1 ---------------------------------------------------------
2 Revision history for BioPerl core modules
3 ---------------------------------------------------------
4 The comprehensive history and ongoing development of BioPerl:
6 http://github.com/bioperl/bioperl-live
8 Some of that history is also highlighted on our wiki:
10 http://www.bioperl.org/wiki/Change_log
11 http://www.bioperl.org/wiki/History_of_BioPerl
13 Bugs and requested features list:
15 https://redmine.open-bio.org/projects/bioperl
17 CPAN releases are branched from 'master'.
18 ---------------------------------------------------------
22 * Major Windows support updates! [fjossandon]
23 * MAKER update to allow for stricter standard codon table [cjfields]
24 * Better support for circular sequences [fjossandon]
25 * Fixes for some complex location types [fjossandon]
26 * Address CONTIG bug in GenBank format, bug #3448 [cjfields]
27 * Fix bug #2978 related to BLAST report type [fjossandon]
28 * Deobfuscator fixes [DaveMessina]
32 * Address CPAN test failures [cjfields]
33 * Add BIOPROJECT support for Genbank files [hyphaltip]
34 * Better regex support for HMMER3 output [bosborne]
38 * Minor update to address CPAN test failures
42 * Remove Bio::Biblio and related files [carandraug]
43 - this cause version clashes with an independently-released
44 version of Bio::Biblio
50 * Hash randomization fixes for perl 5.18.x
51 - Note: at least one module (Bio::Map::Physical) still has a failing test;
52 this is documented in bug #3446 and has been TODO'd; we will be pulling
53 Bio::Map and similar modules out of core into separate distributions in the
54 1.7.x release series [cjfields]
58 * Bio::Seq::SimulatedRead
59 - New module to represent reads taken from other sequences [fangly]
61 - New regexp() method to create regular expressions from IUPAC sequences
63 * Bio::SeqFeature::Primer and Bio::Seq::PrimedSeq:
64 - Code refresh [fangly]
66 - Added support for the Greengenes and Silva taxonomies [fangly]
67 * Bio::Tree::TreeFunctionsI
68 - get_lineage_string() represents a lineage as a string [fangly]
69 - add_trait() returns instead of reporting an error when the column
70 number is exceeded in add_trait() [fangly]
71 - Option to support tree leaves without trait [fangly]
72 - Allow ID of 0 in trait files [fangly]
73 * Bio::DB::Taxonomy::list
74 - Misc optimizations [fangly]
75 - Option -names of get_taxon() to help with ambiguous taxa [fangly]
76 * Bio::DB::Taxonomy::*
77 - get_num_taxa() returns the number of taxa in the database [fangly]
78 * Bio::DB::Fasta and Bio::DB::Qual
79 - support indexing an arbitrary list of files [fangly]
80 - user can supply an arbitrary index file name [fangly]
81 - new option to remove index file at the end [fangly]
83 - now handles IUPAC degenerate residues [fangly]
84 * Bio::PrimarySeq and Bio::PrimarySeqI
85 - speed improvements for large sequences [Ben Woodcroft, fangly]
87 - tightened and optimized quality string validation [fangly]
89 - new method and option 'block', to create FASTA output with space
90 intervaled blocks (similar to genbank or EMBL) has been implemented.
91 - package variables $WIDTH and $DEFAULT_SEQ_ID_TYPE have been removed
92 in favour of the methods 'width' and 'preferred_id_type` respectively.
94 - moved from bioperl-live into the separate distribution Bio-FeatureIO
95 * Bio::SeqFeature::Annotated
96 - moved from bioperl-live into the separate distribution Bio-FeatureIO
97 * Bio::Cluster::SequenceFamily
98 - improved performance when using get_members with overlapping multiple
100 * Bio::SearchIO::hmmer3
101 - now supports nhmmer [bosborne]
105 * [3302] Fixes bug in Bio::SearchIO::hmmer2.pm to correctly parse
106 multi-query hmmer output [Francisco J. Ossandon, Paul Cantalupo]
107 * [3421] Fixes bug in Bio::SearchIO::hmmer2.pm to correctly parse an HSP
108 with a line full of dashes [Francisco J. Ossandon, Paul Cantalupo]
109 * [3298] Fix bug in Bio::SearchIO::blast.pm where algorithm version
110 information was lost in a multi-result blast file [Paul Cantalupo]
111 * [3343] Fix bug in Bio::SearchIO::blasttable.pm to correctly calculate
112 total gaps [Paul Cantalupo]
113 * [3375] Fix DBLINK parsing bug in Bio::SeqIO::genbank.pm [Paul Cantalupo]
114 * [3376] Fix bug in Bio::SearchIO::hmmer2.pm to correctly handle case
115 when end of domain indicator is split across lines [Paul Cantalupo]
116 * [3240] Bio::AlignIO::stockholm now parses simple sequences [Bernd Web,
118 * [3237] Bio::DB::Fasta now allows blank lines between sequences, catches
119 instances where blank lines are within sequences [cjfields]
120 * Bio::DB::Fasta reports correct alphabet for files with multiple sequence
122 * Bio::DB::Fasta rev-comps sequences other than DNA properly [fangly]
123 * [3238] Fixes for Bio::DB::SeqFeature::Store::DBI::Pg [Thomas Burkhard,
125 * Various fixes for Stockholm file indexing and processing [bosborne]
126 * Fix edge case in FASTQ parsing where sequence of length 1 and qual of 0
127 breaks parsing [cjfields]
128 * Fix case where Bio::Seq::Meta* objects with no meta information could not
129 be reverse-complemented [fangly]
130 * Fix bug for fields without aliases in Bio::DB::Query::HIVQuery [fangly]
131 * Fix Bio::PopGen::IO::phase: sort values lexically instead of numerically
132 when unsure that values will be numerical [fangly]
133 * Fix undef warnings in Bio::SeqIO::embl [fangly]
134 * Fix undef warnings in Bio::DB::Fasta and Bio::DB::Qual [fangly]
135 * Fix Bio::Tools::IUPAC should accept any sequence object [fangly]
136 * Fix for 'Inappropriate ioctl' in Bio::DB::Store::berkeleydb3 [Olivier
138 * Bio::SeqFeature::Generic SeqfeatureI compliance: methods primary_tag,
139 source_tag and display_name must return a string, not undef [fangly]
140 * Bio::SimpleAlign and Bio::Seq compliance with Bio::FeatureHolderI
141 add_SeqFeature takes a single argument [fangly]
142 * Use cross-platform filenames and temporary directory in
143 Bio::DB::Taxonomy::flatfile [fangly]
144 * Fix bug in Bio::DB::Taxonomy::list where taxa with no ancestors were not
145 properly identified as existing taxa in the database [fangly]
146 * Fix issue where a Bio::DB::Taxonomy::list object could not be created
147 without also passing a lineage to store [fangly]
148 * Prevent passing a directory to the gi2taxid option (-g) of
149 bp_classify_hits_kingdom.pl and remove an 'earlier declaration' warning
151 * Fixed bp_genbank2gff3.pl crash when missing source feature date [fangly]
152 * Bio::PrimarySeq constructor -direct works for -seq or -ref_to_seq [fangly]
153 * Bio::Cluster::SequenceFamily - checks if the sequence has a Bio::Species
154 object before trying to access, and no longer returns repeated sequences.
161 * Use of AcePerl is deprecated; Ace.pm isn't actively maintained, and
162 modules using Ace will also be deprecated [lds, cjfields]
163 * Minor bug fix release
164 * Bio::SeqIO::gbxml tests require XML::SAX [hartzell]
165 * Address Build.PL issues when DBI is not present [hartzell]
166 * Skip gbxml.t and Interpro tests when modules not installed [cjfields]
167 * Remove deprecated code for perl 5.14.0 compat [cjfields]
168 * Due to schema changes and lack of support for older versions, support
169 for NeXML 0.9 is only (very) partially implemented.
170 See: https://redmine.open-bio.org/issues/3207
174 * [3205] - small fix to Bio::Perl blast_sequence() to make compliant with
175 docs [genehack, cjfields]
176 * $VERSION for CPAN/cpanm-based installs was broken; force setting of
177 module version from dist_version (probably not the best way to do this,
178 but it seems to work) [rbuels, cjfields]
181 1.6.900 April 14, 201
185 * This will probably be the last release to add significant features to
186 core modules; subsequent releases will be for bug fixes alone.
187 We are planning on a restructuring of core for summer 2011, potentially
188 as part of the Google Summer of Code. This may become BioPerl 2.0.
189 * Version bump represents 'just prior to v 1.7'. We may have point
190 releases to deal with bugs, with increments of 1.6.901, 1.6.902, etc.
