845 accession
"NP_031405" ,
24136 gi
51706164 } } } ,
24139 gi
11993939 } } } } } } } ,
24143 label
"Nomenclature" ,
24147 anchor
"Mouse Genome Informatics" } } ,
24151 label
"Official Symbol" ,
24156 label
"Official Full Name" ,
24157 text
"ATP-binding cassette, sub-family A (ABC1), member 2" ,
24161 heading
"GeneOntology" ,
24165 pre
-text
"Provided by" ,
24167 url
"http://www.informatics.jax.org/" } } ,
24183 anchor
"ATP binding" ,
24184 post
-text
"evidence: IEA" } } } ,
24194 anchor
"ATPase activity" ,
24195 post
-text
"evidence: IEA" } } } ,
24207 anchor
"transporter activity" ,
24208 post
-text
"evidence: ISS" } } } } } ,
24223 anchor
"cholesterol metabolism" ,
24224 post
-text
"evidence: ISS" } } } ,
24234 anchor
"transport" ,
24235 post
-text
"evidence: IEA" } } } } } ,
24238 label
"Component" ,
24252 anchor
"integral to membrane" ,
24253 post
-text
"evidence: TAS" } } } ,
24263 anchor
"lysosomal membrane" ,
24264 post
-text
"evidence: ISS" } } } } } } } } ,
24268 heading
"Human, Rat" ,
24276 anchor
"Map Viewer" ,
24277 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=2&
24278 MAPS=genes-r-org/human-chr/mouse%3A2,genes-r-org/rat-chr/mouse%3A2,genes-r-org
24279 /mouse-chr2&query=e%3A11305[id]+AND+gene[obj_type]&QSTR=abca2&cmd=focus&fill=1
24284 heading
"LocusTagLink" ,
24294 heading
"RefSeq Status" ,
24295 label
"PROVISIONAL" ,
24306 heading
"Markers (Sequence Tagged Sites/STS)" ,
24318 anchor
"AI413825" ,
24319 post
-text
"(e-PCR)" } } ,
24323 label
"Alternate name" ,
24325 version
0 } } } } } ,
24328 heading
"NCBI Reference Sequences (RefSeq)" ,
24333 heading
"mRNA Sequence" ,
24334 accession
"NM_007379" ,
24342 anchor
"NM_007379" } } ,
24349 heading
"Product" ,
24350 accession
"NP_031405" ,
24358 anchor
"NP_031405" ,
24359 post
-text
"ATP-binding cassette, sub-family A (ABC1), member
24367 heading
"Conserved Domains" ,
24376 anchor
"summary" } } ,
24387 anchor
"cd00267: ABC_ATPase; ABC (ATP-binding
24388 cassette) transporter nucleotide-binding domain" } } ,
24392 text
"Location: 1018 - 1205 Blast Score: 389" ,
24396 text
"Location: 2051 - 2269 Blast Score: 372" ,
24397 version
0 } } } } } } } } ,
24401 heading
"Source Sequence" ,
24409 anchor
"X75927" } } ,
24413 version
0 } } } } } } } ,
24416 heading
"Related Sequences" ,
24422 accession
"AK129274" ,
24430 anchor
"AK129274" } } ,
24437 accession
"BAC98084" ,
24445 anchor
"BAC98084" } } ,
24448 gi
37360212 } } } } ,
24452 accession
"X75927" ,
24460 anchor
"X75927" } } ,
24467 accession
"CAA53531" ,
24475 anchor
"CAA53531" } } ,
24478 gi
11990231 } } } ,
24492 accession
"P41234" ,
24500 anchor
"P41234" } } ,
24503 gi
14916951 } } } } } } ,
24506 heading
"Additional Links" ,
24515 db
"Evidence Viewer" ,
24518 anchor
"Evidence Viewer" ,
24519 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
24520 ig=NT_039206.3&gene=Abca2&lid=11305&from=2857416&to=2876845" } } } ,
24530 anchor
"ModelMaker" ,
24531 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
24532 090&contig=NT_039206.3&gene=Abca2&lid=11305" } } } ,
24540 value
"Mm.2210" } } ,
24548 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=22
24559 anchor
"HomoloGene" ,
24560 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
24561 11305[loc]&TAXID=10090" } } } ,
24572 url
"http://www.informatics.jax.org/searches/accession_report.cg
24573 i?id=MGI:99606" } } } ,
