2 (in-package :data-analysis-ontology
)
4 (session :conference
"ENAR" :session
"longitudinal data" :year
2009
6 (talk :name
"Jianwen Cai"
7 :title
"Joint Modeling of Longituindal Cat data and Surv data"
8 :topic
"joint survival longitudinal"
10 (example "liver transplant"
11 :goal
" baseline-chars disease-hist impact QOL and risk of death postliver transpliatatn"
13 (data :time
4m
1y
2y
3y
4y
5y
14 :measure QOL
(binary QOL
) (time death
)))
17 (selection "Tsiatis, T+ Wulfsohn, etc"
18 estimate
(conditional (survival-time T
)
19 (longitudinal data X
)))
20 (pattern mixture models
)
21 (simultaneous model
"Zheng Cai 2005"
22 (assume: (longitudinal-outcomes 'normal
)))
26 (model (GLMM longitudinal outcome
, random on subject
)
27 (PH T conditionl on random effects above and obsd history before t
))
31 (Zi Di Wi
(t) WTi
(t)))
33 (inference (parameters RE FE baseline CumHaz
)
34 (MLE 'complete-likelihood
'marginal on RE
)
36 (compute-with EM
'TLouis-est-var
))
38 (behavior (asympt RE FE CumHaz
:consistent
(product-norm (theta euclidean-distance
)
40 (finite-sample :assume
(list (longitudinal '(regression 'logistic
))
41 (event-time 'PH-model
))
42 :results
(fine under friendly conditions
)) ; FUFC
45 (example "Liver Transplant"
50 (summary :weird normal distr assumptions for REs ?
)))
52 (talk :name
"Mike Kenward"
53 :title
"Dropout in Long clin trial w/ binary outcome"
54 :topic
"clin trial; longitudinal ; binary response ; dropout/withdrawal"
55 :goal
"compare at endtime, endpoints"
57 (prior-art "contin outomces with MAR, MVN framework")
58 (issue "no natural generalization for MV binary resp")
59 (issue (contrast 'population-average
'subject-specific
)) ; marginal conditional
61 (with-missing-data (assert 'likelihood works
) (assert 'estimating-equation issues
))
64 (list ( Fitzmaurice
'cluster-weighted-gee
)
65 ( Robins
/Rotnitsky
'obn-weighted-gee
)
66 ( Paik
'MI-GEE
:multiple-imputation followed by
'complete-data-analysis
67 (meng 'imputation model conditions
))
68 ( Augmented Inverse Prob Wgt Est
:approach
" add-term with zero-expectation to incr eff,
69 see also scharfstein" :name AIPW
)
70 ( doubly robust multiple imputation
, but restricted
71 to single var dropout
, but
72 extended
/made practical by Bang and Robins
,
73 :limit
(assert monotone
) (var-est by bootstrap
) (models for
74 awkward expectations
) )
78 :name
"doubly robust MI"
79 :prop
"asympt equiv bang/robins"
80 :alg
(steps MI over seq of regressions
, Rubin
's MI var est possible
82 :theory
( (obs-weight-gee Aug-obs-weight-gee d
) asympt equiv for disc data
)
87 (MI-GEE more eff than obs-wgt-GEE
, up to N
=5000)
88 (aux term incr eff
/rob
)
89 (DRMI (sllight less eff than MI-GEE with Y corr spec
)
91 (practical implem use
(simple / clear
))))) )
93 (talk :name
"Xihong Lin"
94 :title
"variable selection using dantig selector"
98 (prior-art "Candes and Tao 2007" Dantzig Selector
99 (resemebles 'estimating-equation based var-select procedure
))
101 (proposal "extend to corr data")
102 (goal "select coefs which are non-zero")
104 (prior-art :penalized-likelihood
)
105 (prior-art :regularization
)
107 (control correlation-of-residuals
, not size of residuals
!)
109 (subject-to (min (norm 1 beta
))
110 (norm inf
(m* Xt
(Y - Xb
))))
112 (note (there-exists (class matrices
) st danztig-selector
113 inconsistent for model selection
))
115 (solution :weight selector through penalization to remove
121 (session "missing data"
123 (talk :name
"Geert M"
124 :title
"MNAR equiv to so MAR"
126 (example toe nail data
, longitudinal measure of serer toenail inferctions
)
127 (example slovenian public opiion survey on independence
128 3 q
's
: seccession-ind attend indep-grp ?
)
130 (frameworks (list selection
133 :missing-models MCAR-
>MAR-
>MNAR
)
135 (assumption "not dependence on future")
136 (approach "put past responses into future not, AR/markov style")
137 (everything MNAR model has MAR counterpart
)
139 (explicit guide to construction
)
141 (example :toe-nail infection severity within as a
142 past
/current marker to be managed when missing
) )
144 (talk :name
"mike daniels"
148 (endpoints dose-efficacy QOL
)
149 (rationale clinical-depression assoc with dose
)
154 (non-ignoreable missingness in longitudinal trials
)
156 (motivation :priors on missingness structure
,
157 MAR as a strong point-mass prior
)
160 (list (assert-hypothesis non-future-dependence
'data
)
161 (assert-hypothesis selection-model-rpresenttion
'model
)))
163 (model :observed-data
'transistion-model-parameterization
167 (issue :priors
"spec ORs, but ORs diff to spec, so push to RR")
172 (talk :name
"joe hogan"
173 :title
"formulating priors for calibrating priors with incomplete data"