191 This code essentially is what is on the github master branch.
195 * Core code updated for perl 5.12.x [cjfields, Charle Tilford]
197 - major overhaul of Bio::Tree code by Greg Jordan, fixes several bugs
198 - removal of Scalar::Util::weaken code, which was causing odd headaches
199 with premature GC, memory leaks with perl 5.10.0, etc [cjfields]
200 * Bio::DB::SeqFeature bug fixes for GBrowse2 compatibility [lds, scottcain,
202 * Bio::SeqIO::msout, Bio::SeqIO::mbsout - parsers for ms and mbs
205 - bug 2515 - new contribution [Ryan Golhar, jhannah]
207 - support for reading Maq, Sam and Bowtie files [maj]
208 - support for reading 454 GS Assembler (Newbler) ACE files [fangly]
209 - bug 2483: support for writing ACE files [Joshua Udall, fangly]
210 - bug 2599: support DBLINK annotation in GenBank files [cjfields]
211 - bug 2726: reading/writing granularity: whole scaffold or one contig
212 at a time [Joshua Udall, fangly]
214 - Added parsing of xrefs to OBO files, which are stored as secondary
215 dbxrefs of the cvterm [Naama Menda]
216 - General Interpro-related code refactors [dukeleto, rbuels, cjfields]
217 * PAML code updated to work with PAML 4.4d [DaveMessina]
221 * [3198] - sort tabular BLAST hits by score [DaveMessina]
222 * [3196] - fix invalid metadata produced by latest Module::Build [cjfields]
223 * [3190] - RemoteBlast GAPCOSTS regex fix [Ali Walsh, cjfields]
224 * [3185] - Bio::Tools::SeqStats->get_mol_wt now gives correct MW
226 * [3178] - fix tr/// issue in Bio::Range [Andrew Conley, cjfields]
227 * [3172] - Bio::DB::Fasta - catch possibly bad FASTA files [cjfields]
228 * [3164] - TreeFunctionsI syntax bug [gjuggler]
229 * [3163] - AssemblyIO speedup [fangly]
230 * [3160] - Bio::SearchIO::Writer::TextResultWriter output [Paul Cantalupo,
232 * [3159] - add SwissPfam support to bp_index.PLS [hyphaltip]
233 * [3158] - fix EMBL file mis-parsing [cjfields]
234 * [3157] - Bio::Restriction::Analysis 'sizes' method fixed [Marc Perry,
236 * [3153] - fix SeqIO::swiss TagTree issues [Charles Tilford, cjfields]
237 * [3148] - URL change for UniProt [cjfields]
238 * [3145] - AXT off-by-1 error [Aaron Goodman, cjfields]
239 * [3136] - HMMer3 parser fixes [kblin]
240 * [3126] - catch description [Toshihiko Akiba]
241 * [3122] - Catch instances where non-seekable filehandles were being
242 seek'd w/o checking for status [Stefan Kirov, Roy Chaudhuri]
243 * [3121] - Bio::OntologyIO cannot parse the full InterPro XML file
244 [dukeleto, rbuels, cjfields]
245 * [3120] - bp_seqfeature_gff3.pl round-trip fixes [genehack, David Breimann,
247 * [3116,3117] - perl 5.12.x warnings fixed [cjfields, Charles Tilford]
248 * [3110] - Better 'namespace' support for bp_seqfeature_load.PLS [dbolser,
250 * [3107] - BLAST alignment column_from_residue_number() [cjfields]
251 * [3104] - Bio::Species single node hierarchies [Charles Tilford, cjfields]
252 * [3092, 3090] - parsing of BLAST HSP stats [Razi Khaja, cjfields]
253 * [3089] - HSPTableWriter missing methods [Robson de Souza, cjfields]
254 * [3086] - EMBL misparsing long tags [kblin, cjfields]
255 * [3085] - CommandExts and array of files [maj, hyphaltip]
256 * [3077] - Bio::SimpleAlign slice() now correctly computes seq coordinates
257 for alignment slices [Ha X. Dang, cjfields]
258 * [3076] - XMFA alignment strand wrong [Ha X., cjfields]
259 * [3073] - fix parsing of GenBank files from RDP [cjfields]
260 * [3068] - FASTQ parse failure with trailing 0 [cjfields]
261 * [3064] - All-gap midline BLAST report issues [cjfields]
262 * [3063] - BLASt report RID [Razi Khaja, cjfields]
263 * [3058] - SearchIO::fasta parsing [DaveMessina, cjfields]
264 * [3053] - LOCUS line formatting [M. Wayne, cjfields]
265 * [3039] - correct Newick output root node branch length [gjuggler,
267 * [3038] - SELEX alignment error [Bernd, cjfields]
268 * [3033] - PrimarySeq ID setting [Bernd, maj]
269 * [3032] - Fgenesh errors [Wes Barris, hyphaltip]
270 * [3034] - AlignIO::clustal output [Bernd, DaveMessina]
271 * [3031] - Parse algorithm ref for BLAST [Razi Khaja, cjfields]
272 * [3028] - Bio::TreeIO::nexus and FigTree compat [Kevin Balbi, cjfields]
273 * [3025] - Bio::SeqIO::embl infinite loop [Adam Sjøgren, cjfields]
274 * [3040, 3023, 2974, 2921, 2753, 2636, 2482] - PAML parser fixed, works with
275 PAML 4.4d [DaveMessina]
276 * [3015, 3022] - Bio::Restriction withrefm regexp [Emmanuel Quevillon,
278 * [3020] - GFF3Loader alias attribute [Nathan Weeks, cjfields]
279 * [3018, 3019, 3021] - gmap_f9 parsing [Kiran Mukhyala, cjfields]
280 * [3017] - using threads with Bio::DB::GenBank [cjfields]
281 * [3012] - Bio::Root::HTTPget fixes [maj, cjfields]
282 * [3011] - namespace support for SF::Store::DBI::Pg [Adam Witney, cjfields]
283 * [3002] - Bio::DB::EUtilities NCBI policy updates [cjfields]
284 * [3001] - seq identifier '0' dropped with FASTA [Michael Kuhn, maj]
285 * [2984] - let LocatableSeq decide on length of phylip aln [Adam Witney,
287 * [2983] - fix score/percent ID mixup [Alexie Papanicolaou]
288 * [2977] - TreeIO issues [DaveMessina]
289 * [2959] - Bio::SeqUtils->revcom_with_features [Roy Chaudhuri, maj]
290 * [2944] - Bio::Tools::GFF score [cjfields]
291 * [2942] - correct MapTiling output [maj]
292 * [2939] - PDB residue insertion codes [John May, maj]
293 * [2930] - PrimarySeqI term symbol [Adam Sjøgren, maj]
294 * [2928] - GuessSeqFormat raw [maj]
295 * [2926] - Bio:Tools::TandemRepeatsFinder seq_id [takadonet, cjfields]
296 * [2922] - open() directive issue [cjfields]
297 * [2915] - GenBank parser infinite loop [Francisco Ossandon, cjfields]
298 * [2901] - DNAStatistics div by zero error [Janet Young, cjfields]
299 * [2899] - SeqFeature::Store host issues [lstein, dbolser]
300 * [2897] - Add a "mask_below_threshold" method to Seq::Quality [dbolser,
302 * [2881] - .scf files don't' roundtrip [Adam Sjøgren, cjfields]
303 * [2876] - CDD search with RemoteBlast [Malcolm Cook]
304 * [2863] - Root::IO::_initialize_io causes crash [rbuels, maj, DaveMessina]
305 * [2845] - Bio::Seq::Quality gives seq with no ID [Tristan Lefebure, cjfields]
306 * [2843] - FeatureIO BED to GFF fails w/ no phase [cassjm cjfields]
307 * [2773] - Bio::Tree::Node premature GC [Morgan Price, cjfields]
308 * [2764] - add ID Tracker helper for SwissProt [heikki, cjfields]
309 * [2758] - Bio::AssemblyIO ace problems [fangly]
310 * [2744] - Bio::LocatableSeq::end [Bernd, cjfields]
311 * [2726] - ace file IO [Josh, fangly]
312 * [2700] - Refactor Build.PL [cjfields]
313 * [2673] - addition of simple Root-based clone() method [cjfields]
314 * [2648] - Bio::Assembly::Scaffold->get_all_seq_ids [dbolser, fangly]
315 * [2599] - support for DBLINK annotation in GenBank files [cjfields]
316 * [2594] - Bio::Species memory leak [cjfields]
317 * [2515] - GenBank XML parser [jhannah]
318 * [2499] - Method "pi" in package Bio::PopGen::Statistics [hyphaltip]
319 * [2483] - Bio::Assembly::IO::ace write_assembly implemented [fangly]
320 * [2350] - ID consistency btwn Bio::SeqI, Bio::Align::AlignI [fangly,
322 * [1572] - no docs Bio::Location::Simple/Atomic::trunc [hyphaltip]
326 * Bio::Expression modules - these were originally designed to go with the
327 bioperl-microarray suite of tools, however they have never been completed
328 and so have been removed from the distribution. The original code has
329 been moved into the inactive bioperl-microarray suite. [cjfields]
333 * Repository moved from Subversion (SVN) to
334 http://github.com/bioperl/bioperl-live [cjfields]
335 * Bug database has moved to Redmine (https://redmine.open-bio.org)