24583 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=X7592
24594 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
24598 text
"Human ABC-Transporter Proteins" ,
24603 db
"Human ABC-Transporter Proteins" ,
24605 str
"Human ABC-Transporter Proteins" } ,
24606 anchor
"Human ABC-Transporter Proteins" ,
24607 url
"http://nutrigene.4t.com/humanabc.htm" } } } } } } ,
24639 type protein
-coding
,
24644 taxname
"Mus musculus" ,
24645 common
"house mouse" ,
24657 species
"musculus" } ,
24658 lineage
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
24659 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
24660 Sciurognathi; Muridae; Murinae; Mus" ,
24666 subtype chromosome
,
24670 desc
"ATP-binding cassette, sub-family B (MDR/TAP), member 7" ,
24671 maploc
"X 39.0 cM" ,
24674 locus
-tag
"MGI:109533" } ,
24677 "ATP-binding cassette, sub-family B (MDR/TAP), member 7" ,
24678 "ATP-binding cassette 7" } } ,
24681 display-str
"X C-D" ,
24685 display-str
"X 39.0 cM" ,
24692 gene
-display FALSE
,
24693 locus
-display FALSE
,
24694 extra
-terms FALSE
} ,
24698 heading
"Reference" ,
24699 accession
"NC_000086" ,
24711 heading
"Reference" ,
24712 accession
"XM_356348" ,
24811 gi
51869957 } } } ,
24818 heading
"Reference" ,
24819 accession
"XP_356348" ,
24918 gi
51869957 } } } ,
24921 gi
38086485 } } } } } } ,
24924 heading
"Reference" ,
24925 accession
"NT_039711" ,
24937 heading
"Reference" ,
24938 accession
"XM_356348" ,
25037 gi
51772331 } } } ,
25044 heading
"Reference" ,
25045 accession
"XP_356348" ,
25144 gi
51772331 } } } ,
25147 gi
38086485 } } } } } } } ,
25151 label
"Nomenclature" ,
25155 anchor
"Mouse Genome Informatics" } } ,
25159 label
"Official Symbol" ,
25164 label
"Official Full Name" ,
25165 text
"ATP-binding cassette, sub-family B (MDR/TAP), member 7" ,
25169 heading
"GeneOntology" ,
25173 pre
-text
"Provided by" ,
25175 url
"http://www.informatics.jax.org/" } } ,
25191 anchor
"ATP binding" ,
25192 post
-text
"evidence: IEA" } } } ,
25202 anchor
"ATPase activity" ,
25203 post
-text
"evidence: IEA" } } } ,
25213 anchor
"ATPase activity, coupled to transmembrane movement
25215 post
-text
"evidence: IEA" } } } ,
25225 anchor
"nucleoside-triphosphatase activity" ,
25226 post
-text
"evidence: IEA" } } } ,
25236 anchor
"nucleotide binding" ,
25237 post
-text
"evidence: IEA" } } } } } ,
25252 anchor
"transport" ,
25253 post
-text
"evidence: IEA" } } } } } ,
25256 label
"Component" ,
25268 anchor
"inner membrane" ,
25269 post
-text
"evidence: IEA" } } } ,
25279 anchor
"integral to membrane" ,
25280 post
-text
"evidence: IEA" } } } ,
25290 anchor
"membrane" ,
25291 post
-text
"evidence: IEA" } } } ,
25301 anchor
"mitochondrion" ,
25302 post
-text
"evidence: IEA" } } } } } } } } ,
25306 heading
"Human, Rat" ,
25314 anchor
"Map Viewer" ,
25315 url
"http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=X&
25316 MAPS=genes-r-org/human-chr/mouse%3AX,genes-r-org/rat-chr/mouse%3AX,genes-r-org
25317 /mouse-chrX&query=e%3A11306[id]+AND+gene[obj_type]&QSTR=abcb7&cmd=focus&fill=1
25322 heading
"LocusTagLink" ,
25329 id
109533 } } } } ,
25332 heading
"RefSeq Status" ,
25350 heading
"Markers (Sequence Tagged Sites/STS)" ,
25362 anchor
"RH124283" ,
25363 post
-text
"(e-PCR)" } } } ,
25373 anchor
"AW537380" ,
25374 post
-text
"(e-PCR)" } } ,
25378 label
"Alternate name" ,
25390 anchor
"AU019072" ,
25391 post
-text
"(e-PCR)" } } ,
25395 label