336 * Bio::Micrarray - the tools developed for ReSeq chip analysis by Marian
337 Thieme have been moved to their own distribution (Bio-Microarray).
340 1.6.1 Sept. 29, 2009 (point release)
341 * No change from last alpha except VERSION and doc updates [cjfields]
343 1.6.0_6 Sept. 27, 2009 (sixth 1.6.1 alpha)
344 * Fix for silent OBDA bug related to FASTA validation [cjfields]
346 1.6.0_5 Sept. 27, 2009 (fifth 1.6.1 alpha)
347 * Possible fix for RT 49950 (Strawberry Perl installation) [cjfields]
348 * [RT 50048] - removed redundant VERSION, which was borking CPANPLUS
350 * BioPerl.pod -> BioPerl.pm (Perl Best Practices) [cjfields]
352 1.6.0_4 Sept. 25, 2009 (fourth 1.6.1 alpha)
353 * WinXP test fixes [cjfields, maj]
354 * BioPerl.pod added for descriptive information, fixes CPAN indexing
356 * Minor doc fixes [cjfields]
358 1.6.0_3 Sept. 22, 2009 (third 1.6.1 alpha)
359 * Fix tests failing due to merging issues [cjfields]
360 * More documentation updates for POD parsing [cjfields]
362 1.6.0_2 Sept. 22, 2009 (second 1.6.1 alpha)
364 - fix YAML meta data generation [cjfields]
366 1.6.0_1 Sept. 15, 2009 (first 1.6.1 alpha)
367 * Bio::Align::DNAStatistics
368 - fix divide by zero problem [jason]
370 - bug 2813 - fix faulty logic to detect end-of-stream [cjfields]
371 * Bio::AlignIO::stockholm
372 - bug 2796 - fix faulty logic to detect end-of-stream [cjfields]
373 * Bio::Assembly::Tools::ContigSpectrum
374 - function to score contig spectrum [fangly]
375 * Bio::DB::EUtilities
376 - small updates [cjfields]
378 - berkeleydb database now autoindexes wig files and locks correctly
381 - various small updates for stability; tracking changes to LANL
382 database interface [maj]
383 * Bio::DB::SeqFeature (lots of updates and changes)
384 - add Pg, SQLite, and faster BerkeleyDB implementations [lstein, scain]
385 - bug 2835 - patch [Dan Bolser]
386 - bug RT 44535 - patch FeatureFileLoader [Cathy Gresham]
388 - bug 2764 - idtracker() method [cjfields, courtesy Neil Saunders]
389 * Bio::Factory::FTLocationFactory
390 - mailing list bug fix [cjfields]
392 - performance work on column_from_residue_number [hartzell]
393 * Bio::Matrix::IO::phylip
394 - bug 2800 - patch to fix phylip parsing [Wei Zou]
396 - Google Summer of Code project from Chase Miller - parsers for Nexml
397 file format [maj, chmille4]
399 - Make Individual, Population, Marker objects AnnotatableI [maj]
400 - simplify LD code [jason]
402 - deal with empty intersection [jason]
404 - significant overhaul of Bio::Restriction system: complete support for
405 external and non-palindromic cutters. [maj]
407 - CPANPLUS support, no automatic installation [sendu]
409 - allow IO::String (regression fix) [cjfields]
410 - catch unintentional undef values [cjfields]
411 - throw if non-fh is passed to -fh [maj]
412 * Bio::Root::Root/RootI
413 - small debugging and core fixes [cjfields]
415 - bug RT 48813 - fix for Strawberry Perl bug [kmx]
416 * Bio::Root::Utilities
417 - bug 2737 - better warnings [cjfields]
419 - tiling completely refactored, HOWTO added [maj]
420 NOTE : Bio::Search::Hit::* classes do not use this code directly; we
421 will deprecate usage of the older tiling code in the next BioPerl
423 - small fixes [cjfields]
425 - Infernal 1.0 output now parsed [cjfields]
426 - new parser for gmap -f9 output [hartzell]
427 - bug 2852 - fix infinite loop in some output [cjfields]
428 - blastxml output now passes all TODO tests [cjfields]
429 - bug 2346, 2850 - psl and exonerate parsing fixes [rbuels, jhannah, bvecchi, YAPC hackathon]
430 - RT 44782 - GbrowseGFF writer now catches evalues [Allen Day]
431 - bug 2575 - add two columns of additional output to HSPTableWriter [cjfields]
432 * Bio::Seq::LargePrimarySeq
433 - delete tempdirs [cjfields]
434 - bug fixes [rbuels, jhannah, bvecchi, YAPC hackathon]
436 - extract regions based on quality threshold value [Dan Bolser, heikki]
437 - bug 2847 - resolve threshold issue (rbuels, jhannah, bvecchi)
438 * Bio::SeqFeature::Lite
439 - various Bio::DB::SeqFeature-related fixes [lstein]
440 * Bio::SeqFeature::Tools::TypeMapper
441 - additional terms for GenBank to SO map [scain]
442 * Bio::SeqIO::chadoxml
443 - bug 2785 - patch to get this working for bp_seqconvert [cjfields]
445 - support for CDS records [dave_messina, Sylvia]
447 - complete refactoring to handle all FASTQ variants, perform validation,
448 write output. API now conforms with other Bio* parsers and the rest of
449 Bio::SeqIO (e.g. write_seq() creates fastq output, not fasta output).
451 * Bio::SeqIO::genbank
452 - bug 2784 - fix DBSOURCE issue [Phillip Garland]
453 - bug RT 44536 - support for UniProt/UniProtKB tests [cjfields]
454 * Bio::SeqIO::largefasta
455 - parser returns a Bio::Seq::LargePrimarySeq [jhannah]
457 - add option for 'single' and 'multiple'
459 - bug 2881 - fix scf round-tripping [Adam Søgren]
461 - bug 2766, 2810 - copy over tags from features, doc fixes [David
464 - bug 2793 - patch for add_seq index issue [jhannah, maj]
465 - bug 2801 - throw if args are required [cjfields]
466 - bug 2805 - uniq_seq returns SimpleAlign and hash ref of sequence types
467 [Tristan Lefebure, maj]
468 - bug fixes from YAPC hackathon [rbuels, jhannah, bvecchi]
469 - fix POD and add get_SeqFeatures filter [maj]
470 * Bio::Tools::dpAlign
471 - add support for LocatableSeq [ymc]
472 - to be moved to a separate distribution [cjfields, rbuels]
473 * Bio::Tools::EUtilities
474 - fix for two bugs from mail list [Adam Whitney, cjfields]
475 - add generic ItemContainerI interface for containing same methods
478 - fix up code, add more warnings [cjfields]
479 - to be moved to a separate distribution [cjfields, rbuels]
480 * Bio::Tools::Primer3
481 - bug 2862 - fenceposting issue fixed [maj]
482 * Bio::Tools::Run::RemoteBlast
483 - tests for remote RPS-BLAST [mcook]
484 * Bio::Tools::SeqPattern
485 - bug 2844 - backtranslate method [rbuels, jhannah, bvecchi]
486 * Bio::Tools::tRNAscanSE
487 - use 'gene' and 'exon' for proper SO, ensure ID is unique [jason]
489 - bug 2456 - fix reroot_tree(), added create_node_on_branch() [maj]
490 * Bio::Tree::Statistics
491 - several methods for calculating Fitch-based score, internal trait
492 values, statratio(), sum of leaf distances [heikki]
494 - bug 2869 - add docs indicating edge case where nodes can be
495 prematurely garbage-collected [cjfields]
496 - add as_text() function to create Tree as a string in specified format
498 * Bio::Tree::TreeFunctionsI
499 - bug 2877 - fix bug where bootstrap assigned to the wrong node [Tristan
501 * Bio::TreeIO::newick
502 - fix small semicolon issue [cjfields]
504 - update to bp_seqfeature_load for SQLite [lstein]
505 - hivq.pl - commmand-line interface to Bio::DB::HIV [maj]
506 - fastam9_to_table - fix for MPI output [jason]
507 - gccalc - total stats [jason]
509 - POD cleanup re: FEEDBACK section [maj, cjfields]
510 - cleanup or fix dead links [cjfields]
511 - Use of no_* methods (indicating 'number of something') is deprecated
512 in favor of num_* [cjfields]
513 - lots of new tests for the above bugs and refactors [everyone!]
514 - new template for Komodo text editor [cjfields]
517 * Feature/Annotation rollback
518 - Problematic changes introduced prior to the 1.5 release have been
519 rolled back. These changes led to subtle bugs involving operator
520 overloading and interface methods.
521 - Behavior is very similar to that for BioPerl 1.4, with tag values
522 being stored generically as simple scalars. Results in a modest
525 - Split into a separate distribution on CPAN, primarily so development
526 isn't reliant on a complete BioPerl release.
527 - Bio::Graphics::Pictogram has been renamed to Bio::Draw::Pictogram but
528 is only available via Subversion (via bioperl-live main trunk)
530 - Common test bed for all BioPerl modules
532 - Common Module::Build-based subclass for all BioPerl modules
533 * Bio::DB::EUtilities
534 - Complete refactoring to split up parsing (Bio::Tools::EUtilities),
535 parameter handling (Bio::Tools::EUtilities::EUtilParameters),
536 and user agent request posting and retrieval
537 * Test implementation and reorganization
538 - Tests have been reorganized into groups based on classes or use
540 - Automated test coverage is now online:
541 http://www.bioperl.org/wiki/Test_Coverage
542 - After this release, untested modules will be moved into a
543 separate developer distribution until tests can be derived.
544 Also, new modules to be added are expected to have a test suite
545 and adequate test coverage.
547 1.5.2 Developer release
549 Full details of changes since 1.5.1 are available online at:
550 http://www.bioperl.org/wiki/Change_log
551 The following represents a brief overview of the most important changes.
554 - Overhaul. Brand new system fully allows markers to have multiple
555 positions on multiple maps, and to have relative positions. Should be
559 - This module and all the modules in the Taxonomy directory now
560 deprecated in favour of Bio::Taxon and Bio::Tree::Tree
565 * get_Taxonomy_Node() eventually to be deprecated, renamed get_taxon().
567 * New methods ancestor(), each_Descendent() and _handle_internal_id().
569 * Allows for different database modules to create Bio::Taxon objects
570 with the same internal id when the same taxon is requested from each.
573 * get_Children_Taxids() is deprecated, superceded by each_Descendent().
575 * No longer includes the fake root node 'root'; there are multiple roots
576 now (10239, 12884, 12908, 29384 and 131567). Consistent with entrez.pm
579 * get_node() has new option -full
581 * Caches data retrieved from website
584 - Now a Bio::Taxon. Carries out the species name -> specific name munging
585 that Bio::DB::Taxonomy modules and SeqIO modules used to do, for
586 backward compatability in species() method.
588 o Bio::Search and Bio::SearchIO
589 - Overhaul. The existing system has been sped up via some minor changes
590 (mostly gain-of-function to the API). Bio::PullParserI is introduced
591 as a potential eventual replacment for the existing system, though as
592 yet only a Hmmpfam parser exists written using it.
595 1.5.1 Developer release
597 o Major problem with how Annotations were written out with
598 Bio::Seq is fixed by reverting to old behavior for
599 Bio::Annotation objects.
604 * bug #1871; REFLOOP' parsing loop, I changed the pattern to
605 expect at l east 9 spaces at the beginning of a line to
606 indicate line wrapping.
608 * Treat multi-line SOURCE sections correctly, this defect broke
609 both common_name() and classification()
611 * parse swissprot fields in genpept file
613 * parse WGS genbank records
616 * Changed regexp for ID line. The capturing parentheses are
617 the same, the difference is an optional repeated-not-semi-
618 colon expression following the captured \S+. This means the
619 regexp works when the division looks like /PRO;/ or when the
620 division looks like /ANG ;/ - the latter is from EMBL
623 * fix ID line parsing: the molecule string can have spaces in
624 it. Like: "genomic DNA"
626 - swiss.pm: bugs #1727, #1734
629 * Added parser for entrezgene ASN1 (text format) files.
630 Uses Bio::ASN1::EntrezGene as a low level parser (get it from CPAN)
634 - maf.pm coordinate problem fixed
636 o Bio::Taxonomy and Bio::DB::Taxonomy
638 - Parse NCBI XML now so that nearly all the taxonomy up-and-down
639 can be done via Web without downloading all the sequence.
641 o Bio::Tools::Run::RemoteBlast supports more options and complies
642 to changes to the NCBI interface. It is reccomended that you
643 retrieve the data in XML instead of plain-text BLAST report to
644 insure proper parsing and retrieval of all information as NCBI
645 fully expects to change things in the future.
647 o Bio::Tree and Bio::TreeIO
649 - Fixes so that re-rooting a tree works properly
651 - Writing out nhx format from a newick/nexus file will properly output
652 bootstrap information. The use must move the internal node labels over
654 for my $node ( grep { ! $_->is_Leaf } $tree->get_nodes ) {
655 $node->bootstrap($node->id);
658 - Nexus parsing is much more flexible now, does not care about
661 - Cladogram drawing module in Bio::Tree::Draw
663 - Node height and depth now properly calculated
665 - fix tree pruning algorithm so that node with 1 child gets merged
667 o Graphics tweaks. Glyph::xyplot improved. Many other small-medium sized
668 bugs and improvements were added, see Gbrowse mailing list for most of
671 o Bio::DB::GFF partially supports GFF3. See information about
672 gff3_munge flag in scripts/Bio-DB-GFF/bulk_load_gff.pl.
674 o Better location parsing in Bio::Factory::FTLocationFactory -
675 this is part of the engine for parsing EMBL/GenBank feature table
676 locations. Nested join/order-by/complement are allowed now
678 o Bio::PrimarySeqI->translate now takes named parameters
680 o Bio::Tools::Phylo::PAML - parsing RST (ancestral sequence
681 reconstruction) is now supported. Parsing different models and
682 branch specific parametes are now supported.
684 o Bio::Factory::FTLocationFactory - parse hierarchical locations
687 o Bio::Matrix::DistanceMatrix returns arrayrefs instead of arrays
688 for getter/setter functions
692 - blast bug #1739; match scientific notation in score
693 and possible e+ values
695 - blast.pm reads more WU-BLAST parameters and parameters, match
696 a full database pathname,
698 - Handle NCBI WEB and newer BLAST formats specifically
699 (Query|Sbjct:) match in alignment blocks can now be (Query|Sbjct).
701 - psl off-by-one error fixed
703 - exonerate parsing much improved, CIGAR and VULGAR can be parsed
704 and HSPs can be constructed from them.
706 - HSPs query/hit now have a seqdesc field filled out (this was
707 always available via $hit->description and
708 $result->query_description
710 - hmmer.pm can parse -A0 hmmpfam files
712 - Writer::GbrowseGFF more customizeable.
714 o Bio::Tools::Hmmpfam
715 make e-value default score displayed in gff, rather than raw score
716 allow parse of multiple records
719 1.5 Developer release
721 o Bio::Align::DNAStatistics and Bio::Align::ProteinStatistics
722 provide Jukes-Cantor and Kimura pairwise distance methods,
725 o Bio::AlignIO support for "po" format of POA, and "maf";
726 Bio::AlignIO::largemultifasta is a new alternative to
727 Bio::AlignIO::fasta for temporary file-based manipulation of
728 particularly large multiple sequence alignments.
730 o Bio::Assembly::Singlet allows orphan, unassembled sequences to
731 be treated similarly as an assembled contig.
733 o Bio::CodonUsage provides new rare_codon() and probable_codons()
734 methods for identifying particular codons that encode a given
737 o Bio::Coordinate::Utils provides new from_align() method to build
738 a Bio::Coordinate pair directly from a
739 Bio::Align::AlignI-conforming object.
741 o Bio::DB::Biblio::eutils is a class for querying NCBI's Eutils.
742 Send a Pubmed, Pubmed Central, Entrez, or other query to NCBI's
743 web service using standard Pubmed query syntax, and retrieve
746 o Bio::DB::GFF has various sundry bug fixes.
748 o Bio::FeatureIO is a new SeqIO-style subsystem for
749 writing/reading genomic features to/from files. I/O classes
750 exist for BED, GTF (aka GFF v2.5), and GFF v3. Bio::FeatureIO
751 classes only read/write Bio::SeqFeature::Annotated objects.
752 Notably, the GFF v3 class requires features to be typed into the
755 o Bio::Graph namespace contains new modules for manipulation and
756 analysis of protein interaction graphs.
758 o Bio::Graphics has many bug fixes and shiny new glyphs.
760 o Bio::Index::Hmmer and Bio::Index::Qual provide multiple-file
761 indexing for HMMER reports and FASTA qual files, respectively.
763 o Bio::Map::Clone, Bio::Map::Contig, and Bio::Map::FPCMarker are
764 new objects that can be placed within a Bio::Map::MapI-compliant
765 genetic/physical map; Bio::Map::Physical provides a new physical
766 map type; Bio::MapIO::fpc provides finger-printed clone mapping
769 o Bio::Matrix::PSM provide new support for postion-specific
770 (scoring) matrices (e.g. profiles, or "possums").
772 o Bio::Ontology::Ontology and Bio::Ontology::Term objects can now
773 be instantiated without explicitly using Bio::OntologyIO. This
774 is possible through changes to Bio::Ontology::OntologyStore to
775 download ontology files from the web as necessary. Locations of
776 ontology files are hard-coded into
777 Bio::Ontology::DocumentRegistry.
779 o Bio::PopGen includes many new methods and data types for
780 population genetics analyses.
782 o New constructor to Bio::Range, unions(). Given a list of
783 ranges, returns another list of "flattened" ranges --
784 overlapping ranges are merged into a single range with the
785 mininum and maximum coordinates of the entire overlapping group.
787 o Bio::Root::IO now supports -url, in addition to -file and -fh.
788 The new -url argument allows one to specify the network address
789 of a file for input. -url currently only works for GET
790 requests, and thus is read-only.