"Alternate name" ,
25397 version
0 } } } } } ,
25400 heading
"NCBI Reference Sequences (RefSeq)" ,
25405 heading
"mRNA Sequence" ,
25406 accession
"XM_356348" ,
25414 anchor
"XM_356348" } } ,
25421 accession
"XP_356348" ,
25429 anchor
"XP_356348" } } ,
25436 heading
"Conserved Domains" ,
25445 anchor
"summary" } } ,
25456 anchor
"cd00267: ABC_ATPase; ABC (ATP-binding
25457 cassette) transporter nucleotide-binding domain" } } ,
25461 text
"Location: 496 - 714 Blast Score: 577" ,
25472 anchor
"COG5265: ATM1; ABC-type transport system
25473 involved in Fe-S cluster assembly, permease and ATPase components
25474 [Posttranslational modification, protein turnover, chaperones]" } } ,
25478 text
"Location: 234 - 729 Blast Score: 1506" ,
25489 anchor
"pfam00664: ABC_membrane; ABC transporter
25490 transmembrane region" } } ,
25494 text
"Location: 164 - 435 Blast Score: 247" ,
25495 version
0 } } } } } } } } } } } ,
25498 heading
"Related Sequences" ,
25504 accession
"AA517758" ,
25512 anchor
"AA517758" } } ,
25525 text
"C57BL/6J x DBA/2J F1" ,
25530 accession
"AK040069" ,
25538 anchor
"AK040069" } } ,
25556 accession
"AK084853" ,
25564 anchor
"AK084853" } } ,
25582 accession
"AU019072" ,
25590 anchor
"AU019072" } } ,
25608 accession
"AW537380" ,
25616 anchor
"AW537380" } } ,
25634 accession
"BC035534" ,
25642 anchor
"BC035534" } } ,
25654 accession
"U43892" ,
25662 anchor
"U43892" } } ,
25669 accession
"AAC53152" ,
25677 anchor
"AAC53152" } } ,
25694 accession
"Q61102" ,
25702 anchor
"Q61102" } } ,
25705 gi
5902709 } } } } } } ,
25708 heading
"Additional Links" ,
25717 db
"Evidence Viewer" ,
25720 anchor
"Evidence Viewer" ,
25721 url
"http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
25722 ig=NT_039711.3&gene=Abcb7&lid=11306&from=9312470&to=9445709" } } } ,
25732 anchor
"ModelMaker" ,
25733 url
"http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
25734 090&contig=NT_039711.3&gene=Abcb7&lid=11306" } } } ,
25742 value
"Mm.262053" } } ,
25748 str
"Mm.262053" } ,
25749 anchor
"Mm.262053" ,
25750 url
"http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=26
25761 anchor
"HomoloGene" ,
25762 url
"http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
25763 11306[loc]&TAXID=10090" } } } ,
25774 url
"http://www.informatics.jax.org/searches/accession_report.cg
25775 i?id=MGI:109533" } } } ,
25785 url
"http://www.ensembl.org/Mus_musculus/contigview?geneid=BC035
25796 url
"http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
25800 text
"Gene Expression Database (GXD) at MGI" ,
25805 db
"Gene Expression Database (GXD) at MGI" ,
25807 str
"MGI:109533" } ,
25808 anchor
"MGI:109533" ,
25809 url
"http://www.informatics.jax.org/searches/expression_report.c
25810 gi?id=MGI:109533" } } } ,
25813 text
"Human ABC-Transporter Proteins" ,
25818 db
"Human ABC-Transporter Proteins" ,
25820 str
"Human ABC-Transporter Proteins" } ,
25821 anchor
"Human ABC-Transporter Proteins" ,
25822 url
"http://nutrigene.4t.com/humanabc.htm" } } } } } ,
25825 text
"ABC7 positively regulates the expression of extramitochondrial
25826 thioredoxin & that of an intramitochondrial iron-sulfur-containing protein,
25827 ferrochelatase. ABC7 contributes to the production of heme during the
25828 differentiation of erythroid cells." ,
25833 str
"May 23 2003 12:00AM" ,
25835 str
"Jun 22 2003 7:07AM" } } ,
25867 type protein
-coding
,
25872 taxname