792 o Bio::SearchIO::hmmer now returns individual Hit objects for each
793 domain alignment (thus containing only one HSP); previously
794 separate alignments would be merged into one hit if the domain
795 involved in the alignments was the same, but this only worked
796 when the repeated domain occured without interruption by any
797 other domain, leading to a confusing mixture of Hit and HSP
800 o Bio::Search::Result::ResultI-compliant report objects now
801 implement the "get_statistics" method to access
802 Bio::Search::StatisticsI objects that encapsulate any
803 statistical parameters associated with the search (e.g. Karlin's
804 lambda for BLAST/FASTA).
806 o Bio::Seq::LargeLocatableSeq combines the functionality already
807 found in Bio::Seq::LargeSeq and Bio::LocatableSeq.
809 o Bio::SeqFeature::Annotated is a replacement for
810 Bio::SeqFeature::Generic. It breaks compliance with the
811 Bio::SeqFeatureI interface because the author was sick of
812 dealing with untyped annotation tags. All
813 Bio::SeqFeature::Annotated annotations are Bio::AnnotationI
814 compliant, and accessible through Bio::Annotation::Collection.
816 o Bio::SeqFeature::Primer implements a Tm() method for primer
817 melting point predictions.
819 o Bio::SeqIO now supports AGAVE, BSML (via SAX), CHAOS-XML,
820 InterProScan-XML, TIGR-XML, and NCBI TinySeq formats.
822 o Bio::Taxonomy::Node now implements the methods necessary for
823 Bio::Species interoperability.
825 o Bio::Tools::CodonTable has new reverse_translate_all() and
826 make_iupac_string() methods.
828 o Bio::Tools::dpAlign now provides sequence profile alignments.
830 o Bio::Tools::GFF now parses GFF version 2.5 (a.k.a. GTF).
832 o Bio::Tools::Fgenesh, Bio::Tools::tRNAscanSE are new report
835 o Bio::Tools::SiRNA includes two new rulesets (Saigo and Tuschl)
836 for designing small inhibitory RNA.
838 o Bio::Tree::DistanceFactory provides NJ and UPGMA tree-building
839 methods based on a distance matrix.
841 o Bio::Tree::Statistics provides an assess_bootstrap() method to
842 calculate bootstrap support values on a guide tree topology,
843 based on provided bootstrap tree topologies.
845 o Bio::TreeIO now supports the Pagel (PAG) tree format.
851 o Improvements to Bio::AlignIO::nexus for parsing TreeBase nexus files
853 o Bio::Graphics will work with gd1 or gd2
856 - hmmer.pm Better hmmpfam parsing, fix bug for small number of alignment outputs
858 - blast.pm Parse multi-line query fields properly
859 - small speed improvements to blasttable.pm and others
861 o Bio::DB::Taxonomy has better support for hierarchy traversal so that
862 Bio::Taxonomy::Node can be as simple as Bio::Species object while still
863 supporting more complex queries
866 1.4. Stable major release
868 Since initial 1.2.0, 3000 separate changes have been made to make this release.
870 o installable scripts
872 o global module version from Bio::Root:Version
875 - major improvements; SVG support
878 - population genetics
879 - support several population genetics types of questions.
880 - Tests for statistical neutrality of mutations
881 (Fu and Li's D/F, Tajima's D) are in Bio::PopGen::Statistics.
882 Tests of population structure (Wright's F-statistic: Fst) is in
883 Bio::PopGen::PopStats. Calculating composite linkage
884 disequilibrium (LD) is available in Bio::PopGen::Statistics as
886 - Bio::PopGen::IO for reading in prettybase (SeattleSNPs)
887 and csv (comma delimited formatted) data.
889 - a directory for implementing population simulations has
890 been added Bio::PopGen::Simulation and 2 simulations - a
891 Coalescent and a simple single-locus multi-allele genetic drift
892 simulation have been provided. This replaces the code in
893 Bio::Tree::RandomTree which has been deprecated until proper
894 methods for generating random phylogenetic trees are
898 - new restrion analysis modules
900 o Bio::Tools::Analysis
901 - web based DNA and Protein analysis framework and several
905 - per residue annotable sequences
908 - Bio::Matrix::PSM - Position Scoring Matrix
909 - Bio::Matrix::IO has been added for generalized parsing of
910 matrix data. Matrix::IO::scoring and Matrix::IO::phylip are
911 initial implementations for parsing BLOSUM/PAM and Phylip
912 Distance matricies respectively. A generic matrix
913 implementation for general use was added in
914 Bio::Matrix::Generic.
921 o Bio::Tools::SiRNA, Bio::SeqFeature::SiRNA
922 - small inhibitory RNA
924 o Bio::SeqFeature::Tools
925 - seqFeature mapping tools
926 - Bio::SeqFeature::Tools::Unflattener.pm
927 -- deal with mapping GenBank feature collections into
928 Chado/GFF3 processable feature sets (with SO term mappings)
930 o Bio::Tools::dpAlign
931 - pure perl dynamic programming sequence alignment
934 o new Bio::SearchIO formats
935 - axt and psl: UCSC formats.
936 - blasttable: NCBI -m 8 or -m 9 format from blastall
938 o new Bio::SeqIO formats
939 - chado, tab, kegg, tigr, game
940 - important fixes for old modules
944 o improved Bio::Tools::Genewise
946 o Bio::SeqIO now can recongnize sequence formats automatically from
949 o new parsers in Bio::Tools:
950 Blat, Geneid, Lagan, Mdust, Promoterwise, PrositeScan,
952 o Bio::DB::Registry bugs fixed
953 - BerkeleyDB-indexed flat files can be used by the OBDA system
954 - Multiple seqdatabase.ini locations in OBDA_SEARCH_PATH are all
955 used by the OBDA system
958 - SimpleWebAnalysis, Trees, Feature Annotation, OBDA Access, Flat
961 o hundreds of new and improved files
965 o Bio::Tree::AlleleNode has been updated to be a container of
966 an Bio::PopGen::Individual object for use in the Coalescent simulations.
971 1.2.3 Stable release update
972 o Bug #1475 - Fix and add speedup to spliced_seq for remote location
974 o Bug #1477 - Sel --> Sec abbreviation fixed
975 o Fix bug #1487 where paring in-between locations when
976 end < start caused the FTLocationFactory logic to fail.
977 o Fix bug #1489 which was not dealing with keywords as an
978 arrayref properly (this is fixed on the main trunk because
979 keywords returns a string and the array is accessible via
981 o Bio::Tree::Tree memory leak (bug #1480) fixed
982 Added a new initialization option -nodelete which
983 won't try and cleanup the containing nodes if this
985 o Bug with parsing labeled nodes with Bio::TreeIO::newick fixed
986 this was only present on the branch for the 1.2.1 and 1.2.2 series
987 - Also merged main trunk changes to the branch which make
988 newick -> nhx round tripping more effective (storing branch length
989 and bootstrap values in same locate for NodeNHX and Node
990 implementations.) Fixes to TreeIO parsing for labeled internal
991 also required small changes to TreeIO::nhx. Improved
992 tests for this module as well.
994 - Fixed bugs in BLAST parsing which couldn't parse NCBI
995 gapped blast properly (was losing hit significance values due to
996 the extra unexpeted column).
997 - Parsing of blastcl3 (netblast from NCBI) now can handle case of
998 integer overflow (# of letters in nt seq dbs is > MAX_INT)
999 although doesn't try to correct it - will get the negative
1000 number for you. Added a test for this as well.
1001 - Fixed HMMER parsing bug which prevented parsing when a hmmpfam report
1002 has no top-level family classification scores but does have scores and
1003 alignments for individual domains.
1004 - Parsing FASTA reports where ungapped percent ID is < 10 and the
1005 regular expression to match the line was missing the possibility of
1006 an extra space. This is rare, which is why we probably did not
1008 - BLAST parsing picks up more of the statistics/parameter fields
1009 at the bottom of reports. Still not fully complete.
1010 - SearchIO::Writer::HTMLResultWriter and TextResultWriter
1011 were fixed to include many improvements and added flexiblity
1012 in outputting the files. Bug #1495 was also fixed in the process.
1014 - Update for GFF3 compatibility.
1015 - Added scripts for importing from UCSC and GenBank.
1016 - Added a 1.2003 version number.
1019 - Added a 1.2003 version number.
1020 o SeqIO::swiss Bug #1504 fixed with swiss writing which was not
1021 properly writing keywords out.
1022 o Bio::SeqIO::genbank
1023 - Fixed bug/enhancement #1513 where dates of
1024 the form D-MMM-YYYY were not parsed. Even though this is
1025 invalid format we can handle it - and also cleanup the date
1026 string so it is properly formatted.
1027 - Bug/enhancement #1517 fixed so that SEGMENT line can be parsed
1028 and written with Genbank format. Similarly bug #1515 is fixed to
1029 parse in the ORIGIN text.
1030 o Bio::SeqIO::fasta, a new method called preferred_id_type allows you
1031 to specify the ID type, one of (accession accession.version
1032 display primary). See Bio::SeqIO::preferred_id_type method
1033 documentation for more information.
1034 o Unigene parsing updated to handle file format changes by NCBI
1036 1.2.2 Stable release update
1038 o A series of bug fixes of the Bio::OntologyIO dagflat-related parsers:
1039 - auto-discover ontology name
1040 - bug in parsing relationships when certain characters are in the term
1041 - fixed hard-coded prefix for term identifiers
1042 - various smaller issues
1044 o Fixed bug in Bio::Annotation::OntologyTerm of not implementing all
1045 of Bio::Ontology::TermI
1047 o brought the OBDA Registry code up to latest specs
1051 - accession number retrieval fixed
1053 o Bio::SearchIO::blast - fix bug #1443 (missing last hits), parse megablast
1055 o Bio::SearchIO::Writer::(HTML|Text)ResultWriter fix bugs #1458,
1056 #1459 which now properly report alignment start/end info
1057 for translated BLAST/FASTA searches.
1059 o Bio::TreeIO::newick can parse labeled internal nodes
1061 o Bio::Tools::BPbl2seq can properly report strand info for HSPs
1062 for BLASTX if if you provide -report_type => 'BLASTX' when
1063 initializing a BPbl2seq object. Bioperl 1.3 will have better
1064 support for bl2seq in the SearchIO system.
1066 o Bio::Root::IO support a -noclose boolean flag which will not
1067 close a filehandle upon object cleanup - useful when sharing
1068 a filehandle among objects. Additionally code added s.t.
1069 STDOUT/STDIN/STDERR will never be closed by Root::IO cleanup.
1071 o Bio::Tools::Genemark bug #1435 fixed which was missing last prediction
1073 o Bio::SeqIO::genbank
1074 - bug #1456 fixed which generated extra sequence lines
1075 - write moltype correctly for genpept
1077 1.2.1 Stable release update
1079 o Inclusion of WrapperBase, a needed component for StandAloneBlast
1081 o Addition from main trunk of Ontology objects, principly to allow
1082 BioSQL releases against 1.2.1
1084 o Fixes and cleanup of Bio::Coordinate modules
1086 o A fix to Bio::Index::EMBL allowing retrieval of entries using
1087 the primary accession number
1089 o Other bug fixes, including bpindex GenBank fix
1091 o Bio::SeqIO::genbank bug #1389 fixed
1093 1.2 Stable major release
1095 o More functionality added to Bio::Perl, the newbie module
1097 o Bug fixes in Bio::TreeIO::newick fixes bug introduced in 1.0.2
1098 Support for New Hampshire Extended (NHX) format parsing.
1100 o Bio::Tools added support for parsing Genomewise, Pseudowise, Est2Genome,
1101 Tmhmm, SignalP, Seg, RepeatMasker, FootPrinter, and a lightweight
1104 o New ontology parsing Bio::Ontology
1106 o Bug fixes in Bio::SearchIO for HMMer parsing, support for
1107 multi-report (mlib) fasta reports, support for waba and exonerate.
1109 o Bio::ClusterIO for parsing Unigene clusters
1111 o Bio::Assembly added for representing phrap and ace assembly clusters.
1113 o Rudimentary support for writing Chado XML (see
1114 GMOD project: www.gmod.org for more information)
1116 o Bio::Coordinate for mapping between different coordinate systems such
1117 as protein -> cDNA -> Exon -> DNA and back. Useful for mapping
1118 features into different coordinate systems.
1120 o Bio::DB::GenBank/Bio::DB::GenPept now support Entrez queries
1121 with the get_Stream_by_query method and supports the latest
1122 NCBI eutils interface.
1124 o Bugs fixed in Bio::SeqFeature::Collection an in-memory fast
1125 object for extracting subsets of features : currently only
1126 supports extraction by location.
1128 1.1.1 Developer release
1130 o Deprecated modules are now listed in the DEPRECATED file
1132 o New HowTo documents located in doc/howto describing
1133 a domain of Bioperl.
1135 o Note that bugs are now stored at redmine.open-bio.org/projects/bioperl/
1136 and all old bugs are searchable through the bugzilla interface.
1138 o Several reported bugs in Bio::Tools::Sigcleave and Bio::SimpleAlign
1139 have been addressed.
1141 o Support for Genewise parsing in Bio::Tools::Genewise
1143 o Start of Ontology framework with Bio::Ontology
1145 o Speedup to the Bio::Root::Root object method _rearrange.
1146 A global _load_module method was implemented to simplify the
1147 dynamic loading of modules ala Bio::SeqIO::genbank. This
1148 method is now used by all the XXIO (AlignIO,TreeIO,SearchIO,SeqIO,
1151 o Several performance improvements to sequence parsing in Bio::SeqIO.
1152 Attempt to speedup by reducing object creation overhead.
1154 o Bio::DB::GenBank and Bio::DB::GenPept use the NCBI's approved
1155 method for sequence retrieval with their E-utils CGI scripts.
1156 More work to support Entrez queries to their fullest is planned
1159 o Numerous fixes to Bio::SearchIO and sequence parsing (swissprot)
1161 1.1 Developer release
1163 o Bio::Tools::Run has been broken off into a new pkg bioperl-run,
1164 this separation removes some of the complexity in our test suite
1165 and separates the core modules in bioperl from those that need
1166 external programs to run.
1168 o With latest ExtUtils::MakeMaker module installed SGI/IRIX should
1169 not run into trouble running the makefile
1171 o Bio::Location and Bio::SeqIO::FTHelper are fixed to properly
1172 read,create,and write locations for grouped/split locations
1173 (like mRNA features on genomic sequence).
1175 o Bio::Tools::Phlyo added for wrappers for parsing Molphy (protml)
1176 and PAML (codeml,aaml, etc) parsing.
1178 o Bio::Tree:: objects expanded to handle testing monophyly,
1179 paraphyly, least common ancestor, etc.
1181 o Bio::Coordinate for mapping locations from different coordinate spaces
1183 o Bio::SearchIO::waba added for parsing WABA, Bio::SearchIO::hmmer
1184 added for parsing hmmpfam and hmmsearch output.
1186 o Bio::SearchIO::Writer::TextResultWriter for outputting
1187 a pseudo-blast textfile format
1190 1.0.2 Bug fix release
1192 o Note: The modules Bio::DB::GenBank and Bio::DB::GenPept provided
1193 in this release will not work after December 2002 when NCBI
1194 shuts off the old Entrez cgi scripts. We have already fixed
1195 on our main development branch and the functionality will be
1196 available in the next stable bioperl release (1.2) slated for
1199 o Numerous parsing bugs in Bio::SearchIO::fasta found through
1200 testset by Robin Emig. These were fixed as was the get_aln
1201 method in Bio::Search::HSP::GenericHSP to handle the extra
1202 context sequence that is provided with a FastA alignment.
1204 o Migrating differences between Bio::Search::XX::BlastXX to
1205 Bio::Search::XX::GenericXX objects. This included mechanism
1206 to retrieve whole list of HSPs from Hits and whole list of Hits from
1207 Results in addition to the current next_XX iterator methods that
1208 are available. Added seq_inds() method to GenericHSP which identifies
1209 indexes in the query or hit sequences where conserved,identical,gaps,
1210 or mismatch residues are located (adapted from Steve Chervitz's
1211 implementation in BlastHSP).
1213 o Bio::DB::GFF bugs fixed and are necessary for latest GBrowse release.
1214 Bio::DB::GFF::RelSegment is now Bio::SeqI compliant.
1216 o Bio::Graphics glyph set improved and extended for GBrowse release
1218 o Bio::Tree::Tree get_nodes implementation improvement thanks
1219 to Howard Ross notice performance problem when writing out
1222 o Bio::Location::Fuzzy::new named parameter -loc_type became
1223 -location_type, Bio::Location::Simple::new named parameter
1224 -seqid becamse -seq_id.
1226 o Fixed major Bio::AlignIO::emboss parsing bug on needle output,
1227 was mis-detecting that gaps should be placed at the beginning of
1228 the alignment when the best alignment starts internally in the
1231 1.0.1 Bug fix release
1233 o Minor bug fixes to Bio::DB:GFF. Glyph sets improved.
1235 o Parser fixes in SearchIO blast, fasta for more complete WU BLAST
1236 and mixed (3.3 - 3.4) versions of FASTA.
1238 o Small API change to add methods for completeness across
1239 implementations of Bio::Search objects. These new methods
1240 in the interface are implemented by the GenericXX object as well
1241 as the BlastXX objects.
1242 * Bio::Search::Result::ResultI
1243 - hits() method returns list of all Hits (next_hit is an
1246 * Bio::Search::Hit::HitI
1247 - hsps() method returns list of all HSPs (next_hsp is an
1250 o The Bio::SearchIO::Writer classes have been fixed to handle results
1251 created from either psiblast (Search::BlastXX objects) or
1252 blast|fasta|blastxml objects (Search::GenericXX objects). More work
1253 has to be done here to make it work properly and will nee major
1256 o Bugs in Bio::Tools::HMMER fixed, including
1257 * #1178 - Root::IO destructor wasn't being called
1258 * #1034 - filter_on_cutoff now behaves properly
1260 o Bio::SeqFeature::Computation initialization args fixed and
1263 o Tests are somewhat cleaner, flat.t now properly cleans up after itsself,
1265 o Updated FAQ with more example based answers to typical questions
1267 o Bug #1202 was fixed which would improperly join together qual values
1268 parsed by Bio::SeqIO::qual when a trailing space was not present before
1271 1.0.0 Major Stable Release
1273 This represents a major release of bioperl with significant
1274 improvements over the 0.7.x series of releases.