"Caenorhabditis elegans" ,
25881 genus
"Caenorhabditis" ,
25882 species
"elegans" } ,
25883 lineage
"Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida;
25884 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis" ,
25890 subtype chromosome
,
25894 maploc
"I;-17.75 cM (interpolated genetic position)" ,
25897 db
"AceView/WormGenes" ,
25907 str
"Y74C9A.3" } } ,
25911 locus
-tag
"1A478" } ,
25914 "AD-003 protein (26.6 kD) (1A478)" } } ,
25919 display-str
"I;-17.75 cM (interpolated genetic position)" ,
25923 src
"Entrez Genomes" ,
25925 src
-str1
"NC_003279" ,
25926 src
-str2
"CE:1A478" ,
25927 gene
-display FALSE
,
25928 locus
-display FALSE
,
25929 extra
-terms FALSE
} ,
25934 accession
"NC_003279" ,
25946 accession
"NM_058260" ,
25981 gi
25167480 } } } ,
25988 label
"AD-003 protein (26.6 kD) (1A478)" ,
25989 accession
"NP_490660" ,
26024 gi
25167480 } } } ,
26027 gi
17510631 } } } ,
26032 version
0 } } } } ,
26036 text
"Title: Caenorhabditis elegans gene 1A478, AD-003 protein." ,
26037 version
0 } } } } ,
26041 heading
"NCBI Reference Sequences (RefSeq)" ,
26046 heading
"mRNA Sequence" ,
26047 accession
"NM_058260" ,
26055 anchor
"NM_058260" } } ,
26062 heading
"Product" ,
26063 accession
"NP_490660" ,
26071 anchor
"NP_490660" } } ,
26078 heading
"Conserved Domains" ,
26087 anchor
"summary" } } ,
26098 anchor
"pfam05891: DUF858; Eukaryotic protein of
26099 unknown function (DUF858)" } } ,
26103 text
"Location: 11 - 225 Blast Score: 824" ,
26104 version
0 } } } } } } } } } } } ,
26107 heading
"Related Sequences" ,
26112 heading
"Genomic" ,
26113 accession
"AC024206" ,
26121 anchor
"AC024206" } } ,
26128 accession
"AAF36050" ,
26136 anchor
"AAF36050" } } ,
26139 gi
14550391 } } } } } } ,
26142 heading
"RefSeq Status" ,
26153 value
"7105656" } ,
26156 value
"14550391" } } ,
26182 type protein
-coding
,
26187 taxname
"Caenorhabditis elegans" ,
26196 genus
"Caenorhabditis" ,
26197 species
"elegans" } ,
26198 lineage
"Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida;
26199 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis" ,
26205 subtype chromosome
,
26209 maploc
"I;-17.80 cM (interpolated genetic position)" ,
26212 db
"AceView/WormGenes" ,
26222 str
"Y74C9A.2" } } ,
26226 locus
-tag
"1A489" } ,
26229 "putative protein, with a coiled coil-4 domain (13.7 kD) (1A489)" } } ,
26234 display-str
"I;-17.80 cM (interpolated genetic position)" ,
26238 src
"Entrez Genomes" ,
26240 src
-str1
"NC_003279" ,
26241 src
-str2
"CE:1A489" ,
26242 gene
-display FALSE
,
26243 locus
-display FALSE
,
26244 extra
-terms FALSE
} ,
26249 accession
"NC_003279" ,
26261 accession
"NM_058259" ,
26284 gi
25167480 } } } ,
26291 label
"putative protein, with a coiled coil-4 domain (13.7 kD)
26293 accession
"NP_490661" ,
26317 gi
25167480 } } } ,
26320 gi
17510629 } } } ,
26325 version
0 } } } } ,
26329 text
"Title: Caenorhabditis elegans essential expressed gene 1A489." ,
26330 version
0 } } } } ,
26334 heading
"NCBI Reference Sequences (RefSeq)" ,
26339 heading
"mRNA Sequence" ,
26340 accession
"NM_058259" ,
26348 anchor
"NM_058259" } } ,
26355 heading
"Product" ,
26356 accession
"NP_490661" ,
26364 anchor
"NP_490661" } } ,
26367 gi
17510629 } } } } } } ,
26370 heading
"Related Sequences" ,
26375 heading
"Genomic" ,
26376 accession
"AC024206" ,
26384 anchor
"AC024206" } } ,
26391 accession
"AAF36049" ,
26399 anchor
"AAF36049" } } ,
26402 gi
7105658 } } } } } } ,
26405 heading
"RefSeq Status" ,
26416 value
"7105656" } ,
26419 value
"7105658" } } ,
26445 type protein
-coding
,
26450 taxname
"Caenorhabditis elegans" ,
26459 genus
"Caenorhabditis" ,
26460 species
"elegans" } ,
26461 lineage
"Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida;
26462 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis" ,
26468 subtype chromosome
,
26472 maploc
"I;-17.86 cM (interpolated genetic position)" ,
26475 db
"AceView/WormGenes" ,
26485 str
"Y74C9A.4a" } } ,
26490 locus
-tag
"1A492" } ,
26493 "suppressor of PResenilin defect SPR-1 related; similar to co-repressor
26494 of REST RE1-silencing transcription factor (65.9 kD) (1A492)" ,
26495 "suppressor of PResenilin defect SPR-1 related; similar to co-repressor
26496 of REST RE1-silencing transcription factor (65.6 kD) (1A492)" } } ,
26499 display-str
"I;-17.86 cM (interpolated genetic position)" ,
26503 src
"Entrez Genomes" ,
26505 src
-str1
"NC_003279" ,
26506 src
-str2
"CE:1A492" ,
26507 gene
-display FALSE
,
26508 locus
-display FALSE
,
26509 extra
-terms FALSE
} ,
26514 accession
"NC_003279" ,
26526 accession
"NM_058261" ,
26603 gi
25167480 } } } ,
26610 label
"suppressor of PResenilin defect SPR-1 related; similar to
26611 co-repressor of REST RE1-silencing transcription factor (65.9 kD) (1A492)" ,
26612 accession
"NP_490662" ,
26689 gi
25167480 } } } ,
26692 gi
17510633 } } } ,
26700 accession
"NM_058262" ,
26777 gi
25167480 } } } ,
26784 label
"suppressor of PResenilin defect SPR-1 related; similar to
26785 co-repressor of REST RE1-silencing transcription factor (65.6 kD) (1A492)" ,
26786 accession
"NP_490663" ,
26863 gi
25167480 } } } ,
26866 gi
17510635 } } } ,
26871 version
0 } } } } ,
26875 text
"Title: Caenorhabditis elegans gene 1A492, suppressor of
26876 PResenilin defect SPR-1 related; similar to co-repressor of REST
26877 RE1-silencing transcription factor." ,
26878 version
0 } } } } ,
26882 heading
"NCBI Reference Sequences (RefSeq)" ,
26887 heading
"mRNA Sequence" ,
26888 accession
"NM_058261" ,
26896 anchor
"NM_058261" } } ,
26903 heading
"Product" ,
26904 accession
"NP_490662" ,
26912 anchor
"NP_490662" } } ,
26915 gi
17510633 } } } } ,
26918 heading
"mRNA Sequence" ,
26919 accession
"NM_058262" ,
26927 anchor
"NM_058262" } } ,
26934 heading
"Product" ,
26935 accession
"NP_490663" ,
26943 anchor
"NP_490663" } } ,
26946 gi
17510635 } } } } } } ,
26949 heading
"Related Sequences" ,
26954 heading
"Genomic" ,
26955 accession
"AC024206" ,
26963 anchor
"AC024206" } } ,
26970 accession
"AAK67240" ,
26978 anchor
"AAK67240" } } ,
26981 gi
14550392 } } } } ,
26984 heading
"Genomic" ,
26985 accession
"AC024206" ,
26993 anchor
"AC024206" } } ,
27000 accession
"AAF36052" ,
27008 anchor
"AAF36052" } } ,
27011 gi
7105661 } } } } } } ,
27014 heading
"RefSeq Status" ,
27025 value
"7105656" } ,
27028 value
"14550392" } ,
27031 value
"7105661" } } ,
27057 type protein
-coding
,
27062 taxname
"Caenorhabditis elegans" ,
27071 genus
"Caenorhabditis" ,
27072 species
"elegans" } ,
27073 lineage
"Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida;
27074 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis" ,
27080 subtype chromosome
,
27084 maploc
"I;-17.91 cM (interpolated genetic position)" ,
27087 db
"AceView/WormGenes" ,
27097 str
"Y74C9A.5" } } ,
27101 locus
-tag
"1A502" } ,