1276 o Bio::Tools::Blast is officially deprecated. Please see
1277 Bio::SearchIO for BLAST and FastA parsing.
1279 o The methods trunc() and subseq() in Bio::PrimarySeqI now accepts
1280 Bio::LocationI objects as well as start/end.
1282 o Bio::Biblio contains modules for Bibliographic data.
1283 Bio::DB::Biblio contains the query modules. Additionally one can
1284 parse medlinexml from the ebi bibliographic query service (BQS)
1285 system and Pubmed xml from NCBI. See Martin Senger's
1286 documentation in Bio::Biblio for more information.
1288 o Bio::DB::Registry is a sequence database registry part of
1289 Open Bioinformatics Database Access. See
1290 http://obda.open-bio.org for more information.
1292 o File-based and In-Memory Sequence caching is provided by
1293 Bio::DB::InMemoryCache and Bio::DB::FileCache which acts like a
1296 o Bio::Graphics for rendering sequences as PNG,JPG, or GIFs has
1297 been added by Lincoln Stein.
1299 o XEMBL SOAP service access in provided in Bio::DB::XEMBL.
1301 o A FAQ has been started and is included in the release to provide
1302 a starting point for frequent questions and issues.
1304 0.9.3 Developer's release
1306 o Event based parsing system improved (SearchIO). With parsers for
1307 XML Blast (blastxml), Text Blast (blast), and FASTA results (fasta).
1308 Additionally a lazy parsing system for text and html blast reports was
1309 added and is called psiblast (name subject to change in future releases).
1311 o Bio::Search objects improved and standardized with associated Interfaces
1312 written. The concept of a search "Hit" was standardized to be called
1313 "hit" consistently and the use of "subject" was deprecated in all active
1316 o Bio::Structure added (since 0.9.1) for Protein structure objects
1317 and PDB parser to retrieve and write these structures from data files.
1319 o Several important Bio::DB::GFF bug fixes for handling features that
1320 are mapped to multiple reference points. Updated mysql adaptor
1321 so as to be able to store large (>100 megabase) chunks of DNA into
1322 Bio::DB::GFF databases.
1324 0.9.2 Developer's release
1326 o Bio::Search and Bio::SearchIO system introduced for event based
1327 parsing of Blast,Fasta reports Bio::SearchIO supports ncbi BLAST
1328 in text and XML and FASTA reports in standard output format.
1330 o Bio::Tree and Bio::TreeIO for phylogenetic trees. A Random tree
1331 generator is included in Bio::TreeIO::RandomTrees and a
1332 statistics module for evaluating.
1334 o Bio::DB::GFF, Lincoln Stein's GFF database suitable as a DB
1335 server for DAS servers.
1337 o Bio::Tools::BPlite is provides more robust parsing of BLAST
1338 files. The entire BPlite system migrated to using Bio::Root::IO
1339 for the data stream.
1341 o Bio::Tools::Alignment for Consed and sequence Trimming
1344 o Bio::Structure for Protein structure information and parsing
1346 o Bio::DB::GenBank/Bio::DB::GenPept updated to new NCBI Entrez
1347 cgi-bin entry point which should be more reliable.
1349 o Bio::Map and Bio::MapIO for biological map navigation and a
1350 framework afor parsing them in. Only preliminary work here.
1352 o Interface for executing EMBOSS programs locally in Bio::Factory::EMBOSS
1353 Future work will integrate Pise and allow submission of analysis on
1356 o Bio::AnnotationCollectionI and Bio::Annotation::Collection
1357 introduced as new objects for handling Sequence Annotation
1358 information (dblinks, references, etc) and is more robust that
1361 o Bio::Tools::FASTAParser introduced.
1363 o Scripts from the bioperl script submission project and new
1364 scripts from bioperl authors are included in "scripts" directory.
1366 o Factory objects and interfaces are being introduced and are more
1369 o Bio::Root::Root introduced as the base object while
1370 Bio::Root::RootI is now simply an interface.
1372 o Bio::DB::RefSeq provides database access to copy of the NCBI
1373 RefSeq database using the EBI dbfetch script.
1375 0.9.0 Developer's release
1377 o perl version at least 5.005 is now required instead of perl 5.004
1379 o Bio::Tools::Run::RemoteBlast is available for running remote
1382 o Bio::Tools::BPbl2seq was fixed to handle multiple HSPs.
1384 o Bio::SeqFeature::GeneStructure migrated to Bio::SeqFeature::Gene.
1385 Also added are related modules UTR3, UTR5, Exon, Intron,
1386 Promotor, PolyA and Transcript.
1388 o Speedup of translate method in PrimarySeq
1390 o Bio::SimpleAlign has new methods: location_from_column(), slice(),
1391 select(), dot(), get_seq_by_pos(), column_from_residue_number()
1393 o Various fixes to Variation toolkit
1395 o Bio::DB::EMBL provides database access to EMBL sequence data.
1396 Bio::DB::Universal provides a central way to point to indexes
1397 and dbs in a single interface.
1399 o Bio::DB::GFF - a database suitable for running DAS servers locally.
1401 o Bio::Factory::EMBOSS is still in design phase as is
1402 Bio::Factory::ApplicationFactoryI
1404 o Dia models for bioperl design are provided in the models/ directory
1406 0.7.2 Bug fix release
1408 o documentation fixes in many modules - SYNOPSIS code verified
1409 to be runnable in many (but not all modules)
1411 o corrected MANIFEST file from 0.7.1 release
1413 o Bug fix in Bio::SeqIO::FTHelper to properly handle
1416 o Bio::SeqIO::genbank
1417 * Correct parsing and writing of genbank format with protein data
1418 * moltype and molecule separation
1420 o Bio::SeqIO::largefasta fix to avoid inifinite loops
1422 o Bio::SimpleAlign fixed to correctly handle consensus
1423 sequence calculation
1425 o Bio::Tools::HMMER supports hmmer 2.2g
1427 o Bio::Tools::BPlite to support report type specific parsing. Most
1428 major changes are not on the 0.7 branch.
1430 o Bio::Tools::Run::StandAloneBlast exists_blast() fixed and works
1433 o Bio::Variation::AAChange/RNAChange corrected labels and mutated alleles
1434 in several types of mutations:
1435 1.) AA level: deletion, complex
1436 2.) AA level: complex, inframe
1437 3.) RNA level: silent
1439 o BPbl2seq parsing of empty reports will not die, but will return
1440 a valid, empty, Bio::SeqFeature::SimilarityFeature for
1441 $report->query() and $report->subject() methods. So an easy
1442 way to test if report was empty is to see if
1443 $report->query->seqname is undefined.
1445 0.7.1 Bug fix release
1447 o Better parsing of genbank/EMBL files especially fixing bugs
1448 related to Feature table parsing and locations on remote
1449 sequences. Additionally, species name parsing was better.
1451 o Bio::SeqIO::genbank can parse now NCBI produced genbank database
1452 which include a number of header lines.
1454 o More strict genbank and EMBL format writing (corrected number of
1455 spaces where appropriate).
1457 o Bio::Tools::BPlite can better parse BLASTX reports - see BUGS
1458 for related BPlite BUGS that are unresolved in this release.
1460 o Bio::DB::GenBank, Bio::DB::GenPept have less problems
1461 downloading sequences from NCBI via HTTP. Bio::DB::SwissProt can
1462 use expasy mirrors or EBI dbfetch cgi-script.
1464 o A moderate number of documentation improvements were made as
1465 well to provide a better code synopsis in each module.
1468 0.7 Large number of changes, including refactoring of the
1469 Object system, new parsers, new functionality and
1470 all round better system. Highlights are:
1473 o Refactored root of inheritance: moved to a lightweight Bio::Root::RootI;
1474 Bio::Root::IO for I/O and file/handle capabilities.
1476 o Imported BPlite modules from Ian Korf for BLAST
1477 parsing. This is considered the supported BLAST parser;
1478 Bio::Tools::Blast.pm will eventually phase out due to lack of support.
1480 o Improved Sequence Feature model. Added complete location
1481 modelling (with fuzzy and compound locations). See
1482 Bio::LocationI and the modules under Bio/Location. Added
1483 support in Genbank/EMBL format parsing to completely parse
1484 feature tables for complex locations.
1486 o Moved special support for databanks etc to specialized modules under
1487 Bio/Seq/. One of these supports very large sequences through
1488 a temporary file as a backend.