27104 "sestrin (1A502)" } } ,
27109 display-str
"I;-17.91 cM (interpolated genetic position)" ,
27113 src
"Entrez Genomes" ,
27115 src
-str1
"NC_003279" ,
27116 src
-str2
"CE:1A502" ,
27117 gene
-display FALSE
,
27118 locus
-display FALSE
,
27119 extra
-terms FALSE
} ,
27124 accession
"NC_003279" ,
27136 accession
"NM_058263" ,
27189 gi
25167480 } } } ,
27196 label
"sestrin (1A502)" ,
27197 accession
"NP_490664" ,
27250 gi
25167480 } } } ,
27253 gi
17510637 } } } ,
27258 version
0 } } } } ,
27262 text
"Title: Caenorhabditis elegans gene 1A502, sestrin." ,
27263 version
0 } } } } ,
27267 heading
"NCBI Reference Sequences (RefSeq)" ,
27272 heading
"mRNA Sequence" ,
27273 accession
"NM_058263" ,
27281 anchor
"NM_058263" } } ,
27288 heading
"Product" ,
27289 accession
"NP_490664" ,
27297 anchor
"NP_490664" } } ,
27304 heading
"Conserved Domains" ,
27313 anchor
"summary" } } ,
27324 anchor
"pfam04636: PA26; PA26 p53-induced protein
27329 text
"Location: 88 - 644 Blast Score: 1457" ,
27330 version
0 } } } } } } } } } } } ,
27333 heading
"Related Sequences" ,
27338 heading
"Genomic" ,
27339 accession
"AC024206" ,
27347 anchor
"AC024206" } } ,
27354 accession
"AAF36051" ,
27362 anchor
"AAF36051" } } ,
27365 gi
7105660 } } } } } } ,
27368 heading
"RefSeq Status" ,
27379 value
"7105656" } ,
27382 value
"7105660" } } ,
27408 type protein
-coding
,
27413 taxname
"Caenorhabditis elegans" ,
27422 genus
"Caenorhabditis" ,
27423 species
"elegans" } ,
27424 lineage
"Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida;
27425 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis" ,
27431 subtype chromosome
,
27435 maploc
"I;-18.07 cM (interpolated genetic position)" ,
27438 db
"AceView/WormGenes" ,
27448 str
"Y48G1C.4" } } ,
27452 locus
-tag
"1A527" } ,
27455 "putative phosphatidylglycerophosphate synthase, similar to
27456 silencer-associated factor (51.7 kD) (1A527)" } } ,
27461 display-str
"I;-18.07 cM (interpolated genetic position)" ,
27465 src
"Entrez Genomes" ,
27467 src
-str1
"NC_003279" ,
27468 src
-str2
"CE:1A527" ,
27469 gene
-display FALSE
,
27470 locus
-display FALSE
,
27471 extra
-terms FALSE
} ,
27476 accession
"NC_003279" ,
27488 accession
"NM_058265" ,
27535 gi
25167480 } } } ,
27542 label
"putative phosphatidylglycerophosphate synthase, similar
27543 to silencer-associated factor (51.7 kD) (1A527)" ,
27544 accession
"NP_490666" ,
27592 gi
25167480 } } } ,
27595 gi
25143331 } } } ,
27600 version
0 } } } } ,
27604 text
"Title: Caenorhabditis elegans essential gene 1A527, putative
27605 phosphatidylglycerophosphate synthase, similar to silencer-associated factor." ,
27606 version
0 } } } } ,
27610 heading
"NCBI Reference Sequences (RefSeq)" ,
27615 heading
"mRNA Sequence" ,
27616 accession
"NM_058265" ,
27624 anchor
"NM_058265" } } ,
27631 heading
"Product" ,
27632 accession
"NP_490666" ,
27640 anchor
"NP_490666" } } ,
27647 heading
"Conserved Domains" ,
27656 anchor
"summary" } } ,
27667 anchor
"cd00138: PLDc; Phospholipase D" } } ,
27671 text
"Location: 20 - 172 Blast Score: 135" ,
27672 version
0 } } } } } } } } } } } ,
27675 heading
"Related Sequences" ,
27680 heading
"Genomic" ,
27681 accession
"AC024796" ,
27689 anchor
"AC024796" } } ,
27696 accession
"AAK29892" ,
27704 anchor
"AAK29892" } } ,
27707 gi
16950493 } } } } } } ,
27710 heading
"RefSeq Status" ,
27721 value
"7140352" } ,
27724 value
"16950493" } } ,