1490 o Explicit Gene, Transcript and Exon SeqFeature objects, supporting
1491 CDS retrieval and exon shuffling.
1493 o More parsers: Sim4, Genscan, MZEF, ESTScan, BPbl2seq, GFF
1495 o Refactored Bio/DB/GenBank+GenPept. There is now also DB/SwissProt and
1496 DB/GDB (the latter has platform-specific limitations).
1498 o New analysis parser framework for HT sequence annotation (see
1499 Bio::SeqAnalysisParserI and Bio::Factory::SeqAnalysisParserFactory)
1501 o New Alignment IO framework
1503 o New Index modules (Swissprot)
1505 o New modules for running Blast within perl
1506 (Bio::Tools::Run::StandAloneBlast). Added modules for running
1507 Multiple Sequence Alignment tools ClustalW and TCoffee
1508 (Bio::Tools::Run::Alignment).
1510 o New Cookbook-style tutorial (see bptutorial.pl). Improved
1511 documentation across the package.
1513 o Much improved cross platform support. Many known incompatibilities
1514 have been fixed; however, NT and Mac do not work across the entire
1515 setup (see PLATFORMS).
1517 o Many bug fixes, code restructuring, etc. Overall stability and
1518 maintainability benefit a lot.
1520 o A total of 957 automatic tests
1525 There are very few functionality changes but a large
1526 number of software improvements/bug fixes across the package.
1528 o The EMBL/GenBank parsing are improved.
1530 o The Swissprot reading is improved. Swissprot writing
1531 is disabled as it doesn't work at all. This needs to
1532 wait for 0.7 release
1534 o BLAST reports with no hits are correctly parsed.
1536 o Several other bugs of the BLAST parser (regular expressions, ...)
1539 o Old syntax calls have been replaced with more modern syntax
1541 o Modules that did not work at all, in particular the Sim4
1542 set have been removed
1544 o Bio::SeqFeature::Generic and Bio::SeqFeature::FeaturePair
1545 have improved compliance with interface specs and documentation
1547 o Mailing list documentation updated throughout the distribution
1549 o Most minor bug fixes have happened.
1551 o The scripts in /examples now work and have the modern syntax
1552 rather than the deprecated syntax
1555 0.6.1 Sun April 2 2000
1557 o Sequences can have Sequence Features attached to them
1558 - The sequence features can be read from or written to
1559 EMBL and GenBank style flat files
1561 o Objects for Annotation, including References (but not
1562 full medline abstracts), Database links and Comments are
1565 o A Species object to represent nodes on a taxonomy tree
1568 o The ability to parse HMMER and Sim4 output has been added
1570 o The Blast parsing has been improved, with better PSI-BLAST
1571 support and better overall behaviour.
1573 o Flat file indexed databases provide both random access
1574 and sequential access to their component sequences.
1576 o A CodonTable object has been written with all known
1577 CodonTables accessible.
1579 o A number of new lightweight analysis tools have been
1580 added, such as molecular weight determination.
1582 The 0.6 release also has improved software engineering
1584 o The sequence objects have been rewritten, providing more
1585 maintainable and easier to implement objects. These
1586 objects are backwardly compatible with the 0.05.1 objects
1588 o Many objects are defined in terms of interfaces and then
1589 a Perl implementation has been provided. The interfaces
1590 are found in the 'I' files (module names ending in 'I').
1592 This means that it is possible to wrap C/CORBA/SQL access
1593 as true "bioperl" objects, compatible with the rest of
1596 o The SeqIO system has been overhauled to provide better
1597 processing and perl-like automatic interpretation of <>
1600 o Many more tests have been added (a total of 172 automatic
1601 tests are now run before release).
1605 0.05.1 Tue Jun 29 05:30:44 1999
1606 - Central distribution now requires Perl 5.004. This was
1607 done to get around 5.003-based problems in Bio/Index/*
1609 - Various bug fixes in the Bio::Tools::Blast modules
1610 including better exception handling and PSI-Blast
1611 support. See Bio/Tools/Blast/CHANGES for more.
1612 - Fixed the Parse mechanism in Seq.pm to use readseq.
1613 Follow the instructions in README for how to install
1614 it (basically, you have to edit Parse.pm).
1615 - Improved documentation of Seq.pm, indicating where
1616 objects are returned and where strings are returned.
1617 - Fixed uninitialized warnings in Bio::Root::Object.pm
1618 and Bio::Tools::SeqPattern.pm.
1619 - Bug fixes for PR#s: 30,31,33-35,41,42,44,45,47-50,52.
1621 0.05 Sun Apr 25 01:14:11 1999
1622 - Bio::Tools::Blast modules have less memory problems
1623 and faster parsing. Webblast uses LWP and supports
1624 more functionality. See Bio/Tools/Blast/CHANGES for more.
1625 - The Bio::SeqIO system has been started, moving the
1626 sequence reformatting code out of the sequence object
1627 - The Bio::Index:: system has been started, providing
1628 generic index capabilities and specifically works for
1629 Fasta formatted databases and EMBL .dat formatted
1631 - The Bio::DB:: system started, providing access to
1632 databases, both via flat file + index (see above) and
1634 - The scripts/ directory, where industrial strength scripts
1635 are put has been started.
1636 - Many changes - a better distribution all round.
1638 0.04.4 Wed Feb 17 02:20:13 1999
1639 - Bug fixes in the Bio::Tools::Blast modules and postclient.pl
1640 (see Bio::Tools::Blast::CHANGES).
1641 - Fixed a bug in Bio::Tools::Fasta::num_seqs().
1642 - Beefed up the t/Fasta.t test script.
1643 - Small fix in Bio::Seq::type() (now always returns a string).
1644 - Changed Bio::Root::Utilities::get_newline_char() to
1645 get_newline() since it could return more than one char.
1646 - Added $NEWLINE and $TIMEOUT_SECS to Bio::Root::Global.
1647 - Changed default timeout to 20 seconds (was 3).
1648 - Moved lengthy modification notes to the bottom of some files.
1649 - Fixed SimpleAlign write_fasta bug.
1650 - Beefed up SimpleAlign.t test
1652 0.04.3 Thu Feb 4 07:48:53 1999
1653 - Bio::Root::Object.pm and Global.pm now detect when
1654 script is run as a CGI and suppress output that is only
1655 appropriate when running interactively.
1656 - Bio::Root::Err::_set_context() adds name of script ($0).
1657 - Added comments in Bio::Tools::WWW.pm and Bio::Root::Utilities.pm
1658 regarding the use of the static objects via the qw(:obj) tag.
1659 - Fixed the ambiguous reverse calls in Seq.pm and UnivAln.pm to
1660 CORE::reverse, avoiding Perl warnings.
1661 - Bug fixes in Bio::Tools::Blast modules (version 0.074) and
1662 example scripts (see Bio::Tools::Blast::CHANGES).
1663 - examples/seq/seqtools.pl no longer always warns about using
1664 -prot or -nucl command-line arguments; only when using the
1666 - Methods added to Bio::Root::Utilities: create_filehandle(),
1667 get_newline_char(), and taste_file() to generalize filehandle
1668 creation and autodetect newline characters in files/streams
1669 (see bug report #19).
1670 - Bio::Root::IOManager::read() now handles timeouts and uses
1671 Utilities::create_filehandle().
1672 - Bio::Tools::Fasta.pm uses Utilities::get_newline_char() instead
1673 of hardwiring in "\n".
1674 - Bug fixes in the Bio::SimpleAlign and Bio::Tools::pSW
1676 0.04.2 Wed Dec 30 02:27:36 1998
1677 - Bug fixes in Bio::Tools::Blast modules, version 0.073
1678 (see Bio::Tools::Blast::CHANGES).
1679 - Changed reverse calls in Bio/Seq.pm and Bio/UnivAln.pm
1680 to CORE::reverse (prevents ambiguous warnings with 5.005).
1681 - Appending '.tmp.bioperl' to temporary files created by
1682 Bio::Root::Utilities::compress() or uncompress() to
1683 make it easy to identify & cleanup these files as needed.
1684 - Developers: Created CVS branch release-0-04-bug from
1685 release-0-04-1. Before making bug fixes to the 0.04.1 release,
1686 be sure to cvs checkout this branch into a clean area.
1688 0.04.1 Wed Dec 16 05:39:15 1998
1689 - Bug fixes in Bio::Tools::Blast modules, version 0.072
1690 (see Bio::Tools::Blast::CHANGES).
1691 - Compile/SW/Makefile.PL now removes *.o and *.a files
1694 0.04 Tue Dec 8 07:49:19 1998
1695 - Lots of new modules added including:
1696 * Ewan Birney's Bio::SimpleAlign.pm, Bio::Tools::AlignFactory.pm,
1697 and Bio/Compile directory containing XS-linked C code for
1698 creating Smith-Waterman sequence alignments from within Perl.
1699 * Steve Chervitz's Blast distribution has been incorporated.
1700 * Georg Fuellen's Bio::UnivAln.pm for multiple alignment objects.
1701 - Bio/examples directory for demo scripts for all included modules.
1702 - Bio/t directory containing test suit for all included modules.
1703 - For changes specific to the Blast-related modules prior to
1704 incorporation in this central distribution, see the CHANGES
1705 file in the Bio/Tools/Blast directory.
1707 0.01 Tue Sep 8 14:23:22 1998
1708 - original version from central CVS tree; created by h2xs 1.18